murine models
Determinants of Bluetongue Virus Virulence in Murine Models of Disease
... In order to begin to understand the molecular basis of BTV virulence, we have taken advantage of recently devel- oped experimental murine models of BTV infection (18, 33). We used 12 strains of BTV and ...
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Finding a needle in a haystack: whole genome sequencing and mutation discovery in murine models
... mutations in APL. They performed whole genome sequencing and copy number analysis of a well-characterized APL mouse model to uncover somatic mutations in Jak1 and lysine (K)-specific demethylase 6A (Kdm6a, also known as ...
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Radiation Induced Lung Cancers in Murine Models
... to murine models of radiation-induced lung ...mouse models, and xenograft models are outside of the scope of this ...excluded models requiring supplemental treatment in addition to ...
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Radiation-induced myeloid leukemia in murine models
... best models available for the study of carcinogenesis and its corresponding ...contains murine models that range from specific carcinogen-inducible tumors, to xenograft models fully compatible ...
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Murine Models of Candida Gastrointestinal Colonization and Dissemination
... the murine gut ...the murine gut ...In murine models, dectin-1 is necessary for controlling Candida in- fections in both the oral and vaginal mucosa (81, ...
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Immunocompetent murine models for the study of glioblastoma immunotherapy
... for murine models of glioma can be classified in three ways: 1) implantation of syngeneic primary tumor cells or cultured cell lines into immunocompetent hosts, 2) implantation of human gli- oma cells into ...
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TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection
... animal models of SARS-CoV and MERS-CoV infection to investi- gate the role of ...of murine models infected by SARS-CoV and MERS-CoV and in the resulting ...
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Lupus and proliferative nephritis are PAD4 independent in murine models
... Though recent reports suggest that neutrophil extracellular traps (NETs) are a source of antigenic nucleic acids in systemic lupus erythematosus (SLE), we recently showed that inhibition of NETs by targeting the NADPH ...
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Algorithms to predict cerebral malaria in murine models using the SHIRPA protocol
... The SHIRPA protocol is reproducible across time and laboratories [29,30] and it is a reliable tool for the evaluation of the neurological function in murine models of human disease [26,31-36]. Lackner et al ...
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Nonproteolytic Properties of Murine Alternatively Spliced Tissue Factor: Implications for Integrin-Mediated Signaling in Murine Models
... cant adhesion-independent role in pan- creatic cancer (44). masTF appears to act as a cell agonist by ligating β3 integrins on ECs, which activates the NF-κB path- way (Figure 5A). The β3-asTF nexus may thus promote ...
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Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease.
... AD models exhibit neuronal loss [39], with it being rarely reported in APP models, such as PDAPP and Tg2576 [67, 72], but more often reported in APP models combined with PSEN1 gene mutations ...
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Analysis of Axin2 expression and function in murine models for pancreatic cancer
... Tubular complexes with strong β-galactosidase staining were not observed in the pancreas of sham or STZ treated Axin2 + /lacZ mice, but in the pancreas of normoglycemic as well as hy[r] ...
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Murine models of Omenn syndrome
... mouse models bearing mutations in the V(D)J recombi- nase analogous to those causing human OS have been shown to recapitulate the disease and provide insight into the genesis of immunodeficiency com- bined with ...
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Evaluation of therapeutic effects of FAK inhibition in murine models of atherosclerosis
... The effect of a selective FAK inhibitor, Compound 12 [6] was evaluated in apoE KO and LDLr KO mouse spon- taneous models of atherosclerosis in 2 different designs, prevention and therapeutic intervention trials. ...
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Mechanisms of vascularization in murine models of primary and metastatic tumor growth
... However, the vascu‑ lature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; instead, malignant tumors can acquire blood vessels via alternative [r] ...
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B cell depletion in autoimmune diabetes:insights from murine models
... Elegant models using transgenic B cells indicate that B cells specific for autoantigen may serve as important APCs early on, even before DCs take on this role ...
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Cardiac Effects Of Huntington’s Disease In Murine Models
... Huntington’s disease (HD) is an autosomal dominant disease known for its severe neurologic phenotype. However, the causative protein in HD, mutant huntingtin (mHTT), is widely expressed across tissue types and may have ...
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Original Article Expression of fatty acid synthase in nonalcoholic fatty liver disease
... experimental murine models and in livers of patients with NAFLD in ...in murine and human NASH did not differ signifi- cantly from levels in normal liver ...vivo models of hepatic steatosis ...
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Species Identification and Virulence Attributes ofSaccharomyces boulardii (nom inval )
... mouse models of systemic disease and showed intermediate virulence compared with virulent and avirulent strains of ...in murine models of systemic ...
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Bridging infectious disease vaccines with cancer immunotherapy: a role for targeted RNA based immunotherapeutics
... in murine models, and induce suppression of metastatic spread in a murine melanoma model ...a murine melanoma model ...a murine model for respiratory syncytial infection ...
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