Muscarinic receptor
TRACHEAL RESPONSIVENESS TO METHACHOLINE AND MUSCARINIC RECEPTOR BLOCKADE BY ATROPINE IN ANIMAL MODEL OF COPD
... at muscarinic receptors than tracheal response to methacholine in tracheal chains of exposed guinea pigs to cigarette smoke compared to control animals ...and muscarinic receptor blockade in both ...
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Pro-inflammatory mechanisms of muscarinic receptor stimulation in airway smooth muscle
... of muscarinic receptors in hASMc facilitates the secretion of the pro-inflammatory cytokines IL-6 and IL-8 in combination with CSE and pro-inflammatory ...cytokines. Muscarinic receptor stimu- lation ...
10
Honokiol blocks store operated calcium entry in CHO cells expressing the M3 muscarinic receptor: honokiol and muscarinic signaling
... activity, muscarinic receptor binding, or muscarinic signaling as reflected in either calcium mobilization or alteration of cAMP synthesis in response to ...carinic receptor subtypes respond ...
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Impaired vascular responses to parasympathetic nerve stimulation and muscarinic receptor activation in the submandibular gland in nonobese diabetic mice
... Functional blood flow studies have previously not, to our knowledge, been performed in NOD mice. In the present study, reduced responses to parasympathetic stimulation and to muscarinic receptor stimulation ...
12
MUSCARINIC RECEPTOR SUBTYPES IN SMOOTH MUSCLE FROM THE BODY OF HUMAN STOMACH
... Atropine, trihexyphenidyl, pirenzepine, telenzepine, hexocyclium, gallamine and scopolamine butylbromide concentration-dependently blocked tonic contractions of isolated preparations of both circular and longitudinal ...
8
The GAR-3 Muscarinic Receptor Cooperates With Calcium Signals to Regulate Muscle Contraction in the Caenorhabditis elegans Pharynx
... havior. Gomeza, J., L. Zhang, E. Kostenis, C. C. Felder, F. P. Bymaster et al., 2001 Generation and pharmacological analysis of M2 and We thank Joseph Dent for critical reading of the manuscript. We M4 muscarinic ...
12
M4 muscarinic receptor knockout mice display abnormal social behavior and decreased prepulse inhibition
... Muscarinic receptor involvement in the CNS has been indicated in spatial learning and encoding of new episo- dic memory based on various lines of ...
10
SENSITIVE SPECTROPHOTOMETRIC ASSAY OF MUSCARINIC RECEPTOR ANTAGONIST TOLTERODINE TARTRATE IN BULK DRUG AND PHARMACEUTICAL FORMULATIONS
... competitive muscarinic receptor antagonist used for the treatment of urinary incontinence (incontinence in detrusor instability) and other overactive bladder symptoms, such as urgency and high micturition ...
7
Muscarinic receptor modulation of basal and beta adrenergic stimulated function of the failing human left ventricle
... this receptor pathway upregulation was also demonstrated in that muscarinic stimulation in animals with heart failure resulted in greater inhibition of adenylate cy- clase activity and myocardial ...
9
Muscarinic receptor signaling in the pathophysiology of asthma and COPD
... on muscarinic receptors, may contribute to the pathophysiology and pathogenesis of asthma and COPD to a much larger extent than is currently ...novel muscarinic receptor signaling mechanisms in ...
15
Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor
... First, we investigated the importance of the 5- and 8-fluoro groups on the BQCA scaffold, with compounds, 5b-d, 6b-d and 7, as well as the previously reported 5a and 6a. The ester precursors 3a-d and 4a-d were also ...
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Regulation of m4 muscarinic receptor gene expression
... on muscarinic receptor regulation in cultured heart cells and neuroblastoma cell lines, in response to carbachol, have suggested a model for this ...
125
Impaired cardiac muscarinic receptor function in dogs with heart failure
... pmol/mg, with no change in antagonist affinity. However, agonist competition studies with both carbachol and oxotremorine showed that it was a loss of high affinity agonist binding sites in the sarcolemma from failing LV ...
8
A novel mechanism of hippocampal LTD involving muscarinic receptor-triggered interactions between AMPARs, GRIP and liprin-α
... of muscarinic receptor activation to modulate NMDAR-dependent synaptic plas- ticity and to induce synaptic plasticity in an NMDAR- independent manner are both important aspects of this ...
12
Muscarinic receptor activation of the MAP kinase signalling pathway and its physiological consequences
... Recent evidence has uncovered another novel role of the signalling molecules involved in receptor internalisation. Endocytosis has been shown to be important in the activation of MAPK (Daaka et al, 1998; Luttrell ...
255
Association of autoantibodies against the M2 muscarinic receptor with perinatal outcomes in women with severe preeclampsia
... Abstract Background: The goal of this study was to test the hypothesis that autoantibodies against M2-muscarinic acetylcholine receptor M2-AAB are associated with severe preeclampsia and[r] ...
7
Overexpression of M3 Muscarinic Receptor Is a Novel Strategy for Preventing Sudden Cardiac Death in Transgenic Mice
... Here we demonstrate that cardiac overexpression of M 3 -mAChR plays a critical role in the reduction of the inci- dence of arrhythmias and mortality in a mouse model by protecting the my[r] ...
9
Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways
... muscarinic activation of M 2 R-and M 3 R-transfected HEK293 cells stimulates S1P synthesis [4,5]. In the present study we therefore tested the hypothesis that acti- vation of the SPHK/S1P signalling pathway may ...
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PHARMACOLOGICAL AND ELECTROPHYSIOLOGICAL CHARACTERIZATION OF A POSTSYNAPTIC MUSCARINIC RECEPTOR IN THE CENTRAL NERVOUS SYSTEM OF THE COCKROACH
... using muscarinic antagonists, such as quinuclidinyl benzilate (Dudai and Ben-Barak, 1977; Breer, 1981; Aguilar and Lunt, 1984; Lummis and Sattelle, 1985; Huang and Knowles, 1990b; Abdallah et ...1991). ...
22
Upregulation of M3 muscarinic receptor inhibits cardiac hypertrophy induced by angiotensin II
... a, b Western blot analysis of M3-mAChR and M2-mAChR protein levels in ventricular tissues from mice with chronic angiotensin II Ang II 0.6 mg/kg per day infusion for 14 days n = 4 mice p[r] ...
8