MTX(G1) =
Relationship between clinical and patient reported outcomes in a phase 3 trial of tofacitinib or MTX in MTX naïve patients with rheumatoid arthritis
... Objective: To compare the relationship between clinical measures and patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA) treated with tofacitinib or methotrexate (MTX). Methods: In a phase ...
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Non-persistence and non-adherence to MTX therapy in patients with rheumatoid arthritis: a retrospective cohort study based on German RA patients
... 934 MTX prescriptions and the associated, physician-based PDDs of 160 RA patients (inclusion criteria: age above 18 years, confirmed RA diagnosis and current/previous treatment with MTX for at least 24 ...
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NEURO PROTECTIVE EFFECTS OF WHEAT GERM OIL ON THE BRAIN INFLAMMATION INDUCED BY METHOTREXATE IN MICE
... The aim of this study is to evaluate the neurotoxicity of methotrexate (MTX) in mice, as well as the neuroprotective effects of wheat germ oil (WGO). One group of mice received corn oil orally for 10 days and a ...
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Flaviviruses Are Sensitive to Inhibition of Thymidine Synthesis Pathways
... of MTX and FUDR on infected cells may have been counteracted by a reduced immune response to ...Although MTX is widely used in humans, we observed significant toxicity at high concen- trations in the form ...
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Methotrexate diethyl ester-loaded lipid-core nanocapsules in aqueous solution increased antineoplastic effects in resistant breast cancer cell line
... an MTX derivative (MTX diethyl ester [MTX(OEt) 2 ]) and MTX(OEt) 2 -loaded lipid-core nanocapsules in two MTX-resistant breast adenocarcinoma cell lines, MCF-7 and ...cells, ...
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Blood purification therapies in methotrexate-induced acute kidney injury: four case reports
... and MTX concentration were different in each case; therefore, a simple comparison was ...of MTX decreased after HD but HDF was subsequently ...of MTX; however, it was unclear whether HDF was more ...
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EFFECT OF HIGH DOSE METHOTREXATE AND DELAYED ELIMINATION ON MYELOTOXICITY PROGRESSION IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
... .This effect onblood counts especially RBCs and TLC is attributed to higher concentration of MTXPG in patients whose blast count decreased within 24 h . Blast cells are the origin of platelets, red blood cells, ...
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Therapeutic effect of quercetin in collagen-induced arthritis
... Advances to develop new treatments for RA have relied on animal models. The collagen-induced arthritis (CIA), model of RA, closely replicates the pathogenesis of the disease. Currently, therapeutic products for RA ...
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Long term in vitro 3D hydrogel co culture model of inflammatory bowel disease
... it was not possible to extract RNA/protein and thus quantifying gene/protein expression was not possible. Consequently qualitative changes relating to the presence or absence of immunohistochemical markers are reported. ...
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Bioreducible cross linked core polymer micelles enhance in vitro activity of methotrexate in breast cancer cells
... of MTX dissolved in DMSO-medium as another positive ...of MTX was prepared by first dissolving MTX in 200 µL DMSO, and volume was made up to 10 mL with ...
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Chloroplastic Protein Import Characteristics of Dihydrofolate Reductase (DHFR) Fused Recombinant Precursor Protein in the Presence of Methotrexate
... thermolysin. After E. coli overexpressed TP-HA- r1-DHFR-HAT-BAP was purified by Ni-NTA agarose, followed by buffer exchange to I-buffer, protease sensitivity of the precursor was compared depending on the presence of ...
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Mean cost per number needed to treat with tocilizumab plus methotrexate versus abatacept plus methotrexate in the treatment of rheumatoid arthritis in patients previously treated with methotrexate
... As indicated in the relative Summaries of Product Charac- teristics (SPC), both ABT (selective T-cell co-stimulation modulator) and TCZ (interleukin-6 receptor inhibitor) may be administered subcutaneously (sc) or ...
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Short time administration of antirheumatic drugs - Methotrexate as a strong inhibitor of osteoblast's proliferation in vitro
... of MTX on bone healing after tooth extractions, bony resections, and augmentations in reconstructive ...of MTX are barley avail- able ...if MTX means a contraindication for dental implantations or if ...
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Scavenger Receptor-Mediated Targeted Treatment of Collagen-Induced Arthritis by Dextran Sulfate-Methotrexate Prodrug
... detected in the Dex-g-MTX and free MTX group. To further confirm our findings, the relative expression areas of the three pro-inflammatory cytokines above were analyzed by ImageJ software (National ...
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Iron–gold alloy nanoparticles serve as a cornerstone in hyperthermia-mediated controlled drug release for cancer therapy
... NFA– MTX (M) both showed similar cytotoxicity, implying that a saturation level was ...study, MTX-conjugated NFAs can be successfully utilized to achieve controlled drug release via hyperthermia and target ...
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Mutations in the MTHFR gene are not associated with Methotrexate intolerance in patients with juvenile idiopathic arthritis
... considered MTX intolerant (MISS: median 11, range ...of MTX in- ...of MTX treatment and folic acid supplementation. Higher doses of MTX were non-significantly correlated with a lower frequency ...
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Interactions between detoxification mechanisms and excretion in Malpighian tubules of Drosophila melanogaster
... of MTX is 7- hydroxymethotrexate and both compounds are transported by MRP2 (Vlaming et ...liver, MTX may be metabolized by aldehyde oxidase and xanthine oxidase, but there is no evidence for interactions ...
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Microbubbles coupled to methotrexate-loaded liposomes for ultrasound-mediated delivery of methotrexate across the blood–brain barrier
... of MTX to the brain is achieved by high systemic doses, which cause severe long-term neurotoxicity, or intrathecal administration, which is highly invasive and may lead to infections or hemorrhagic ...to ...
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Interleukin 6 regulates anti arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model
... Glucose 6-phosphate isomerase (GPI)-induced arthri- tis is widely studied, not only for the understanding of the pathogenesis of RA, but also for the development of new therapeutics, because its pathological features are ...
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Optimal dose of etanercept in the treatment of rheumatoid arthritis
... (Shanghai CP Guojian Pharmaceutical Co. Ltd, Shanghai, People’s Republic of China) (a recombinant TNF receptor Fc fusion protein available in the People’s Republic of China that has the same structure as ETN) had better ...
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