myofibroblast differentiation
Sialylation regulates myofibroblast differentiation of human skin fibroblasts
... inhibits myofibroblast differentiation in serum- free conditions ...myofibroblast differentiation. It is known that the ability of myofibroblast to differentiate is cell context- ...
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Role of ROCK isoforms in regulation of stiffness induced myofibroblast differentiation in lung fibrosis
... stiffness changes and subsequent activation of mechanotransduction pathways in fibrosis. However, given the high degree of homology within the kinase domain and the downstream pathway redundancy between two ROCK ...
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Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis
... Smad2/3 is a major pro-fibrotic signaling molecule that can activate α-SMA promoter activity and promote myofibroblast differentiation. Examination of p-Smad2/3 by immunofluorescent staining and Western ...
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Osteopontin enhances multi-walled carbon nanotube-triggered lung fibrosis by promoting TGF-β1 activation and myofibroblast differentiation
... Numerous studies on experimental animals demonstrate that exposure to CNTs potently induces lung fibrosis; moreover, CNT-induced lung fibrosis exhibits a consid- erable similarity to induced or idiopathic lung fibrosing ...
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Silica Perturbs Primary Cilia and Causes Myofibroblast Differentiation during Silicosis by Reduction of the KIF3A-Repressor GLI3 Complex
... for myofibroblast differentiation regulated by coordination and transduction of fibrotic morphogen signalling pathways ...TGF-β1-triggered myofibroblast activation and contractile functions, which ...
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Activin a promotes myofibroblast differentiation of endometrial mesenchymal stem cells via STAT3-dependent Smad/CTGF pathway
... promotes myofibroblast differentiation of endometrial MSCs (In ...blast differentiation of endometrial MSCs potentially contributes to fibrogenesis in ...of myofibroblast ...
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Curdione ameliorates bleomycin-induced pulmonary fibrosis by repressing TGF-β-induced fibroblast to myofibroblast differentiation
... To address this feasibility, we induced pulmonary fi- brosis in mice and then assessed the impact of curdione on the disease development. Remarkably, treatment with curdione provided protection for mice against BLM- ...
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Original Article DIM attenuates TGF-β1-induced myofibroblast differentiation in neonatal rat cardiac fibroblasts
... [9] Santiago JJ, Dangerfield AL, Rattan SG, Bathe KL, Cunnington RH, Raizman JE, Bedosky KM, Freed D, Kardami E, Dixon IM. Cardiac fibro- blast to myofibroblast differentiation in vivo and in vitro: ...
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Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo
... to myofibroblast differentiation (FMD) is a crucial step for the genesis of ...induced myofibroblast markers as well as mRNA levels of potent profibrotic cytokines and proteins such as CTGF and ...
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Pirfenidone inhibits myofibroblast differentiation and lung fibrosis development during insufficient mitophagy
... of myofibroblast differenti- ation in LF, ATG5, ATG7, and PARK2 knockdown experiments were performed, ...of myofibroblast differentiation), regardless of TGF-β treatment in control siRNA transfected ...
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TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice
... the differentiation of chondrocytes, osteoclasts, and cardiac myofibroblasts ...lung myofibroblast differentiation, we performed knockdown of TRPV4 in HLFs with TRPV4 siRNA before induction of ...
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M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis
... the differentiation of ...the myofibroblast differenti- ation of LR-MSCs, evidenced by the expression of α ...all myofibroblast, how- ever, α -SMA, especially when expressed at a high level, re- ...
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Follistatin Mitigates Myofibroblast Differentiation and Collagen Synthesis of Fibroblasts from Scar Tissue around Injured Flexor Tendons
... Protein expressions of TIMP-1, -2, -4 A-D and fibronectin E in fibroblast from adhesion tissue in patients with zone II flexor tendon repair and transfection with/without adenovirus foll[r] ...
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Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis
... to myofibroblast differentiation was initiated by replacing the starvation medium with starvation medium containing a mixture of Ficoll 70 and 400 (GE Healthcare; ...
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Constitutive AKT Activity Predisposes Lung Fibrosis by Regulating Macrophage, Myofibroblast and Fibrocyte Recruitment and Changes in Autophagy
... Interestingly, the regulation of autophagy may be cell-specific. Araya et al. re- ported that activating autophagy in human bronchial epithelial cells suppresses endoplasmic reticulum (ER) stress and cell senescence ...
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Acute lung injury by gastric fluid instillation: activation of myofibroblast apoptosis during injury resolution
... the myofibroblast is an apoptosis resistant-cell type in many pathological conditions that are characterized by persistent fibrosis ...for myofibroblast differentiation ...
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High-throughput screening discovers antifibrotic properties of haloperidol by hindering myofibroblast activation
... of myofibroblast activation ...induced myofibroblast differentiation, although this channel essentially controls calcium influx from the extracellular space and not its release from the ER, as in our ...
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miR-145 Contributes to Hypertrophic Scarring of the Skin by Inducing Myofibroblast Activity
... α-SMA is the main contributor to con- tractile force generation in myofibrob- lasts. In hypertrophic scarring, myofi- broblast contractility is one of the major problems, since it causes irreversible tis- sue contracture ...
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Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis
... local myofibroblast population to undergo apoptosis has been postulated as a mechanism whereby an acute wound response can become a chronic fibrotic disorder ...and myofibroblast differentiation ...
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Myofibroblast and its role in oral lesions
... The first group relates to granulation tissue and diverse tissue responses, such as burn contractures, pulmonary sarcoidosis, interstitial lung fibrosis, localized and systemic scleroderma, atherosclerotic plaques, ...
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