Myc and proliferation
PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferation
... NM23 nucleoside diphosphate kinase 2 (NME2). PIWIL2 promotes c-Myc transcription by interacting with and facilitating NME2 to bind to G4-motif region within c-Myc promoter. Interestingly, in a ...
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CSIG promotes hepatocellular carcinoma proliferation by activating c-MYC expression
... CSIG protein was overexpressed in 86.4% of the human HCC cancerous tissues as compared with matched surrounding tissues, and its protein expression was greater in HCC cells than the non-transformed hepatic cell line L02. ...
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CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation
... the proliferation of human leukemia and lymphoma cell ...and MYC‑driven transcription, causing the accumulation of cells in the G0/G1 phase of the cell ...
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Expression of c-myc is not critical for cell proliferation in established human leukemia lines
... c- myc is not crit- ical for cell proliferation in the established leukemia lines ...c- myc, was responsible for the observed biological activity, leading to apoptosis and cell cycle ar- rest by a ...
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High OGT activity is essential for MYC-driven proliferation of prostate cancer cells
... promote proliferation of prostate cancer ...for MYC-related ...and MYC binding ...and MYC ChIP-mass spectrometry, we identify host cell factor 1 (HCF-1) as an interaction partner of ...
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The Evi5 oncogene promotes laryngeal cancer cells proliferation by stabilizing c-Myc protein
... Thus, these data suggesting Evi5 regulates c-Myc protein stability. Evi5 interacts with c‑myc to prevent its degradation To further test this possibility, we compared the half- life of c-Myc protein ...
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Pim1 promotes cell proliferation and regulates glycolysis via interaction with MYC in ovarian cancer
... on MYC, a pivotal gene in glycolysis, and observed that Pim1-mediated phosphorylation of c-Myc activated the expression of glycolysis-associated key genes such as PGK1 and ...
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The long non-coding RNA PARROT is an upstream regulator of c-Myc and affects proliferation and translation
... Keywords: MYC, long ncRNA Received: April 13, 2016 Accepted: April 16, 2016 Published: April 25, 2016 AbstrAct Long non-coding RNAs are important regulators of gene expression and signaling ...with ...
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Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c myc antisense oligodeoxynucleotides
... VSMC proliferation. We have examined the effect on VSMC proliferation of blocking expression of the c-myc proto-oncogene with antisense oligodeoxynucleotides, both in vitro and in a rat carotid ...
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N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation
... the Myc family of helix-loop-helix transcription factors ...cell proliferation, the present study carefully examined two Mg 2+ -transporting channel kinases, TRPM7 and TRPM6, in neuroblastoma ...
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miRNA-320a inhibits tumor proliferation and invasion by targeting c-Myc in human hepatocellular carcinoma
... scale bar =50 μm. Data are presented as the mean ± standard deviation (n=3). results were obtained in three replicates. **P,0.01. Abbreviations: mir-320a, microrna-320a; nc, negative control; si or sirna, small ...
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c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland
... size of the polysomes in its absence; however, some selec- tivity was also uncovered. While mRNA transcripts of milk proteins (Lalba and Csn2) and enzymes important for milk production (Fads2, Scd2, Elovl1, and Aldo3) ...
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RNAi silencing of c-Myc inhibits cell migration, invasion, and proliferation in HepG2 human hepatocellular carcinoma cell line: c-Myc silencing in hepatocellular carcinoma cell
... and proliferation of HCC cells. Although we obtained comparable c-Myc inhibition with plasmid expressing antisense c-Myc mRNA, the advantages provided by siRNA technology should be relevant for in ...
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Decrease expression of microRNA-744 promotes cell proliferation by targeting c-Myc in human hepatocellular carcinoma
... Our findings demonstrated that miR-744 was frequently down-regulated in HCC cell lines and clinical samples. Our data demonstrated for the first time that restoration of miR-744 significantly inhibited HCC cells ...
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Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells
... the proliferation character- istics of MCS for clinical ...good proliferation rates of the MSC but also caused a detrimental shift to- wards a hypertrophic collagen phenotype and cartilage degeneration ...
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Bortezomib inhibits Burkitt’s lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression
... CONCLUSIONS We showed that several aspects of proteins can be regulated by bortezomib, in particular, it downregulated the expression of sumoylated hnRNP K and c-Myc in human Burkitt’s lymphoma cells. Sumoylated ...
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<p>Repression of PCGF1 Decreases the Proliferation of Glioblastoma Cells in Association with Inactivation of c-Myc Signaling Pathway</p>
... tumor proliferation pathways, including PI3K/AKT signal- ing, which plays a key role in the cell proliferation, apoptosis, metabolism, motility, and angiogenesis in glioblastoma ...promote ...
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Association of castration-dependent early induction of c-myc expression with a cell proliferation of the ventral prostate gland in rat
... Abstract The protooncogene c-myc is known to be associ- ated with both cell proliferation and apoptosis. The possible cellular affects of castration on the ventral prostate gland of rat as well as the ...
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Analysis of secretome changes uncovers an autocrine/paracrine component in the ability of c -Myc to modulate cell proliferation and motility
... Abstract: Proteins secreted by cancer cells are a major component of tumor microenvironment. How- ever, little is known on the impact of single oncogenic lesions on the expression of secreted proteins at early stages of ...
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LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis
... mechanisms between LINC01123 and c-Myc. Results: Three hundred sixty-four differentially expressed genes were identified in RNA-seq assay, and LINC01123 was one of the most overexpressed lncRNAs. Further ...
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