muscle biopsies
Deep morphological analysis of muscle biopsies from type III glycogenesis (GSDIII), debranching enzyme deficiency, revealed stereotyped vacuolar myopathy and autophagy impairment
... 30 muscle biopsies. Age at muscle biopsy was available in 27 patients and ranged from 3 years to 59 years (median 38 ...Open muscle biopsies were obtained from different muscles ...
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The value of muscle biopsies in Pompe disease: identifying lipofuscin inclusions in juvenile- and adult-onset patients
... of muscle biopsies in LOPD is rightly ques- tioned in the Pompe disease community ...clinician, muscle biopsies are not reliable for diagnostic purposes, do not always serve as a prognos- tic ...
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Passive mechanical features of single fibers from human muscle biopsies – effects of storage
... OCT-embedded muscle biopsies were cut in a cryostat (Microm HM 500, Walldorf, Germany) in 10 μm thick sections and put on microscope slides and stained with Haematoxylin & Eosin ...attached. ...
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The Role of Electron Microscopy in the Assessment of Dermatomyositis: A Retrospective Pilot Study on Skeletal Muscle Biopsies
... Samples from each case were submitted for light and ultrastructural examination. Three microns thick sections were made using the formalin fixed, paraffin embedded tissue of the skeletal muscle samples. They were ...
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11β-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation
... Figure 4. Levels of mRNA in primary cultures of differentiated myotubes isolated from quadriceps muscle biopsies from WT mice (A–C) and human quadriceps biopsies (F–H) (n = 3 per variable), ...
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Lack of robust satellite cell activation and muscle regeneration during the progression of Pompe disease
... skeletal muscle biopsies from Pompe patients are similar to ...extensive muscle pathology, espe- cially in classic infantile ...in muscle biopsies from clinically severely affected ...
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Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy
... skeletal muscle suggests that these proteins may represent viable biomarkers in human SMA ...of muscle biopsy, as well as the small sample ...skin biopsies might be of more practical use for these ...
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Ultrastructural Aspects of Apoptosis in Systemic Sclerosis Inflammatory Myopathy
... Muscle biopsies from two female patients with systemic sclerosis (SS) and an inflammatory myopathy were studied ultrastructurally in relation to the poss- ible presence of apoptosis in skeletal ...
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Hematopoietic cell transplantation provides an immune-tolerant platform for myoblast transplantation in dystrophic dogs.
... donor muscle derived cells into the fully chimeric cxmd recipient, G289, restored dystrophin expression to muscle fibers in muscle biopsies taken at five and ten weeks after injection (Figure ...
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Search | Preprints
... Demonstration of histochemical mosaic COX deficiency provides crucial evidence for a heteroplasmic mtDNA disease. The pathologist must take into account developmental, ageing-associated and secondary mitochondrial ...
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Year in review 2006: Critical Care – multiple organ failure, sepsis, and shock
... in muscle biopsies from septic patients, the severity of shock, organ failure, and outcome were directly related to the decreased activity of the mitochondrial complex I, decreased ATP levels, and ...
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The role of Coenzyme Q10 in statin-associated myopathy
... Muscle biopsies done in 4 patients with statin-associated myopathy demonstrated findings of intramuscular lipid, reduced cytochrome oxidase staining, and ragged red fibers, all of which resolved after ...
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Genomic signatures characterize leukocyte infiltration in myositis muscles
... tory muscle and the corresponding muscle fiber ...in muscle biopsies from myositis patients and normal ...(e.g., muscle cells) might contrib- ute significantly to ISG ...
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RNA metabolism in myotonic dystrophy: patient muscle shows decreased insulin receptor RNA and protein consistent with abnormal insulin resistance
... patient muscle biopsies, we recently showed that the DM kinase gene containing the expansion mutation is in- deed transcribed at levels similar to the normal ...
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GNE myopathy: from clinics and genetics to pathology and research strategies
... on muscle cultures and biopsies of GNE myopathy ...in biopsies by iTRAQ, 41 showed altered expression while the 2-DE analysis on biopsies revealed 26 differentially expressed ...versus ...
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Different atrophy-hypertrophy transcription pathways in muscles affected by severe and mild spinal muscular atrophy
... skeletal muscle tissue affected by spinal muscular atrophy with the significant analysis of very rare human muscle biopsies of the severe SMA type ...rat muscle undergoing atrophy following ...
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Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle full period in older men
... multiple muscle biopsies in healthy volunteers lead the authors (and their research ethics committee) to choose to employ independent groups as ...skeletal muscle net ...the muscle-full ...
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Clinical Reasoning: A 70-year-old man with walking difficulties
... lateralis muscle showed only fat. A muscle MRI was performed, after 2 nega- tive muscle biopsies, to select an appropriate muscle for a third muscle biopsy 3 and to investigate ...
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Myostatin and its precursor protein are increased in the skeletal muscle of patients with Type-II muscle fibre atrophy
... Type-II muscle fibres occurs in several clinical situations, including cachexia, muscle disuse, chronic glucocorticoid treatment, remote neoplasia, and sometimes as an aspect of ...the muscle-alanine ...
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PPAR-α agonism improves whole body and muscle mitochondrial fat oxidation, but does not alter intracellular fat concentrations in burn trauma children in a randomized controlled trial
... Decreased β-oxidation of FFA's and increased circulating concentrations of plasma FFA's are both likely related to insulin resistance. Offspring of type 2 diabetics who appear otherwise healthy have increased ...
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