Multidrug-Resistant Mycobacterium tuberculosis
Evaluation of Microscopic Observation Drug Susceptibility Assay for Detection of Multidrug Resistant Mycobacterium tuberculosis
... of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) is of primary importance for both patient management and infection ...drug-resistant Mycobacterium tuberculosis ...
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Targeting multidrug resistant Mycobacterium tuberculosis htra2 with identical chemical entities of fluoroquinolones
... HtrA2 protein is one of the aetiologies for mycobacterium infections. Targeting this protein will be helpful in treating the infection caused by M. tuberculosis. Determining the binding structures in the ...
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Systematic Molecular Characterization of Multidrug Resistant Mycobacterium tuberculosis Complex Isolates from Spain
... Bacterial isolates and the Spanish MDR TB network. The Spanish MDR TB study group includes 118 mycobacteriology laboratories located within different hospitals in Spain ...
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Multicenter Evaluation of Genechip for Detection of Multidrug Resistant Mycobacterium tuberculosis
... Drug-resistant tuberculosis (TB), especially multidrug-resistant TB (MDR-TB), is still one of the most serious threats to TB con- trol ...
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Multidrug Resistant Tuberculosis in Panama Is Driven by Clonal Expansion of a Multidrug Resistant Mycobacterium tuberculosis Strain Related to the KZN Extensively Drug Resistant M tuberculosis Strain from South Africa
... Phylogenetic analysis of this sample of 66 drug-resistant strains from Panama revealed that nearly one-half of the cases of MDR-TB over the past decade have been caused by a single circu- lating strain, LAM9-c1. ...
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Genotyping Multidrug Resistant Mycobacterium tuberculosis from Primary Sputum and Decontaminated Sediment with an Integrated Microfluidic Amplification Microarray Test
... M. tuberculosis drug resis- tance and the host response indicate that next-generation ...M. tuberculosis diagnostics will require relatively high levels of multiplexing and an ability to specifically ...
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gyrA Gene Mutation Conferring Phenotypic Cross Resistance among Fluoroquinolones (Ofloxacin, Levofloxacin and Gatifloxacin) in Multidrug Resistant Mycobacterium tuberculosis Strains Isolated from Pulmonary MDR TB Patients in Bangladesh
... of multidrug resistant-tuberculosis (MDR-TB) treatment regimen but unfortunately the emergence of FLQ resistant MDR-TB cases is challeng- ing the current MDR-TB treatment ...
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Pyrazinamide Resistance among South African Multidrug Resistant Mycobacterium tuberculosis Isolates
... According to the drug resistance survey conducted from 2001 to 2002 (21) by the MRC, South Africa, isolates with resistance to isoniazid were detected in 5.7% of new patients and in 11.8% of patients with a previous ...
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Genetic Diversity of Multidrug Resistant Mycobacterium tuberculosis Isolates and Identification of 11 Novel rpoB Alleles in Taiwan
... were resistant to INH, RMP, and EMB and susceptible to SM) and had a single mutation at codon 531 (TCG3TTG, ...were resistant to all four drugs (except for one isolate, which was susceptible to EMB), all ...
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Genetic diversity and molecular epidemiology of multidrug resistant Mycobacterium tuberculosis in Minas Gerais State, Brazil
... A further characterization of the RIF-INH typing scheme (16-plex) was performed for 102 of 104 (98.7 %) isolates, either on the 81 base-pair RRDR for RIF or in inhA and katG for INH. For two isolates, none of the ...
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Molecular Markers Demonstrate that the First Described Multidrug Resistant Mycobacterium bovisOutbreak Was Due to Mycobacterium tuberculosis
... characterized multidrug-resistant Mycobacterium tuberculosis complex strains which caused a nosocomial outbreak of tuberculosis affecting six human immunodeficiency virus (HIV)-positive ...
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Structure-Antibacterial Activity Relationships Of N-Substituted-(D-/L-Alaninyl) 1H-1,2,3-Triazolylmethyl Oxazolidinones
... and multidrug-resistant Mycobacterium tuberculosis (MDR-TB) are among the troublesome pathogens within the healthcare and some community settings worldwide ...
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Sequence Analysis of Fluoroquinolone Resistance Associated Genes gyrA and gyrB in Clinical Mycobacterium tuberculosis Isolates from Patients Suspected of Having Multidrug Resistant Tuberculosis in New Delhi, India
... M. tuberculosis have been described for many populations in many studies (5, 17–23); however, information on mutations in the gyrA and gyrB genes from the Indian subcontinent is scarce (24, 25), although India has ...
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Drug resistance patterns of Mycobacterium tuberculosis complex and risk factors associated with multidrug-resistant tuberculosis in the upper southern part of Thailand
... The second highest any resistance was against rifampicin 10.8%. This is in agreement with the study in Hangzhou, China 10.2% [18]. The higher rate of rifampicin resistance might be due to its adverse effects such as ...
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Mycobacterium tuberculosis Beijing Lineage Favors the Spread of Multidrug Resistant Tuberculosis in the Republic of Georgia
... Drug-resistant Mycobacterium tuberculosis complex (MTBC) strains have emerged worldwide as a serious threat for tuber- culosis (TB) ...of multidrug-resistant (MDR) strains ...
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Rational Design of Biosafety Level 2 Approved, Multidrug Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy
... ABSTRACT Multidrug-resistant (MDR) tuberculosis, defined as tuberculosis resistant to the two first-line drugs isoniazid and rifampin, poses a serious problem for global ...
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Molecular Characterization of Multidrug and Extensively Drug Resistant Mycobacterium tuberculosis Strains in Jiangxi, China
... M. tuberculosis (26, ...four resistant strains, which each had another mutation within the RRDR of rpoB (Table ...M. tuberculosis strains from Jiangxi province, because a relatively smaller number of ...
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Multidrug resistant tuberculosis
... year, tuberculosis remains one of the most feared diseases on the ...of Mycobacterium tuberculosis that are resistant to the major anti- tuberculosis drugs poses a deadly threat to ...
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Evaluation of Etest for Susceptibility Testing of Multidrug Resistant Isolates of Mycobacterium tuberculosis
... The Etest was proven to yield reproducible results using a sample of isolates chosen randomly. However, it was observed that when the discrepancies between Etest and the proportion method were reevaluated, the result ...
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Multiplex PCR assay specific for the multidrug resistant strain W of Mycobacterium tuberculosis
... Because the three sets of primers were used in the same PCR mixture as a multiplex PCR, a strain W isolate was expected to produce all three amplicons; the 175-bp and 223-bp products, wh[r] ...
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