Myocyte hypertrophy
A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy
... We have used adenoviral-mediated gene transfer of a consti- tutively active (V12rac1) and dominant negative (N17rac1) isoform of rac1 to assess the role of this small GTPase in cardiac myocyte hypertrophy. ...
10
Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy
... cardiac myocyte hypertrophy and potentially obscures operation of the Frank-Starling mechanism in individual car- diac ...that hypertrophy of surviving ventricu- lar cardiac myocytes was not observed ...
13
Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy
... cardiac myocyte hypertrophy in response to other agonists such as endothelin-1 and phenylephrine, and to pressure overload, suggests that the predomi- nant mechanism of action includes mechanisms that are ...
10
Suppressor of cytokine signaling 3 is a biomechanical stress–inducible gene that suppresses gp130 mediated cardiac myocyte hypertrophy and survival pathways
... The gp130 cytokine receptor activates a cardiomyocyte survival pathway during the transition to heart failure following the biomechanical stress of pressure overload. Although gp130 activation is observed transiently ...
10
Methotrexate carried in lipid core nanoparticles reduces myocardial infarction size and improves cardiac function in rats
... fraction, myocyte hypertrophy, macrophage pres- ence, and A2a and A2b adenosine ...by myocyte marker troponin I, macrophages, and A2a and A2b adenosine ...
18
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy
... cardiac myocyte hypertrophy in ...Total myocyte protein content was determined as previously described ...cardiac myocyte culture medium without Morpholino antisense oligo, and myocytes were ...
13
Oxidant stress from nitric oxide synthase–3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load
... stimulates hypertrophy, often leading to chamber dilation and ...cardiac hypertrophy, dilation, and ...concentric hypertrophy to TAC with preserved ...fibrosis, myocyte hypertrophy, and ...
12
Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II B–depleted mice
... In summary, we have demonstrated that by lowering the amount of NMHC-B mRNA and protein, we pro- duced mice that permit the study of the gradual devel- opment of defects that can serve as valuable models for human ...
10
Pivotal role of cardiomyocyte TGF β signaling in the murine pathological response to sustained pressure overload
... The cardiac pathological response to sustained pressure overload involves myocyte hypertrophy and dysfunction along with interstitial changes such as fibrosis and reduced capillary density. These changes ...
13
Thyroid hormone improves function and Ca2+ handling in pressure overload hypertrophy Association with increased sarcoplasmic reticulum Ca2+ ATPase and alpha myosin heavy chain in rat hearts
... of myocyte hypertrophy or the banding protocol (the shorter duration more severe and longer dura- tion less severe banding caused decompensated LVH in 44 and 40% of hearts, ...
9
UNUSUAL AND RARE PRESENTATION OF HYPOTHYROIDISM (HOFFMAN SYNDROME)
... was hypertrophy of bilateral calf muscles (gastrocnemius) without any associated tenderness [Figures ...No hypertrophy of thigh, arm, or any other muscle group was ...
5
A mechanistic role for cardiac myocyte apoptosis in heart failure
... myocyte apoptosis on cardiac structure and function could be evaluated. Clearly, the rapidity and magnitude of cell death following FK1012H2-induced caspase acti- vation did not accurately model the very low ...
9
Exercise for the heart: signaling pathways
... development, hypertrophy, and angiogenesis ...of hypertrophy including transverse aortic constriction (TAC), Akt transgenic mice and endurance ...cardiac hypertrophy both in physiological and ...
12
Adaptations to iron deficiency: cardiac functional responsiveness to norepinephrine, arterial remodeling, and the effect of beta-blockade on cardiac hypertrophy
... cardiac hypertrophy is not caused by chronic stimulation of beta-adrenergic receptors in the ...cause hypertrophy, and that various forms of hypertrophy are linked to a de- crease in either ...
10
Original Article Evodiamine attenuates pressure overload-induced cardiac hypertrophy
... phy through activation of β-adrenergic receptor and depended on a complex mechanism, including activation of Erk1/2 and G proteins [28]. In our study, increased expression levels of the phosphorylated Erk1/2, JNK, and ...
12
Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy
... Irisin injection induces muscle hypertrophy. We injected 5- week-old mice with either DB or recombinant irisin protein. Quantification of circulating irisin revealed that there was a sig- nificant increase in irisin ...
17
PubMedCentral-PMC5453669.pdf
... We next aim to further define how MuRF1 inhibits T3-induced cardiomyocyte hypertrophy mechanistically. We focused our attention on MuRF1’s regulation of thyroid receptor (TR) TRα1 activity, as it is the only ...
32
Ets 1 is a critical regulator of Ang II mediated vascular inflammation and remodeling
... The role of Ets-1 as a regulator of VSMC function has been less well studied. Ets-1 is induced in VSMCs in response to a variety of stimuli including Ang II, PDGF-BB, and TNF-α (21–23). The pur- pose of this study was to ...
10
Irisin treatment improves healing of dystrophic skeletal muscle
... Initially, we assessed the effect of exogenous Irisin treatment on young (3-week-old) mdx mice undergoing acute dystrophic muscle loss. It is important to mention that we did not observe any adverse effects on the mice ...
14
Urinary bladder hypertrophy and overactive bladder determine urinary continence after radical prostatectomy
... Considering the above-mentioned data, urinary bladder wall hypertrophy and functional disorder of the urinary bladder (e.g., OAB) are important factors affecting urinary continence after RP. Overactive bladder may ...
9