multicentric Castleman’s disease
Multicentric Castleman's Disease in a Hepatitis C-Positive Intravenous Drug User: A Case Report
... This case report of multicentric Castleman’s disease high- lights a number of emerging diagnostic and management issues with this condition. This patient was negative for both HIV and HHV-8, which ...
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Distinct features distinguishing IgG4 related disease from multicentric Castleman's disease
... IgG4-related disease; LDH, lactate dehydrogenase; MCD, multicentric Castleman’s disease; Plt, platelet; TP, total protein; TC, total cholesterol; WBC, white blood ...
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Multicentric Castleman’s disease with voltage-gated potassium channel antibody-positive limbic encephalitis: a case report
... A 47-year old Caucasian man with history of depression and remote polysubstance abuse presented to his primary care physician with two months of cough, dyspnea, and asthenia. Chest radiography demonstrated patchy, ...
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Detection of Chlamydophila pneumoniae and human herpesvirus 8 in primary cutaneous anaplastic large-cell lymphoma: a case report
... including Multicentric Castleman’s Disease (MCD), Primary Effusion Lymph- omas (PEL) and other lymphoproliferative disorders in immunosuppressed patients ...
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Cerebral angiitis associated with subarachnoid hemorrhage in Castleman’s disease: report of two cases
... Castleman’s disease (CD) was initially described by Ben- jamin Castleman et ...a disease with solitary hyperplastic mediastinal lymph nodes containing small, hyalinized follicles and a marked ...
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Quantitative Analysis of Human Herpesvirus 8 Viral Load Using a Real Time PCR Assay
... We have developed a quantitative real-time PCR (TaqMan) assay aimed at measuring the cellular human herpesvirus 8 (HHV-8) DNA load in various clinical samples. Standard curves were obtained by serial dilutions of a ...
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Relapses of primary cutaneous anaplastic large-cell lymphoma in a female immunocompetent patient with persistent chlamydophila pneumoniae and human herpesvirus 8 infection
... ’ s sar- coma (KS), Multicentric Castleman’s Disease (MCD), and Primary Effusion Lymphomas (PEL), and associated to other lymphoproliferative disorders occurring primar- ily in immunosuppresed ...
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Castleman’s Disease of the Pleura: Case Presentation and Review of Literature
... Castleman’s disease is a lymphoproliferative disorder characterized by enlarged hyperplastic lymph node(s) where there is a polyclonal B lymphocyte proliferation, often associated with autoimmune ...
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Diagnosis and treatment of CD20 negative B cell lymphomas
... CD20 negative B cell non-Hodgkin lymphoma (NHL) is rare and accounts for approximately 1-2% of B cell lymphomas. CD20- negative NHL is frequently associated with extranodal involvement, atypical morphology, aggressive ...
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Impact of siltuximab on patient-related outcomes in multicentric Castleman’s disease
... Abstract: Multicentric Castleman’s disease (MCD) is a rare, widespread lymphoproliferative disorder and a life-threatening disease involving hyperactivity of the immune system, excessive ...
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An unusual presentation of Castleman's Disease:a case report
... Hodgkin's disease, non-malignant lymphoma, and an infectious etiology, multicentric Cas- tleman's disease (MCD) remained the likely diagnosis in this ...
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A phase 2, open-label, multicenter study of the long-term safety of siltuximab (an anti-interleukin-6 monoclonal antibody) in patients with multicentric Castleman disease
... and disease characteristics were reported from the phase 1 study ...of disease control (specifically, proportions of previously- responding patients and siltuximab-naïve patients who maintained ...
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Castleman’s disease in the HIV-endemic setting
... and multicentric have specific systemic manifestations and could be associated with Kaposi sarcoma (KS), Hodgkin’s or non-Hodgkin’s lymphomas, as well as POEMS ...
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ADA2 Deficiency Mimicking Idiopathic Multicentric Castleman Disease
... Multicentric Castleman disease (MCD) is a rare entity that, unlike unicentric Castleman disease, involves generalized polyclonal lymphoproliferation, systemic inflammation, and ...
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Emerging treatments in Castleman disease – a critical appraisal of siltuximab
... Even in light of these inherent limitations, siltuximab appears to be a safe treatment option for treatment of HIV-negative, HHV-8-negative multicentric CD as evi- denced by the safety profiles in all three ...
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Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL 6 blockade–refractory idiopathic multicentric Castleman disease
... TAFRO syndrome clinical subtype of iMCD, and they were not selected at random. Sirolimus was administered to these patients because they shared clinicopathological features and cellular and molecular findings suggesting ...
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Tumor enucleation for Castleman’s disease in the pulmonary hilum: a case report
... Castleman’s disease (CD) is a rare disorder of lymph propa- gation first reported by Castleman and colleagues in 1954 from a case with chronic fever and mediastinal tumor ...The multicentric type, ...
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Hyaline vascular variant of unicentric Castleman disease of the tonsil: a case report
... but with solitary mediastinal lymphadenopathy [1]. These features were so distinctive that the type of dis- ease was later characterized as unicentric Castleman dis- ease (UCD). In 1978, Gaba et al. described a ...
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Retroperitoneal Castleman’s disease: advocating a multidisciplinary approach for a rare clinical entity
... Angiofollicular lymph node hyperplasia, or Castleman’s disease (CD), is a rare neoplastic disease first identified in 1956 by Castleman and colleagues [1]. It has been de- scribed mainly in case ...
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Case Report Clinical and radiological features of parapancreatic hyaline-vascular Castleman disease: a case report and literature review
... Castleman’s disease (LCD), only affects a group of lymph nodes, is defined as a single, benign lesion which usually affects young people [8, ...While multicentric Cas- tleman’s disease (MCD) which ...
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