Myoblast fusion
A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk like in zebrafish myoblast fusion
... of myoblast fusion is conserved between Drosophila and vertebrates, we identified homologues of DOCK180 in the zebrafish and used morpholinos to block their ...compromised myoblast fusion in ...
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The actin nucleator WASp is required for myoblast fusion during adult Drosophila myogenesis
... Although Wsp performs essential roles throughout Drosophila development, flies lacking zygotic Wsp function survive until late pupal/early adult stages because maternally contributed Wsp gene products are sufficient for ...
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SCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusion
... of fusion? and (2) what are the contributions of the identified proteins to this cytoskeleton remodeling at the fusion site? Here we apply novel methods in Drosophila to investigate the mechanisms ...
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Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma
... the fusion oncoprotein PAX-FOXO1, but the underlying RMS pathogenet- ic mechanisms that impede differentiation and promote neoplastic transformation remain ...the myoblast fusion gene rolling pebbles ...
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Asymmetric Mbc, active Rac1 and F actin foci in the fusion competent myoblasts during myoblast fusion in Drosophila
... Myoblast fusion is an intricate process that is initiated by cell recognition and adhesion, and culminates in cell membrane breakdown and formation of multinucleate ...and fusion-competent myoblasts ...
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An RNAi based screen in Drosophila larvae identifies fascin as a regulator of myoblast fusion and myotendinous junction structure
... for the identification of genes that are necessary for muscle development. Indeed, many screens for regulators of muscle development have been completed. Researchers have used adult locomotion [17] and embryonic muscle ...
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WNT/β catenin signaling plays a crucial role in myoblast fusion through regulation of nephrin expression during development
... and fusion of ...in myoblast differentiation and fusion due to compromised WNT/ β -catenin signaling mediated by RSPO2 (Han et ...a fusion defect in C2C12 cells (Cirillo et ...inhibits ...
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PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site
... for myoblast fusion. (A) Sequestration of PI(4,5)P2 leads to myoblast fusion ...mild fusion defect. Increasing copy number produces a highly penetrant fusion block, with a ...
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Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions
... Skeletal muscle development and function are dependent on 1 integrins, a family of cell surface receptors that are formed by heterodimerization of the 1 subunit with different subunits (Hynes, 1992). In skeletal ...
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Internalization and fate of silica nanoparticles in C2C12 skeletal muscle cells: evidence of a beneficial effect on myoblast fusion
... Abstract: The use of silica nanoparticles for their cellular uptake capability opens up new fields in biomedical research. Among the toxicological effects associated with their internaliza- tion, silica nanoparticles ...
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A TGFβ Smad4 Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development
... The expression patterns of Fgf6 and Fgfr4 transcripts are not completely overlapping in the tongues of E12.5 to E16.5 mouse embryos. Fgfr4 transcripts are more widespread than Fgf6 transcripts. The Fgf6 expression ...
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HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth
... inhibit myoblast fusion, although its effect may depend upon its concentration and the stage of fusion (Leikina et ...increases myoblast permissiveness to fusion and that the failure of ...
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HACD1, a regulator of membrane composition and fluidity, promotes myoblast fusion and skeletal muscle growth
... Defective fusion events were highlighted by a severe reduction in the number of nuclei per sh-Hacd 1 myotube, compared with controls (Figure 6 C and D), Figure 3 Defective myoblast fusion in HACD 1 ...
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Myoblast fusion: lessons from flies and mice
... inhibit myoblast fusion with myotubes (Lafuste et ...membrane fusion (Charrasse et ...to myoblast fusion has been shown are summarized in ...
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Myoblast fusion confusion: the resolution begins
... mammalian myoblast fusion involves the role of phospholipid membrane constituents such as phosphatidylserine ...that myoblast differ- entiation leads to a non-apoptotic transient exposure of PS that ...
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Mind bomb 2, a founder myoblast specific protein, regulates myoblast fusion and muscle stability
... whereas fusion- competent myoblasts (FCMs) acquire this information after fusing to ...of myoblast fusion is compromised, as FMs undergo a reduced number of rounds of fusion with ...The ...
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Synthesis and secretion of a 38 kDa glycopolypeptide coincides with L6 myoblast fusion
... Int I De\' BioI 37 305 310 (1993) 305 Original Article Synthesis and secretion of a 38 kDA glycopolypeptide coincides with L6 myoblast fusion KALERVO METSIKKO* and H KALERVO VAANANEN Department of Ana[.] ...
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Continuous exposure of isoprenaline inhibits myoblast differentiation and fusion through PKA/ERK1/2-FOXO1 signaling pathway
... blast fusion in a time-dependent ...of myoblast fusion in myotubes in- creased gradually and reached the peak on the 6th day (Additional file 1: Figure ...
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CEP2 Attenuates Myoblast Differentiation But Does Not Affect Proliferation
... regulates myoblast fusion by recruiting F-actin and other molecules to the sites of cell-cell contact in vitro and in vivo [17, ...for fusion, myoblasts extend lamellipodium and filo- podia for ...
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FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1)
... of myoblast differentiation in C2C12 myoblasts overexpressing FRG1 and as such has expanded upon the current knowledge of the effect of increased ...of myoblast differentia- tion, as there was no decrease ...
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