MYC and cell growth
A Role for the Serine/Arginine-Rich (SR) Protein B52/SRSF6 in Cell Growth and Myc Expression in Drosophila
... of myc overexpression induced by B52 over- expression, especially in the salivary gland (Figure 4C), raises the question of how B52 expression level modulates myc tran- ...in cell growth and ...
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Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay dependent manner
... Consistent with the predicted role of FIR in c-myc repression, FIR mutants lacking the N-terminal c-myc repression domain are found frequently in human primary colorectal cancer tissues, which suggests that ...
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MiR-145 inhibits oral squamous cell carcinoma (OSCC) cell growth by targeting c-Myc and Cdk6
... significant growth-suppressing effect by inhibiting cell proliferation and colony formation in the present ...duces cell cycle arrest and apoptosis, further suggesting its tumor suppressor ...of ...
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Myc confers androgen independent prostate cancer cell growth
... cancer cell lines (PC-3 and DU-145) (Figure ...overcome growth arrest induced by AR antagonist treat- ment as it did in LNCaP cells (Figure ...similar growth characteristics in the presence or ...
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CUDR promotes liver cancer stem cell growth through upregulating TERT and C-Myc
... dephosporylation of the 3` phosphate of the inositol ring in PIP 3 , resulting in the biphosphate product PIP 2 (PtdIns(4,5) P2). This dephosphorylation is important because it results in inhibition of the AKT signaling ...
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The knockdown of c-myc expression by RNAi inhibits cell proliferation in human colon cancer HT-29 cells in vitro and in vivo
... the myc proto-oncogene family, c-, L-, and N-myc, are thought to be central regulators of cell growth, and deregulated myc expression is associated with many cancers, including colon ...
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Synthetic regulatory RNAs selectively suppress the progression of bladder cancer
... and MYC expression ...knockdown MYC expression. The qRT-PCR results showed that si-MYC, but not si-NC, can dramatically de- crease the expression of MYC in T24 and 5637 ...of MYC in si- ...
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Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors
... lymphomas. MYC and BCL2 translocations drive proliferation and prevent apoptosis in ...that MYC overexpression correlated with inferior event- free survival in DLBCL ...[15]. MYC acts as a proto- ...
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Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation
... on MYC targeting, because of the opposite roles of MYC and TP53 in the regulation of ...p21. MYC hampers p21 functions in several contexts, for instance by repressing its transcription [37, 38], ...
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<p>MicroRNAs Targeting MYC Expression: Trace of Hope for Pancreatic Cancer Therapy. A Systematic Review</p>
... as cell cycle, differentiation, cell growth, cell adhesion, angiogenesis, chromosomal instability, and cell ...schematically MYC-regulated activities in tumorigenesis and ...
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“Picolog,” a Synthetically-Available Bryostatin Analog, Inhibits Growth of MYC-Induced Lymphoma In Vivo Brian A. DeChristopher 1,* , Alice C. Fan 2,* , Dean W. Felsher 2, Paul A. Wender1
... not cell cycle arrest, was induced compared with untreated control (p = ...if growth inhibitory activity of picolog was due to PKC activation, the broad spectrum PKC inhibitor Go6983 was administered alone ...
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Cell density and paradoxical transcriptional properties of c Myc and Max in cultured mouse fibroblasts
... in cell growth. c-Myc has been reported to both activate and repress transcription in transient transfection experiments using reporter constructs bearing multiple copies of the c-Myc binding ...
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PubMedCentral-PMC4728445.pdf
... during cell growth implies that DCAF1 may control c-Myc expression through factors important for transcription and/or epigenetics, for example, TET (Ten-eleven translocation methylcytosine ...
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PDZK1 Is a Novel Factor in Breast Cancer That Is Indirectly Regulated by Estrogen through IGF-1R and Promotes Estrogen-Mediated Growth
... cancer cell lines were used to conduct the ...insulinlike growth factor 1 receptor (IGF-1R) expression and ...ER-dependent growth and reduced c-Myc expression, whereas ectopic expression of ...
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Human CD30+ B cells represent a unique subset related to Hodgkin lymphoma cells
... Moreover, MYC activity in HRS cells is at least partly mediated through STAT3/5 activation via induction of the AP-1 family member BATF3, which directly induces MYC transcription in HRS cells ...B ...
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CD19 is a major B cell receptor–independent activator of MYC driven B lymphomagenesis
... Total cell lysates were prepared, and Western blotting was performed as described previously ...3574, Cell Signaling Technology), anti-PAN AKT (no. 4691, Cell Signaling Technology), anti–phospho-AKT ...
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RNAi silencing of c-Myc inhibits cell migration, invasion, and proliferation in HepG2 human hepatocellular carcinoma cell line: c-Myc silencing in hepatocellular carcinoma cell
... levels of c-Myc were decreased as early as 24 hours after transfection and remained at low levels until 8 days after transfection (Figure 2). Our obtained inhibition rate by siRNA seemed to be higher than that in ...
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Investigating the Role of Retinoblastoma Protein and Transforming Growth Factor-Beta in Growth Inhibition
... To examine our proposed models, we can use shRNAs against DNMT1 and MBD2 to knockdown their expression and examine whether depletion of these proteins compromise TGF-β mediated growth arrest. In addition, we can ...
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MYC is a major determinant of mitotic cell fate
... while cell death signals become stronger, cyclin B1 levels slowly fall due to incomplete penetrance of SAC-mediated APC/C inhibi- tion (Brito and Rieder, ...the cell is dictated by which threshold is ...
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The c-myc Locus Is a Common Integration Site in Type B Retrovirus-Induced T-Cell Lymphomas
... As in leukemias induced by other retroviruses, c-myc ap- pears to be activated two- to sixfold by an enhancer insertion mechanism in most TBLV-induced T-cell lymphomas, and this conclusion is supported by ...
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