mucosal-associated invariant T
Mucosal associated invariant T cell–rich congenic mouse strain allows functional evaluation
... Mucosal-associated invariant T cells (MAITs) have potent antimicrobial activity and are abundant in humans (5%–10% in ...the invariant TCR-α chain and restricting molecule MR1, this ...
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Recipient mucosal associated invariant T cells control GVHD within the colon
... conventional T cells, γδ T cells, and the recently described mucosal-associated invariant T (MAIT) cells (5–7), the latter of which are exquisitely positioned to respond to ...
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Activation status of mucosal associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus
... Fig. 5 Cytokine-mediated activation of mucosal-associated invariant T (MAIT) cells. a Correlation between the plasma levels of cytokines with the percentage of MAIT cells or CD69 expression on ...
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Clinical relevance of circulating mucosal-associated invariant T cell levels and their anti-cancer activity in patients with mucosal-associated cancer
... Mucosal-associated invariant T (MAIT) cells are an antimicrobial MR1-restricted T cell subset and play an important role in immune defense response to ...with ...
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MAXIMAL EXERCISE INCREASES MUCOSAL ASSOCIATED INVARIANT T CELL FREQUENCY AND NUMBER IN HEALTHY YOUNG MEN
... Mucosal associated invariant T (MAIT) cells have properties of both the innate and acquired immune ...specific T cell populations using flow ...total T cells significantly ...
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Mucosal associated invariant T cell alterations in obese and type 2 diabetic patients
... are associated with low-grade inflammation, activation of immune cells, and alterations of the gut ...microbiota. Mucosal-associated invariant T (MAIT) cells, which are innate-like ...
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Altered composition and phenotype of mucosal associated invariant T cells in early untreated rheumatoid arthritis
... MAIT: Mucosal-associated invariant T; MFI: Mean fluorescence intensity; MOI: Multiplicity of infection; MR1: MHC class I-related protein 1; NK: Natural killer; PB: Peripheral blood; PBMC: ...
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Harnessing the antibacterial and immunological properties of mucosal associated invariant T cells in the development of novel oral vaccines against enteric infections
... development. Mucosal-associated invariant T (MAIT) cells are a recently discovered population of unconventional T cells characterized by an evolutionarily conserved ab T cell ...
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Mucosal associated invariant T cells from human breast ducts mediate a Th17 skewed response to bacterially exposed breast carcinoma cells
... called mucosal associated invariant T cells (MAIT cells) ...innate T cells that recognize specific microbially synthesized precursors of riboflavin as antigens presented by the ...
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Persistent Changes in Circulating and Intestinal gamma delta T Cell Subsets, Invariant Natural Killer T Cells and Mucosal Associated Invariant T Cells in Children and Adults with Coeliac Disease
... mucosal associated invariant T cells, in blood and duodenum from adults and children with coeliac disease and healthy matched ...γδ T cell type in the adult epithelium and lamina ...
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Mucosal-Associated Invariant T cell in liver diseases
... Mucosal-associated invariant T cells (MAIT cells) are a new population of innate immune cells, which are abundant in the liver and play complex roles in various liver ...
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Human Leptin Hormone Affects TNF-α Production in Mucosal-associated Invariant T Cells
... Although Leptin’s effects on conventional T cells and regulatory T cells have investigated in recent years, in case of MAIT cells, very limited studies have been conducted [29]. In our study, it was shown ...
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CD4+/CD8+ mucosa-associated invariant T cells foster the development of endometriosis: a pilot study
... Mucosal-associated invariant T (MAIT) cells are non- classical T lymphocytes characterised by a semi- invariant T cell receptor (TCR) which has been evolu- tionarily ...
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Mucosal-associated invariant and γδ T cell subsets respond to initial Mycobacterium tuberculosis infection
... for cell culture. Cryopreserved healthy donor PBMCs were thawed and cultured in RPMI 1640 media (ATCC)/10% FBS and directly incubated with 2 μM 5-A-RU•H 2 O/50 μM MeG•H 2 O for 15 hours at 37°C as previously described ...
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Exogenous Activation of Invariant Natural Killer T Cells by α Galactosylceramide Reduces Pneumococcal Outgrowth and Dissemination Postinfluenza
... is associated with a strong reduction of bacterial outgrowth in the ...was associated with the activation of pulmonary iNKT cells (IFN-␥ and ...of mucosal bar- rier function (which enables bacterial ...
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Mucosa-Associated Invariant T Cells Are Systemically Depleted in Simian Immunodeficiency Virus-Infected Rhesus Macaques
... Although multiple studies have documented MAIT cell depletion in the peripheral blood of HIV-infected individuals (18–20), a clear understanding of the mechanisms that drive this phenome- non is lacking because ...
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Unusual primary HIV infection with colonic ulcer complicated by hemorrhagic shock: a case report
... We believe that PHI could be the cause of this colonic ulcer for a number of reasons. First, despite extensive investigations, we could not identify any alternative infectious or tumoral etiology. Even if “special ...
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Clonal analysis of CD4+ T cells
... Where clonal expansions have been reported in CD8^CD45RA^ cells they are usually found within distinct subsets of cells. Studies by Wills (Wills 2002) show that clonal expansions in CMV are within CD27^CD28‘ and ...
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Acute-Phase CD4+ T Cell Responses Targeting Invariant Viral Regions Are Associated with Control of Live Attenuated Simian Immunodeficiency Virus
... Acute-phase T cell responses elicited in M3/M3 MCMs infected with SIV ⌬ nef-8x target several viral regions that do not accumulate ...were T cell responses present in M3/M3 MCMs infected with SIVΔnef-8x ...
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Mucosal BCG Vaccination Induces Protective Lung Resident Memory T Cell Populations against Tuberculosis
... lung-infiltrating T cells were located in the lung parenchyma or the lung airways, we first removed the bronchoalveolar lavage fluid (BALF) and performed flow cytom- etry of the lung parenchyma ...tissue. ...
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