Multidrug Resistance Protein
Membrane transport of camptothecin: facilitation by human P-glycoprotein (ABCB1) and multidrug resistance protein 2 (ABCC2)
... Results: The absorptive (apical to basolateral) and secretory (basolateral to apical) permeabilities of CPT were found to be saturable. Reduced secretory CPT permeabilities with decreasing temperatures suggests the ...
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Surveillance of artemether lumefantrine associated Plasmodium falciparum multidrug resistance protein 1 gene polymorphisms in Tanzania
... falciparum multidrug resistance protein-1 ( Pfmdr1 ) is an adenosine triphosphate-binding cassette protein located on the parasite’s food vacuole ...confer resistance against quinine ...
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Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood cerebrospinal fluid barrier
... Multidrug resistance protein 1 (MRP1) is a transporter protein that helps to protect normal cells and tumor cells against the influx of certain ...Mrp1 protein causes etoposide levels ...
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Molecular Modelling of Human Multidrug Resistance Protein 5 (ABCC5)
... Multidrug resistance protein 5 (MRP5/ABCC5) is a 161 kDa member of the super family of ATP- binding cassette (ABC) superfamily of transmembrane transporters that is clinically relevant for its ...
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Decreased functional activity of multidrug resistance protein in primary colorectal cancer
... Cancer Resistance Protein (BCRP) or MitoXantrone Resistance Protein (MXR); BMI: Body mass index; Calcein-AM: Calcein acetoxy methylester; CRC: Colo rectal cancer; CSC: Cancer stem cells; FSC: ...
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3D QSAR AND CONTOUR MAP ANALYSIS OF TARIQUIDAR ANALOGUES AS MULTIDRUG RESISTANCE PROTEIN 1 (MRP1) INHIBITORS
... is multidrug resistance of human cancer cells to anti-cancer ...to multidrug resistance is the human multidrug resistance protein-1 transporter (MRP1), which is an efflux ...
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Hypoxia-inducible factor-1α induces multidrug resistance protein in colon cancer
... Abstract: Multidrug resistance is the major cause of chemotherapy failure in many solid tumors, including colon ...tumor resistance to ...tumor resistance; however, the mechanism is still not ...
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Multidrug resistance protein 1 localization in lipid raft domains and prostasomes in prostate cancer cell lines
... Methods: MRP1 and caveolae protein markers were detected using confocal microscopy, per- forming colocalization techniques. Lipid raft isolation made it possible to detect these proteins by Western blot analysis. ...
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Regulation of expression of the multidrug resistance protein MRP1 by p53 in human prostate cancer cells
... Immunoblotting. Cell pellets were lysed on ice for 30 minutes with RIPA buffer (10 mM sodium phosphate [pH 7.2], 1% Nonidet P-40, 1% sodium deoxycholate, 0.1% SDS, 150 mM NaCl, and 2 mM EDTA) supple- mented with fresh 1% ...
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INFLUENCE OF MULTIDRUG RESISTANCE PROTEIN-2 GENETIC POLYMORPHISM ON THE PHARMACOKINETICS OF MYCOPHENOLATE MOFETIL IN THAI KIDNEY TRANSPLANT PATIENTS
... transporter, multidrug resistance- associated protein-2 (MRP-2), and is then converted to MPA via intestinal microflora -glucuronidase resulting in reabsorption of MPA into the systemic ...
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Multidrug resistance associated protein 4 is a bile transporter of Clonorchis sinensis simulated by in silico docking
... extreme environment, since accumulation of bile juice can be toxic to the worm’s tissues and cells [6]. Among the various bile juice, lithocholic acid (LCA) has been proven to have a toxic effect on the survival of ...
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Multidrug Resistance-Associated Protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and Buthionine Sulfoximine
... Multidrug resistance protein (MRP1) mediated drug resistance occurs against a broad spectrum of natural product drugs like vincristine, although the mechanisms have not been exactly understood ...
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Protein arginine methyltransferase 1 may be involved in pregnane x receptor-activated overexpression of multidrug resistance 1 gene during acquired multidrug resistant
... the protein samples was determined and standardized using the BCA Protein Assay Kit (Thermo Scientific, Waltham, MA, USA) according to the manufacturer’s ...Finally, protein concentration was ...
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miR-145 sensitizes breast cancer to doxorubicin by targeting multidrug resistance-associated protein-1
... Our results revealed that miR-145 expression level decreased significantly both in breast cancer tissues and breast cancer cell lines compared the control. In addition, our data showed that miR-145 expression level was ...
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Antibiotic strategies in the era of multidrug resistance
... Carbapenemase production by Gram-negative bacteria is one of the most concerning patterns of resistance encountered in the ICU because it is associated increas- ingly with resistance to all presently ...
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Lapatinib Antagonizes Multidrug Resistance-Associated Protein 1-Mediated Multidrug Resistance by Inhibiting Its Transport Function
... for multidrug resistance (MDR) in ...on multidrug resistance–associated protein 1 (MRP1 [ABCC1]), MRP2 (ABCC2), MRP4 (ABCC4) and lung rela- tive resistance protein (LRP) ...
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Basolateral localization and export activity of the human multidrug resistance associated protein in polarized pig kidney cells
... human multidrug resistance–associated protein MRP confers resistance to various cytotoxic drugs by lowering the intracellular drug ...drug resistance. ( J. Clin. Invest. 1996. ...
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Yeast ABC proteins involved in multidrug resistance
... drug resistance is a complex phenomenon that involves many proteins that together create a ...of multidrug resistance in eukaryotic cells is the active efflux of a broad range of xenobiotics through ...
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Multidrug resistance-associated protein 1 and lung function decline with or without long-term corticosteroids treatment in COPD
... Chronic Obstructive Pulmonary Disease (COPD) is an inflam- matory disease characterized by airflow limitation that is not fully reversible, progressive in nature and associated with an abnormal inflammatory response of the ...
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Multidrug resistance associated protein MRP 1 regulates dauer diapause by its export activity in Caenorhabditis elegans
... the multidrug resistance-associated proteins (MRPs) belonging to the ATP- binding cassette (ABC) transporter ...confers resistance to arsenite and cadmium ...
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