Muscle protein degradation
Understanding neuromuscular weakness of acute organophosphate poisoning: the significance of metabolic energy, muscle protein degradation and amino acids.
... to muscle weakness is the inhibition of AChE at the neuromuscular ...understand muscle weakness pertaining to the course and outcome of OPP there is need to study muscle ...
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Leucine Oxidation and Protein Turnover in Clofibrate induced Muscle Protein Degradation in Rats
... Treatment of hyperlipidemia with clofibrate may result in development of a muscular syndrome. Our previous investigation (1979. J. Clin. Invest.64: 405.) showed that chronic administration of clofibrate to rats causes ...
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Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate dependent pathway involving ubiquitin and proteasomes
... body protein due mainly to accelerated protein breakdown in ...measured protein degradation in incubated epitrochlearis muscles from acidotic (NH4Cl-treated) and pair-fed rats under conditions ...
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Muscle wasting in insulinopenic rats results from activation of the ATP dependent, ubiquitin proteasome proteolytic pathway by a mechanism including gene transcription
... of muscle, liver, and adi- pose ...of muscle mass with insulinopenia is related to accelerated pro- tein ...of protein degradation is increased in the perfused hind- quarter muscles of ...
7
Securitizing British India: A New Framework of Analysis for the First Anglo Afghan War
... consumption, protein synthesis decreases by 15 to 30%, resulting in a net catabolic ...stimulate protein synthesis (Norton & Layman, ...net muscle protein balance (Alvestrand et ...2009). ...
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Systemic response to thermal injury in rats Accelerated protein degradation and altered glucose utilization in muscle
... increased muscle protein degradation (PD) from 140 +/- 5 to 225 +/- 5 nmol tyrosine/g per h, but did not alter protein ...synthesis. Muscle lactate release was increased greater than ...
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Impaired actions of insulin like growth factor 1 on protein Synthesis and degradation in skeletal muscle of rats with chronic renal failure Evidence for a postreceptor defect
... skeletal muscle protein degradation, i.e., the sum of both protein synthetic and degradative rates; both increased protein degradation and/or reduced protein synthesis ...
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Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid dependent mechanism
... day, muscle protein degradation was increased if the muscles were simply incubated in acidified ...stimulates muscle proteolysis but does not affect protein ...
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Responsiveness of muscle protein synthesis to growth hormone administration in HIV infected individuals declines with severity of disease
... of muscle protein degradation, assessed from 3-MH excretion, by an average of 16% across all the groups, with the largest stimu- lation, 2868%, in the control and HIV1 groups, and much smaller, ...
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Regulation of protein degradation pathways by amino acids and insulin in skeletal muscle of neonatal pigs
... continual degradation and synthesis of protein, i.e., protein turnover, is crucial for homeostatic functions of normal cells ...of muscle protein degradation ...the ...
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Mechanisms of postprandial protein accretion in human skeletal muscle Insight from leucine and phenylalanine forearm kinetics
... forearm protein degradation might have been mediated by hyperinsulinemia, by hyperaminoaci- demia, or by other ...of protein degradation in muscle (47, ...inhibit muscle ...
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Short-term, high-fat diet accelerates disuse atrophy and protein degradation in a muscle-specific manner in mice
... of muscle protein degradation, and loss of skeletal muscle ...induce muscle at- rophy ...basal muscle protein metabolism [14], but dem- onstrate whole-body insulin ...
11
Functional phosphatome requirement for protein homeostasis, networked mitochondria, and sarcomere structure in C elegans muscle
... autophagic protein degradation is the type of protein degradation most commonly triggered in response to knockdown of any individual kinase or phos- phatase, we have found that functional ...
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Insulin alleviates degradation of skeletal muscle protein by inhibiting the ubiquitin-proteasome system in septic rats
... cardiac muscle protein catabolism in diabetes ...accelerates muscle protein degradation by activation of the Ub-proteasome ...associated protein, ...
8
Mechanisms for defects in muscle protein metabolism in rats with chronic uremia Influence of metabolic acidosis
... abnormal muscle protein ...stimulates muscle protein degradation by a glucocorticoid-dependent mechanism, we assessed the contribution of acidosis to changes in muscle ...
6
Selective STAT Protein Degradation Induced by Paramyxoviruses Requires both STAT1 and STAT2 but Is Independent of Alpha/Beta Interferon Signal Transduction
... STAT1 protein for proteolytic ...virus-encoded protein called V (11, 12, ...inducing degradation of STAT2 and not STAT1 (40, ...V protein from a cDNA clone is sufficient to abolish IFN-respon- ...
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Important roles of C terminal residues in degradation of capsid protein of classical swine fever virus
... C-EGFP protein expressed at a low level and decreased over time, we assume that C-EGFP protein might be degraded after ...Since degradation of intracellular proteins are generally mediated by 26S ...
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Regulation of Apolipoprotein E Trafficking by Hepatitis C Virus-Induced Autophagy
... ApoE is important for the production of infectious HCV particles. Thus, the observation that ApoE was degraded by HCV-induced autophagy was curious. To address this question, we studied the possible role of autophagy in ...
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Branched-chain amino acids and muscle protein synthesis in humans: myth or reality?
... of muscle protein ...of muscle protein synthesis in the post-absorptive state in response to BCAAs alone is the difference between muscle protein breakdown and muscle ...
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Biochemical abnormalities in erythrocytes from patients with Duchenne muscular dystrophy and multiple sclerosis
... sho r t e r and wid e r m y o t u b u l e s in his DMD m u s c l e t i s s u e c u l t u r e . N u m b e r s of n u c le i in the m y o t u b u l e s in the c u l t u r e d DMD m u s c l e s were fou n d to be i n c r e ...
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