Multipotent Mesenchymal Stromal Cells
Cytoplasmic-targeted parvalbumin blocks the proliferation of multipotent mesenchymal stromal cells in prophase
... Introduction: Multipotent mesenchymal stromal cells (MSCs) have gained considerable interest because of their potential use in the treatment of a variety of diseases and ...of cells ...
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Placenta-derived multipotent mesenchymal stromal cells: a promising potential cell-based therapy for canine inflammatory brain disease
... IBD is a general term used to describe an idiopathic disorder that can be subdivided based on histopathology findings, i.e., granulomatous meningoencephalomyelitis (GME), necrotizing meningoencephalitis (NME), and ...
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HLA-DR expression in clinical-grade bone marrow-derived multipotent mesenchymal stromal cells: a two-site study
... needed, cells were further expanded in vitro up to sufficient numbers (always under passage 4) using Dulbecco’s modified Eagle’s medium (DMEM; Gibco) supplemented with 10% human serum B (hSerB) containing 2 mM ...
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Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice
... glial cells, and that visual deficits in the early stage of DR are correlated with retinal neurosensory dysfunction that is mainly related to the early loss of RGCs [8, ...beta cells, allowing the ...
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The therapeutic potential of three-dimensional multipotent mesenchymal stromal cell spheroids
... of multipotent mesenchymal stromal cells (MSCs) is often insufficient due to harsh conditions present within the target tissue including hypoxia, low nutrient supply as well as inflammatory ...
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Multipotent stromal cells/mesenchymal stem cells and fibroblasts combine to minimize skin hypertrophic scarring
... Here, we tested the hypothesis that these two cell types would act synergistically to improve the quality of healing by communicating to appropriately educate the native wound microenvironment. A combined MSC + ...
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Mesenchymal stem cells/multipotent stromal cells (MSCs) are glycolytic and thus glucose is a limiting factor of in vitro models of MSC starvation
... these cells by engineering the matrix to present tethered EGFR ligand [12, ...such cells in the presence of low to minimal ...stem cells are likely to be a sim- ultaneous myriad, including loss of ...
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Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation
... the cells produce a more robust adipogenic dif- ferentiation over the course of 30 ...the cells from immediately cycling autopha- gosomes as they normally do may in fact allow the ...
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The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open label pre test: post test study with blinded outcome assessments
... MSC: Mesenchymal Stem Cell / Multipotent mesenchymal stromal cell; MSCIMS: The mesenchymal stem cells in multiple sclerosis trial; MSFC: Multiple sclerosis functional composite ...
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Regenerative medicine in the treatment of idiopathic pulmonary fibrosis: current position
... specifically mesenchymal stem cells (MSCs), a multipotent stromal cell population, which have demonstrated promising data in multiple animal models of pulmonary fibrosis ...the cells ...
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Hierarchy of mesenchymal stem cells: Comparison of multipotentmesenchymal stromal cells with fibroblast colony forming units
... stem cells is still obscure. Two types of human stromal precursor cells are ...system: mesenchymal multipotent stromal cells (MMSC) and fibroblast colony forming units ...
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Human adult stem cells derived from adipose tissue and bone marrow attenuate enteric neuropathy in the guinea-pig model of acute colitis
... stem cells (MSCs) otherwise known as multipotent stromal cells have been proposed as a potential treatment option for chronic inflammation and neurological damage ...These cells are ...
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Allogeneic Guinea pig mesenchymal stem cells ameliorate neurological changes in experimental colitis
... decade, mesenchymal stem cells (MSCs), also known as multipotent stromal cells, have emerged as a clinically viable therapy for many diseases, includ- ing IBD ...
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Effects of Transplantation with Marrow Derived Mesenchymal Stem Cells Modified with Survivin on Renal Ischemia Reperfusion Injury in Mice
... marrow mesenchymal stem cells were round and suspended as single cells in cul- ture ...long-spindle cells (Fig. 1B). Pas- saged cells (mostly spindle cells) were uniformly ...
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Directing three-dimensional multicellular morphogenesis by self-organization of vascular mesenchymal cells in hyaluronic acid hydrogels
... bone cells after 15 days (Additional file 2: Figure ...dissociated cells from 2D monolayer culture has the potential to enhance the VMCs’ survival and proangiogenic potential upon implantation into a bone ...
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Successful integration of transplanted mesenchymal stem cells into the livers of Schistosoma mansoni infected mice
... MSCs may also protect against S. mansoni-induced liver fibrosis by altering the microenvironment of the liver at sites of engraftment. This microenvironment is supposed to be improved in presence of PZQ, since it was ...
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First-in-man intravenous implantation of stromal vascular fraction in psoriasis: a case study
... This first-in-man case demonstrated the safety and feasibility of IV injection of SVF in a severe psoriasis patient. There were no major safety events, and the protocol was well tolerated. In addition, the patient ...
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Gene markers of cellular aging in human multipotent stromal cells in culture
... contaminating cells because of the variability in isolation methods and culturing proce- dures, which can greatly influence their ...of cells by adhesion characteristics, flow cy- tometry, or immunomagnetic ...
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Comparative analysis of curative effect of bone marrow mesenchymal stem cell and bone marrow mononuclear cell transplantation for spastic cerebral palsy
... This study concludes, in terms of gross motor function, 3 months after transplantation, the BMMSC group and the BMMNC group begin to gain significant improve- ments (A, B, and C dimensions and GMFM total scores). These ...
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Defined three-dimensional culture conditions mediate efficient induction of definitive endoderm lineage from human umbilical cord Wharton’s jelly mesenchymal stem cells
... insulin-producing cells in vitro ...insulin-producing cells with islet-like morph- ology, using recombinant adenovirus–PDX1 gene constructs [13, ...stem cells, adherence to clinical scale standards ...
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