Murine AIDS
The murine AIDS defective provirus acts as an insertional mutagen in its infected target B cells.
... In susceptible mice, the murine AIDS (MAIDS) defective virus can induce marked expansion of its target cells, the majority of which belong to the B-cell lineage. This expansion, which appears to be critical ...
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Susceptibility of inbred strains of mice to murine AIDS (MAIDS) correlates with target cell expansion and high expression of defective MAIDS virus.
... 4 0022-538X/92/042398-09$02.00/0 Copyright X 1992, American Society for Microbiology Susceptibility of Inbred Strains of Mice to Murine AIDS MAIDS Correlates with Target Cell Expansion a[r] ...
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The murine AIDS virus Gag precursor protein binds to the SH3 domain of c-Abl.
... Murine AIDS (MAIDS) is a severe immunodeficiency dis- ease characterized by lymphadenopathy, splenomegaly, hyper- gammaglobulinemia, T- and B-cell dysfunctions, and late ap- pearance of B-cell lymphomas and ...
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Modulation of murine AIDS-related pathology by concurrent antibody treatment and coinfection with Leishmania major.
... of murine leukemia viruses (MuLVs) designated LP-BM5 MuLV leads to a disease characterized by progressive immunodeficiency and lymphoproliferation, known as murine AIDS ...
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Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas.
... eloid tumors are primarily full-length ecotropic proviruses, which is consistent with the postulated causative role of eco- tropic viruses in BXH-2 disease. It appears, therefore, that there is something special about ...
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Presence of transplantable T-lymphoid cells in C57BL/6 mice infected with murine AIDS virus.
... 9 0022-538X/92/095691-05$02.00/0 Copyright © 1992, American Society for Microbiology Presence of Transplantable T-Lymphoid Cells in C57BL/6 Mice Infected with Murine AIDS Virus YOSHINAO [r] ...
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Murine AIDS is initiated in the lymph nodes draining the site of inoculation, and the infected B cells influence T cells located at distance, in noninfected organs.
... With replication-competent stocks of the defective murine AIDS virus used for inoculation, it was reported previously that the Ly-1+ B-cell population was infected by the defective virus[r] ...
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Evidence that the murine AIDS defective virus does not encode a superantigen.
... The T-cell receptor repertoire was analyzed in C57BL/6 mice upon infection with helper-free stocks of the pathogenic murine AIDS (MAIDS) defective virus in order to demonstrate if, as previously reported, ...
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Alpha/beta interferons increase host resistance to murine AIDS.
... Retrovirus-induced murine AIDS (MAIDS) is caused by LP-BM5 murine leukemia virus (MuLV) and exhibits many similarities to the human AIDS-related complex ...
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The Role of CD4 T Cells in the Pathogenesis of Murine AIDS
... fective murine leukemia virus (BM5def) that requires the rep- lication-competent ecotropic helper virus BM5eco for its entry into cells and spread in ...ensuing AIDS variety, termed murine ...
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High frequency of transmission of murine AIDS virus in C57BL/10 mice via mother's milk.
... In conclusion, this study demonstrates that the maternal transmission of LP-BM5 MuLV is mediated by mother's milk and that the transmission of MAIDS occurred with a high frequency and co[r] ...
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Studies of the susceptibility of nude, CD4 knockout, and SCID mutant mice to the disease induced by the murine AIDS defective virus.
... To determine whether CD41 T cells are essential for the infection of target B cells, C57BL/6 CD42/2 knockout mice n 5 10 and their control heterozygote or normal n 5 19 littermates were [r] ...
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Myristylation of Pr60gag of the murine AIDS-defective virus is required to induce disease and notably for the expansion of its target cells.
... To determine whether the potential to induce the proliferation of the infected target B cells was altered in the MyrMAIDS defective virus, equal titers of helper-free stocks of the mutan[r] ...
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Murine AIDS is an antigen-driven disease: requirements for major histocompatibility complex class II expression and CD4+ T cells.
... Second, B6 mice reconstituted with C2K/O bone marrow cells had normal frequencies of B cells class II negative and CD4+ cells and expressed high levels of BM5def transcripts but did not [r] ...
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The majority of cells infected with the defective murine AIDS virus belong to the B-cell lineage.
... To determine whether a clonal expansion of the infected target cells in mice inoculated with the chimeric or tagged defective viruses could be observed, as we had previously found to be [r] ...
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The MA (p15) and p12 regions of the gag gene are sufficient for the pathogenicity of the murine AIDS virus.
... In contrast to the previous observation 15, we have not yet been able to show that the expression of Pr609'9 in B cells transfected with BM5d/JP-1 leads to the stimulation of splenocyte [r] ...
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CD28-B7 Costimulatory Blockade by CTLA4Ig Delays the Development of Retrovirus-Induced Murine AIDS
... induction and progression. A preliminary observation of increased expression of B7 molecules on B cells in MAIDS prompted us to address the possible involvement of the CD28/B7 costimulatory pathway in MAIDS. Mice ...
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The p15gag and p12gag regions are both necessary for the pathogenicity of the murine AIDS virus.
... Because the HGB-1, HGB-2, HGB-4, and HGB-5 recombinant viruses were replication defective, cell clones expressing the chimeric viruses were superinfected with the replication-competent h[r] ...
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Expression of defective virus and cytokine genes in murine AIDS.
... While low levels of IRF-1 mRNA were detected in tissues of normal mice data not shown, the levels of IRF-1 mRNA in spleen, lung, lymph nodes, and thymus were significantly increased at 1[r] ...
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Queer Feelings, Political Potential: Tracing Affect in Performance Spaces
... LIST OF ABBREVIATIONS Cytomegalovirus CMV Human cytomegalovirus HCMV Murine cytomegalovirus MCMV Human Immunodeficiency Virus HIV Acquired Immune Deficiency Syndrome AIDS Murine AIDS MAI[r] ...
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