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muscle loss

Early rehabilitation for volumetric muscle loss injury augments endogenous regenerative aspects of muscle strength and oxidative capacity

Early rehabilitation for volumetric muscle loss injury augments endogenous regenerative aspects of muscle strength and oxidative capacity

... volumetric muscle loss injury To investigate cellular mechanisms of the VML injury pathophysiology, additional cohorts of injured mice were allocated to VML with no repair or early rehabilitation (ROM or ...

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Coix seed oil ameliorates cancer cachexia by counteracting muscle loss and fat lipolysis

Coix seed oil ameliorates cancer cachexia by counteracting muscle loss and fat lipolysis

... Skeletal muscle wasting is the most prominent feature of cachexia in cancer ...in muscle tissue [6, ...Excessive loss of fat mass, another pathologic change usually accompanied with muscle ...

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Evaluation of adipose-derived stem cells for tissue-engineered muscle repair construct-mediated repair of a murine model of volumetric muscle loss injury

Evaluation of adipose-derived stem cells for tissue-engineered muscle repair construct-mediated repair of a murine model of volumetric muscle loss injury

... Volumetric muscle loss (VML) can occur from congenital defects, muscle wasting diseases, civilian or military injuries, and as a result of surgical removal of muscle tissue (eg, cancer), all ...

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Physical rehabilitation improves muscle function following volumetric muscle loss injury

Physical rehabilitation improves muscle function following volumetric muscle loss injury

... TA muscle to cause morphological ad- aptations as seen in this ...TA muscle is a non-load bearing muscle, therefore future work is needed to examine similar changes in load bearing ...

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Tacrolimus as an adjunct to autologous minced muscle grafts for the repair of a volumetric muscle loss injury

Tacrolimus as an adjunct to autologous minced muscle grafts for the repair of a volumetric muscle loss injury

... Herein we delivered systemic tacrolimus for 1 month following VML injury, during a period in which myogen- esis is expected to be increased. The target dosage of sys- temic tacrolimus was selected as it has been ...

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Evaluation of bone marrow mononuclear cells as an adjunct therapy to minced muscle graft for the treatment of volumetric muscle loss injuries

Evaluation of bone marrow mononuclear cells as an adjunct therapy to minced muscle graft for the treatment of volumetric muscle loss injuries

... prior observations [3]. This observation was supported on a transcriptional level, as no significant difference was mea- sured between the 50% MG and 50% MG with BMNC groups for the expression of the genes comprising our ...

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Strength Training for Arthritis Trial (START): design and rationale

Strength Training for Arthritis Trial (START): design and rationale

... Muscle loss and fat gain contribute to the disability, pain, and morbidity associated with knee OA [3], and thigh muscle weakness is an independent, modifiable risk factor ...

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Molecular Pathways of Protein Degradation in Muscular Dystrophies: Targets for Therapeutic Intervention.

Molecular Pathways of Protein Degradation in Muscular Dystrophies: Targets for Therapeutic Intervention.

... promote muscle regeneration would be those of choice for muscular ...prevent muscle loss induced by denervation or tumours in mice while clenbuterol inhibits the ubiquitin proteasome pathway and ...

166

DEVELOPMENT AND VALIDATION OF A LIGHT WEIGHT, ENERGY DENSE, READY TO EAT (RTE) BAR

DEVELOPMENT AND VALIDATION OF A LIGHT WEIGHT, ENERGY DENSE, READY TO EAT (RTE) BAR

... Stable energy balance and physical health are critical factors for certain high risk groups like soldiers and endurance athletes. Such individuals depend on their strength and stamina to do their jobs and often have ...

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The age related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans

The age related loss of skeletal muscle mass and function: measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans

... related muscle loss, remains ...losing muscle at twice the rate of younger people (Kortebein et ...of muscle mass loss in older ...recover muscle loss completely, despite ...

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MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment

MicroRNAs in cardiovascular disease: from pathogenesis to prevention and treatment

... a loss of miR-526b and miR-578 bind- ing exhibit increased blood ...miRNA loss-of-function SNPs in potential miRNA binding sites of tran- scripts encoding the bradykinin 2 (BDKRB2) and thromboxane A2 ...

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Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss  Effect on muscle glucose transport and glucose transporter GLUT4

Restoration of insulin responsiveness in skeletal muscle of morbidly obese patients after weight loss Effect on muscle glucose transport and glucose transporter GLUT4

... skeletal muscle glucose transport activity and levels of the glucose transporter protein ...weight loss of ...incubated muscle fibers was reduced by approximately 50% in obese patients at the time of ...

6

Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3

Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3

... that loss of MuRF1 and MuRF3 would lead to accumulation of undegraded ...DKO muscle but are clearly not sufficient for complete MHC degrada- ...the loss of the Z-disc (41), a finding analogous to our ...

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Anorexia–cachexia syndrome-like hypothalamic neuroendocrine dysfunction in a patient with a papillary craniopharyngioma

Anorexia–cachexia syndrome-like hypothalamic neuroendocrine dysfunction in a patient with a papillary craniopharyngioma

... A 48-year-old man was admitted for evaluation and management of acute adrenal insufficiency, myxedema and diabetes insipidus. His family history reveals type 2 diabetes and hypertension; his father had pulmonary ...

7

The NK 2 class homeodomain factor CEH 51 and the T box factor TBX 35 have
overlapping function in C  elegans mesoderm development

The NK 2 class homeodomain factor CEH 51 and the T box factor TBX 35 have overlapping function in C elegans mesoderm development

... We have identified a new regulator, CEH-51, in MS specification. Our results suggest that TBX-35 and CEH-51 could participate in a ‘feed-forward’ regulatory cascade (Lee et al., 2002), in which TBX- 35 activates ceh-51, ...

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Regenerative defect in vastus lateralis muscle of patients with chronic obstructive pulmonary disease

Regenerative defect in vastus lateralis muscle of patients with chronic obstructive pulmonary disease

... skeletal muscle genes ...skeletal muscle cells and it has been suggested that they can counterweigh their own individual ...skeletal muscle development ...

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Is dynamometry able to infer the risk of muscle mass loss in patients with COPD?

Is dynamometry able to infer the risk of muscle mass loss in patients with COPD?

... Patients’ anthropometric characteristics, their values of upper and lower limbs muscle strength, and the comparison between HLM and LLM are shown in Table 1. Twenty-five patients (19 men and six women) had ...

5

The contributions of fibre atrophy, fibre loss, in situ specific force and voluntary activation to weakness in sarcopenia

The contributions of fibre atrophy, fibre loss, in situ specific force and voluntary activation to weakness in sarcopenia

... of muscle quality that included an accurate (CT) measurement of muscle size showed around 5% loss of thigh muscle CSA and 16% decrease in MVC force over 5 years in older men and women ...

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Neutrophil mediated smooth muscle cell loss precedes allograft vasculopathy

Neutrophil mediated smooth muscle cell loss precedes allograft vasculopathy

... SMC loss in the grafts after 20 min cold ischemia and profound medial SMC loss (> 90% vs native aorta) at 1d post-transplant (Fig ...SMC loss at 1d ...

11

Effects of weight loss and exercise on trunk muscle composition in older women

Effects of weight loss and exercise on trunk muscle composition in older women

... abdominal muscle had the greatest fatty infiltration, followed by the lateral abdominal muscle and erector spinae, in these overweight and obese women, suggesting that obesity contributes to the increased ...

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