Murine neuroblastoma
Viologen-phosphorus dendrimers exhibit minor toxicity against a murine neuroblastoma cell line
... Other than the results of simple cytotoxicity assays, there have been no reports on the influence of viologen-phosphorus structures on the cell condition and basic functions. This inclined us to continue studies on VPD ...
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Proteomics Analysis of the Expression of Neurogranin in Murine Neuroblastoma (Neuro-2a) Cells Reveals Its Involvement for Cell Differentiation
... Although the biochemical properties of Ng have been well studied, its physiological function and mo- lecular mechanism are still not clearly elucidated. Pre- vious attempt to identify the proteins interacting with Ng ...
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Combined innate and adaptive immunotherapy overcomes resistance of immunologically cold syngeneic murine neuroblastoma to checkpoint inhibition
... syngeneic murine neuroblastoma model by transducing GD2 and GD3 synthase genes into 9464D neuroblast- oma cells (referred to as ...another neuroblastoma model, NXS2, which expresses GD2 and has a ...
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Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins.
... The argument that PrPSC is an integral component of the infectious scrapie prion is now supported by seven distinct experimental observations: i PrP 27-30 and scrapie prions copurify; Pr[r] ...
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Heterologous PrP molecules interfere with accumulation of protease-resistant PrP in scrapie-infected murine neuroblastoma cells.
... Uncloned Sc+-MNB cultures which expressed one of three different PrP molecules were assayed for expression of total PrP-res, using polyclonal rabbit antibody R.27.. Cells which expressed[r] ...
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Immune modulating effects of cyclophosphamide and treatment with tumor lysate/CpG synergize to eliminate murine neuroblastoma
... Lysate/CpG provides protection from live tumor challenge and delays progression of established tumor To begin, a tumor challenge model was used to rapidly assess the relevance of using tumor lysate and CpG for the ...
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Isolation of cold-sensitive mutants of measles virus from persistently infected murine neuroblastoma cells.
... Infection of NS20Y neuroblastoma cells with the cold-sensitive virus isolates resulted in the development of an immediate persistent infection, whereas infection of Vero or HeLa cells re[r] ...
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Targeted enhancement of the biological activity of the antineoplastic agent, neocarzinostatin Studies in murine neuroblastoma cells
... mercaptodopamine, a thiol-containing dopamine analogue, we have been able to enhance neocarzinostatin toxicity for cells of the neural crest tumor neuroblastoma. Thiol compounds that are not neurotransmitter ...
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Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3 hydroxy 3 methylglutaryl coenzyme A reductase
... 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase catalyzes the formation of mevalonate, an essential precursor for isoprenoid compounds in mammalian cells. Recent studies have shown that mevinolin, a competitive ...
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A single hamster PrP amino acid blocks conversion to protease-resistant PrP in scrapie-infected mouse neuroblastoma cells.
... scrapie-infected murine neuroblastoma cells has en- abled us to define an amino acid in the PrP gene sequence which has a significant effect on the conversion of PrP-sen to ...
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A Single Codon in the Nucleocapsid Protein C Terminus Contributes to In Vitro and In Vivo Fitness of Edmonston Measles Virus
... transgenic murine neuroblastoma cells. hsp72 transgenic murine neuroblastoma cells (ATCC CCL-131, also designated Neuro-2a or N2a) were established by stable transfection to constitutively ex- ...
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Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression
... a murine neuroblastoma cell line, suggesting that the compounds identified may not have sufficient efficacy in mouse model systems, despite efficacy in two different human CNS derived cell ...
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Pyrimidine base degradation in cultured murine C 1300 neuroblastoma cells and in situ tumors
... Dihydropyrimidine dehydrogenase DPD, the initial, rate-limiting step in pyrimidine degradation, was studied in two cell lines of murine neuroblastoma MNB-T1 and MNB-T2 that were derived [r] ...
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Prion Infection of Muscle Cells In Vitro
... culture. Murine C2C12 skeletal myoblast cells (American Type Culture Collection, Manassas, VA) were cultured in high-glucose Dulbecco modified Eagle medium (DMEM) (Invitrogen, Carlsbad, CA) supplemented with 10% ...
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Over-expression of AhR (aryl hydrocarbon receptor) induces neural differentiation of Neuro2a cells: neurotoxicology study
... neurogenesis, neuroblastoma is widely used as an experimental model. Neuroblastoma usually arises from the proliferation of neural crest-derived precursors resulting in defective differentiation in vivo ...
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Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1.
... In summary, tat2 86 and its peptide derivatives containing the basic domain can i specifically bind to rat brain synaptosomal membranes, rat glioma cells, and murine neuroblastoma cells,[r] ...
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Su, Baowei (2011): Treatment of cancer with combined chemo-gene therapy based on TNFα polyplexes and liposomal doxorubicine. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... metastatic murine neuroblastoma model, and that combining liposomal chemotherapeutic with TNF gene therapy leads to a synergistic effect on tumor reduction in both subcutaneous and metastatic murine ...
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Identification of alpha,beta-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells
... in murine neuroblastoma cell line Neuro-2a and found that RA elevated cellular 2-AG levels in Neuro-2a cells during differentiation and recombinant expression of DAGLα or DAGL β increased neurite outgrowth, ...
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Expression of Chemokine Receptor CXCR4 in Primary and Metastatic Neuroblastoma Expression of CXCR4 in Neuroblastoma
... of neuroblastoma disease describes the extent of primary tumor growth and how far the disease is spread to regional lymph node and metastasizes to distant sites such as bone and bone ...International ...
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Oncogene MYCN regulates localization of NKT cells to the site of disease in neuroblastoma
... oncogene, neuroblastoma derived (MYCN), the hallmark of aggressive neuroblastoma, repressed expression of monocyte chemoattractant protein–1/CC chemokine ligand 2 (MCP-1/CCL2), a che- mokine required for ...
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