Myc and apoptosis
Autophagy inhibition enhances therapy induced apoptosis in a Myc induced model of lymphoma
... ing Myc/p53ER TAM tumor growth, based on the accumulation of autophagic vesicles when their clearance by lysosomes is inhibited by ...induces apoptosis, autophagy serves to protect against cell ...
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ROCK inhibitor reduces Myc-induced apoptosis and mediates immortalization of human keratinocytes
... The Myc/Max/Mad network plays a critical role in cell proliferation, differentiation and apoptosis and c-Myc is overexpressed in many cancers, including HPV-positive cervical cancer cell ...high ...
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Role of NF-κB and Myc Proteins in Apoptosis Induced by Hepatitis B Virus HBx Protein
... to apoptosis by proapoptotic stimuli, including tumor necrosis factor alpha (TNF- ␣ ) and ...of Myc protein family members in certain settings, and Myc can sensitize cells to killing by TNF- ␣ ...
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IBTK contributes to B-cell lymphomagenesis in Eμ-myc transgenic mice conferring resistance to apoptosis
... of Myc-driven ...increased apoptosis, as measured by Annexin V binding, Caspase 3/7 cleavage assays and cell cycle profile ...and myc expression and demonstrated a Myc-dependent regulation of ...
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High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle
... whether Myc and p27 are coexpressed in CLL and whether Myc can compensate the reported high p27 ...and Myc in tumoral peripheral CLL cells and their correlation with the clinical features of the ...
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The Role of Myc and the miR 17~92 Cluster in Histone Deacetylase Inhibitor Induced Apoptosis of Solid Tumors
... that Myc plays in this process in solid tumors, we compared the effect of two HDAC inhibitors, SAHA and LAQ824, on the proliferation of solid tumor cell lines expressing high versus low levels of ...of Myc ...
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Original Article Effect of oxidative stress on neuronic apoptosis and c-myc expression after cerebral hemorrhage
... for mediating inflammatory factor, cytokine, chemotactic factor transcriptional levels such as IL-8 and IL-6, thus playing an important role in cell inflammation and apoptosis. Previous study showed the ...
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MicroRNA 155 controls affinity based selection by protecting c MYC+ B cells from apoptosis
... from apoptosis Rinako Nakagawa, … , Robert Brink, Elena Vigorito J Clin ...from apoptosis, allowing clonal expansion of this population, providing an explanation as to why Mir155 deletion impairs affinity ...
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Apparent uncoupling of oncogenicity from fibroblast transformation and apoptosis in a mutant myc gene transduced by feline leukemia virus.
... 50-kDa Myc protein at exceptionally high levels, while the endogenous c-myc gene was not detectably ...mutant Myc product expresses an oncogenic function in T ...by apoptosis when cultured ...
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Original Article MPEG-SOD inhibits cerebral hemorrhage induced neural cell apoptosis and c-myc upregulation
... cell apoptosis and c-myc protein ...cell apoptosis, the expression level of c-myc protein, and the cor- relationship between them were ...cell apoptosis rates in test group were ...
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Abnormal expression of apoptosis-related genes in haematological malignancies: Overexpression of MYC is poor prognostic sign in mantle cell lymphoma
... of apoptosis-related genes BCL2, BAX, BCL2L1, BCL2A1, MCL1, DAPK1 and MYC was studied by quantitative real-time polymerase chain reaction on total RNA samples from patients with acute lympho- blastic ...
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Decoding c-Myc networks of cell cycle and apoptosis regulated genes in a transgenic mouse model of papillary lung adenocarcinomas
... ABSTRACT The c-Myc gene codes for a basic-helix-loop-helix-leucine zipper transcription factor protein and is reported to be frequently over-expressed in human cancers. Given that c-Myc plays an essential ...
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CELLFOOD™ induces apoptosis in human mesothelioma and colorectal cancer cells by modulating p53, c-myc and pAkt signaling pathways
... and apoptosis induction [48]. c-Myc expression is low in quiescent normal cells whereas it is elevated in a broad range of human cancers, such as the malignant pleural mesotheli- oma, indicating its key ...
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Roles of MYC-targeting long non-coding RNA MINCR in cell cycle regulation and apoptosis in non-small cell lung Cancer
... Methods: Expression levels of MINCR was first identified using The Cancer Genome Atlas (TCGA), further confirmed with specimens from 29 NSCLC patients and three cell lines using qRT-PCR. Overexpression and knockdown of ...
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The BET bromodomain inhibitor, JQ1, facilitates c-FLIP degradation and enhances TRAIL-induced apoptosis independent of BRD4 and c-Myc inhibition
... of apoptosis, have not been fully ...induced apoptosis; this enhanced apoptosis-inducing activity could be abolished by enforced expression of ectopic FLIP L or FLIP S ...induced apoptosis, ...
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Cytoplasmic calcium increase via fusion with inactivated Sendai virus induces apoptosis in human multiple myeloma cells by downregulation of c-Myc oncogene
... HVJ-E, apoptosis, Ca 2+ , c-Myc, multiple myeloma Received: October 26, 2015 Accepted: April 16, 2016 Published: April 29, 2016 AbstrAct Because the emergence of drug resistance is a major limitation of ...
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Oncolytic Activity of Vesicular Stomatitis Virus Is Effective against Tumors Exhibiting Aberrant p53, Ras, or Myc Function and Involves the Induction of Apoptosis
... Received 3 November 2000/Accepted 9 January 2001 We have recently shown that vesicular stomatitis virus (VSV) exhibits potent oncolytic activity both in vitro and in vivo (S. Balachandran and G. N. Barber, IUBMB Life ...
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<p>Cobalt Chloride Induced Apoptosis by Inhibiting GPC3 Expression via the HIF-1α/c-Myc Axis in HepG2 Cells</p>
... Although the pathogenesis of HCC is complicated, an array of critical genes or proteins have been identi fi ed as being involved in HCC tumour progression. Recent studies have shown that the level of GPC3 is drastically ...
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Original Article miR-145 inhibits tumor proliferation and invasion and induces apoptosis in gastric cancer by targeting c-Myc
... and apoptosis of gastric cancer, and its relationship with the target gene ...and apoptosis of SGC-7901 cells were examined by colony formation assay, transwell chamber invasion assay and flow cytometry ...
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MYC amplifications in myeloma cell lines: correlation with MYC-inhibitor efficacy
... molecule MYC inhibitor 10058-F4 induces apoptosis in myeloma cell lines and primary ...downregulated MYC protein and mRNA in a dose- dependent manner in myeloma cells (Supplemenatry Figure ...
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