Mucosal associated invariant T cell
Mucosal-Associated Invariant T cell in liver diseases
... MAIT cell is essential and important to identify their function (Figure ...and T-bet transcription factor [11, 23], consequently regulating the rapid effector ...
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Clinical relevance of circulating mucosal-associated invariant T cell levels and their anti-cancer activity in patients with mucosal-associated cancer
... Mucosal-associated invariant T (MAIT) cells are an antimicrobial MR1-restricted T cell subset and play an important role in immune defense response to ...MAIT cell levels ...
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Mucosal associated invariant T cell–rich congenic mouse strain allows functional evaluation
... S. Grondin, and A. Viguier for cell sorting; T. Rio Frio of the Next-Generation Sequencing (NGS) platform for advice; D. Laubreton for technical help; A. Lehuen, X. Montagutelli, and G. Eberl for mice; and ...
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MAXIMAL EXERCISE INCREASES MUCOSAL ASSOCIATED INVARIANT T CELL FREQUENCY AND NUMBER IN HEALTHY YOUNG MEN
... MAIT cell response was determined in young males before and immediately after maximal exercise at two time ...While cell number increases, does exercise alter MAIT cell function ...MAIT cell ...
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Mucosal associated invariant T cell alterations in obese and type 2 diabetic patients
... Subjects were weight stable (±3 kg) for at least 3 months before the surgery. Seventeen (25%) of the subjects had T2D with a fasting glycemia >7 mmol/l and/or the use of an antidiabetic drug (n = 13, 19%). Patients ...
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Activation status of mucosal associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus
... and cell surface staining was performed using the following monoclonal antibodies (mAbs) and tetra- mers: TCR pan-γ/δ-fluorescein isothiocyanate (FITC), CD8β-phycoerythrin (PE)-Texas Red electron-coupled dye ...
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Human Leptin Hormone Affects TNF-α Production in Mucosal-associated Invariant T Cells
... regulatory T cells is better than recombinant ...the cell cultures has not affected the IL-2-mediated ...of T cell receptor engagement [35, ...MIAT cell has not investigated yet. In ...
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Altered composition and phenotype of mucosal associated invariant T cells in early untreated rheumatoid arthritis
... MAIT: Mucosal-associated invariant T; MFI: Mean fluorescence intensity; MOI: Multiplicity of infection; MR1: MHC class I-related protein 1; NK: Natural killer; PB: Peripheral blood; PBMC: ...
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Harnessing the antibacterial and immunological properties of mucosal associated invariant T cells in the development of novel oral vaccines against enteric infections
... location within the circulation and tissues to be characterized. However, it should be noted that as this classification strategy relies on reactivity with the anti-V a 7.2 mAb, and because this is not fully limited to ...
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CD4+/CD8+ mucosa-associated invariant T cells foster the development of endometriosis: a pilot study
... Mucosal-associated invariant T (MAIT) cells are non- classical T lymphocytes characterised by a semi- invariant T cell receptor (TCR) which has been evolu- ...
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Mucosal associated invariant T cells from human breast ducts mediate a Th17 skewed response to bacterially exposed breast carcinoma cells
... called mucosal associated invariant T cells (MAIT cells) ...innate T cells that recognize specific microbially synthesized precursors of riboflavin as antigens presented by the ...
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Mucosa-Associated Invariant T Cells Are Systemically Depleted in Simian Immunodeficiency Virus-Infected Rhesus Macaques
... MAIT cell depletion in the peripheral blood of HIV-infected individuals (18–20), a clear understanding of the mechanisms that drive this phenome- non is lacking because potentially relevant tissues are difficult ...
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Mucosal-associated invariant and γδ T cell subsets respond to initial Mycobacterium tuberculosis infection
... Statistics. Raw OTU count data was normalized using DESeq2 (94), and OTU abundances were indi- vidually correlated using Spearman correlation coefficients against the immunophenotypes described herein. Significant OTUs ...
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Persistent Changes in Circulating and Intestinal gamma delta T Cell Subsets, Invariant Natural Killer T Cells and Mucosal Associated Invariant T Cells in Children and Adults with Coeliac Disease
... of T cells into the small intestinal epithelium is one of the earliest events in CD development ...γδ T cells are present in this infiltrate, but while αβ T cell levels return to normal upon ...
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Recipient mucosal associated invariant T cells control GVHD within the colon
... The mucosal location of MAIT cells enables rapid sensing of any breakdown in mucosal surface integrity and subsequent bac- terial and/or PAMP molecule translocation, a prominent feature of ...of ...
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Mucosal BCG vaccination induces protective lung-resident memory T cell populations against tuberculosis
... memory T cells has been shown to be essential for protective TB ...by mucosal vaccination has been known to generate superior protection against TB in animal models; however, the mechanisms of protection ...
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CD4+ T Cells, Including Th17 and Cycling Subsets, Are Intact in the Gut Mucosa of HIV-1-Infected Long-Term Nonprogressors
... Subjects. Peripheral blood (PB) samples and colonic biopsy specimens were collected from 18 HIV-uninfected volunteers (HIV ⫺ ), 22 HIV-infected patients treated with prolonged ART with plasma HIV RNA less than 50 ...
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The transcription factor IFN regulatory factor–4 controls experimental colitis in mice via T cell–derived IL 6
... IRF4-deficient T cells resulted in severe ...from T cell–dependent chronic intestinal inflammation in trinitrobenzene sulfonic acid– and oxazolone-induced ...reduced mucosal IL-6 production, ...
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Mucosal and systemic T cell response in mice intragastrically infected with Neospora caninum tachyzoites
... vitro T-cell proliferation and cyto- kine ...and T conventional cells responsiveness, as may be suggested by the lower cytokine production of the MLN responder cells upon induction with anti-CD3 and ...
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Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis
... + T cells interacting with EBV-infected plasma cells in white matter has been associated with the active phase of MS ...memory T cells (for example, those that are specific to a multitude of ...
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