Myc Oncogene
Generation and characterization of a recombinant Moloney murine leukemia virus containing the v-myc oncogene of avian MC29 virus: in vitro transformation and in vivo pathogenesis.
... For instance, the avian retrovirus MC29, which carries the v-myc oncogene, induces myelocytomatosis a myeloid neoplasm in chickens, whereas Rous sarcoma virus carrying the v-src oncogene[r] ...
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Lipid nanoparticles that deliver IL-12 messenger RNA suppress tumorigenesis in MYC oncogene-driven hepatocellular carcinoma
... of MYC oncogene-driven ...of MYC-induced HCC transgenic mice in comparison to control ...transgenic MYC levels confirming that its therapeutic efficacy was not related to the downregulation of ...
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Sequential bcl 2 and c myc oncogene rearrangements associated with the clinical transformation of non Hodgkin's lymphoma
... chromosomal breakpoint at that site. The presence of the c-myc rearrangement in the high- grade tumor suggest a role for c-myc in the clonal evolution of the low-grade tumor into a more aggressive lymphoma. ...
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Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics
... and a representative of cationic porphyrins, TMPyP4 (Fig. 5) [87] is of special concern. Based on microcalo- rimetric (ITC, isothermal titration calorimitry, and DSC, differential scanning calorimetry), spectrometric ...
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Avian acute leukemia virus OK 10: analysis of its myc oncogene by molecular cloning.
... 347-354 0022-538X/83/050347-08$02.00/0 Copyright © 1983, American Society for Microbiology Avian Acute Leukemia Virus OK 10: Analysis of Its Oncogene by Molecular Cloning myc SUSAN PFEIF[r] ...
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Molecular cloning of proviral DNA and structural analysis of the transduced myc oncogene of avian oncovirus CMII.
... In the present communication, we report the molecular cloning of CMII proviral DNA, we compare its genetic structure and particularly its transforming gene with those of the other member[r] ...
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Cytoplasmic calcium increase via fusion with inactivated Sendai virus induces apoptosis in human multiple myeloma cells by downregulation of c-Myc oncogene
... In this study, we demonstrated that in contrast to MM1S and NCI-H929 cells, U266 cells showed a lack of response to HVJ-E (Figure 1A, Supplementary Figure 1D). We considered that this differential susceptibility to HVJ-E ...
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The Role of Corrective Gene Therapy Targeting the C-myc Oncogene in Melanoma
... against myc oncoproteins (Cambridge Research Biochemicals Ltd.). Both N-myc and L- myc are highly tissue specific (Garte, 1993) and the oncoprotein products o f these genes have not been described in ...
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Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta
... Regardless of the provoking stimuli, efforts to target activated microglia for the treatment of certain neuro- degenerative diseases include pharmacological re- polarization to the more anti-inflammatory phenotype [2, ...
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Oncogene withdrawal engages the immune system to induce sustained cancer regression
... which oncogene “withdrawal” results in immune activation (Figure 1, ...of MYC-induced T cell Acute Lymphoblastic Leukemia (T-ALL), the tumor cells undergo proliferative arrest and death within 2 days of ...
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Regulation of C myc expression during growth and differentiation of normal and leukemic human myeloid progenitor cells
... C-myc proto-oncogene transcripts from serially harvested, colony-stimulating activity (CSA)- stimulated, normal progenitor-enriched human bone marrow cells were compared to those of the promyelocytic ...
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Oncogenes in immune cells as potential therapeutic targets
... c-Myc oncogene can upregulate the expression of NK cell-activating ligands in cancer cells, making them targets of NK cell cytotoxicity: there is evidence that NKG2D ligands are induced on spontaneously ...
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The Evi5 oncogene promotes laryngeal cancer cells proliferation by stabilizing c-Myc protein
... Results: Here, we show that Evi5 controls LSCC tumorigenesis via the stabilization of c‑MYC oncogene. CRISPR‑medi‑ ated knockout (KO) of Evi5 decreased the proliferation and decreased colony formation ...
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Changes in the phenotype of human small cell lung cancer cell lines after transfection and expression of the c myc proto oncogene
... Small cell lung cancer growing in cell culture possesses biologic properties that allow classification into two categories: classic and variant. Compared with classic small cell lung cancer cell lines, variant lines have ...
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DNA Methylation Mediated Downregulation of miR-449c Controls Osteosarcoma Cell Cycle Progression by Directly Targeting Oncogene c-Myc
... c-Myc functions as a transcription factor and plays multiple roles in tumorigenesis, such as cell cycle progression and apoptosis; moreover, c-Myc is usually overexpressed in different cancer types, such as ...
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The therapeutic potential of bone marrow mesenchymal stem cells in premature ovarian failure
... cell proliferation to increase steroid hormone secretion, and aromatase (Cyp19) stimulation by follicle-stimulating hor- mone (FSH) in ovarian granulosa cells depends on the acti- vation of the IGF-1 receptor-signaling ...
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Immune checkpoint inhibitor treatment in patients with oncogene-addicted non-small cell lung cancer (NSCLC): summary of a multidisciplinary round-table discussion
... the oncogene on the activity of the inflamma- tory tumour microenvironment, the combination of TKI with ICI is of potential clinical ...with oncogene-addicted NSCLC based on the so far available data from ...
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Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis
... of library tags was performed by Tufts University Core Facility and UNMC using an Illumina Genome Analyzer II. The resulting 18-bp sequence tags were aligned with the mouse genome (mm9) using the short read sequence ...
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PVT1 MYC expression through real time PCR in plasma cells purified from 59
... and MYC in MM cells compared to that in normal plasma cells is consistent with previous studies ...increased MYC expression compared to normal tissues and are associated with a poor prognosis ...and ...
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Invasion of Host Cells by JC Virus Identifies a Novel Role for Caveolae in Endosomal Sorting of Noncaveolar Ligands
... Confocal microscopy/constructs. Green fluorescent protein (GFP)-Rab constructs GFP-Rab5, GFP-Rab7, GFP-Rab11, GFP-Rab5-S34N, GFP-Rab7- T22N, and GFP-Rab11-S25N were kind gifts of Stephen Furguson (Robart Research ...
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