myelin proteins
Original Article Comparing the effect of neurotrophic factor induced MSCs (BMSC and DPSC) on the expression of myelin proteins Nogo-A and OMgp in a glaucoma rat model
... of degenerative diseases of CNS [16]. The lim- ited therapeutic strategies to cure glaucoma has largely expanded the use of MSCs to devel- op regenerative and reparative treatments. MSCs are considered to be potential ...
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Schaefer, Karin (2010): Characterization of two novel myelin proteins. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... the myelin sheath, Schwann cells and oligodendrocytes, has not been analyzed in detail in this transgenic ...monitoring myelin maintenance and markers of ER stress might reveal characteristic features of ...
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Receptor-mediated phagocytosis of myelin by macrophages and microglia
... opsonising myelin with either antibodies against myelin proteins or non-related antibodies, and examining its effect on uptake by both MG and M0 (Sommer et al, 1992, Smith et al, 1987, Trotter et al, ...
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Proteomics of the corpus callosum to identify novel factors involved in hypomyelinated Niemann-Pick Type C disease mice
... downregulated proteins, twelve were anno- tated as myelin proteins, in which some are essential for the axonal integrity and ...inhibit myelin formation but causes widespread axonal swelling ...
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Molecular Mimicry Revisited: Gut Bacteria and Multiple Sclerosis
... brain, myelin, one of the myelin proteins, or encephalitogenic peptides in an appropriate adjuvant are injected into test ...myelin proteins. Most of the encephalitogenic regions found ...
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Myelin-phagocytosing macrophages modulate autoreactive T cell proliferation
... with myelin. Restimulated popliteal lymph nodes of myelin- treated animals display reduced OVA-induced prolifera- tion compared to lymphocytes derived from untreated OVA-immunized ...of myelin ...
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Concepts of Myelin and Myelination in Neuroradiology
... in myelin (50). The precise component of myelin that is at- tacked in cases of MS is not known, but it is likely that different viral antigens may cross-react with many different ...with myelin ...
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Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation
... of myelin proteins showed no significant differences between the three groups, suggesting that myelination is not overtly impaired in Polr3a KI/KI and KI/KO ...
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Reactivity to myelin antigens in multiple sclerosis Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein
... major myelin proteins, myelin basic protein (MBP) and proteolipid protein (PLP), are likely to be of importance in the course of multiple sclerosis (MS), cell-mediated autoimmune responses to other ...
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Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss
... of myelin-specific proteins, which are critical for myelin structure, assembly and in- tegrity, because they regulate the molecular organization within the myelin sheath ...oligodendroglial ...
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Autoimmune-induced preferential depletion of myelin-associated glycoprotein (MAG) is genetically regulated in relapsing EAE (B6 × SJL) F1 mice
... of myelin asso- ciated glycoprotein (MAG), which is a type I transmembrane glycoprotein positioned at periaxonal regions in the inner most loop of the oligodendrocyte cell ...in myelin and axonal ...
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Systemic TLR2 tolerance enhances central nervous system remyelination
... Similarly, myelin parameters did not differ between WT and TLR2 − / − mice fed normal chow for the entire 5 and 2 week pe- riods ...and myelin thickness when com- pared to WT mice ...enhanced myelin ...
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The spleen may be an important target of stem cell therapy for stroke
... MBP: Myelin basic protein; MCP: Monocyte chemoattractant protein; MMP: Matrix metalloproteinase; MOG: Myelin oligodendrocyte glycoprotein; MSCs: Mesenchymal stem cells; MultiStem: The MAPC clinical product; ...
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Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases
... of myelin-related gene ...of myelin-related systems in mouse and human brain iron dyshomeostasis, with expanded literature and array data mining revealing 17 new myelin-related genes showing altered ...
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Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia
... The use of selective channel blockers showed that CRAC was important for phagocytosis under all activa- tion conditions examined, while myelin phagocytosis and ROS production by activated microglia were both ...
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Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia
... For quantitative real-time PCR (QPCR), complementary DNA was synthesized from 1 μg total RNA with an oligo- nucleotide deoxythymidine primer and Superscript First- Strand synthesis system (Invitrogen). QPCR was per- ...
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Neonatal hypothyroidism affects the timely expression of myelin associated glycoprotein in the rat brain
... on myelin gene expression, we have studied the effect of hypothyroidism on the steady state levels of myelin-associated glycoprotein (MAG) and its mRNA in rat brain during the first postnatal ...
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The molecular genetics of myelin genes
... PMP-22 is a transmembrane protein that is expressed in Schwann cells and is present in all myelin sheaths of the PNS (Snipes et al. 1992). Expression in the CNS has been detected at a very low level, but it is ...
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Molecular genetic analysis of the mldr mouse: a spontaneous revertant at the mld locus containing a recombinant myelin basic protein gene.
... THIEU, 1989 Expression of the downstream copy of myelin basic protein gene in myelin deficient mutant mice. MAT- THIEU, 1990 Post-transcriptional events are responsible [r] ...
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Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes
... whereas myelin, Schwann cells, oligodendrocytes and astrocytes express CD47 without SIRP a ...and myelin by anti-MBP mAb (red); overlap between the two is yellow. Myelin is present in the cytoplasm ...
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