Myosin Binding Protein-C
Cardiac Myosin Binding Protein C: At the Heart of Hypertrophic Cardiomyopathy in Humans and Domestic Cats
... cardiac myosin binding protein C and associated mutations in the MYBPC3 gene has provided a more comprehensive understanding of hypertrophic cardiomyopathy in humans and domestic ...cMyBP- ...
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HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C
... cardiac myosin binding protein C (MYB- PC3), accounting for more than 50% of cases in which the causative gene has been identified ...myofilament protein found in the C-zone of ...
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Research Progress of Cardiac Myosin Binding Protein C in Dilated Cardiomyopathy and Other Cardiac Conditions
... Since its discovery, myosin-binding protein C (cMyBP-C) has become a pro- tein of interest clinically. With emergence of new methodologies and tech- nologies, the structure and ...
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Dilated cardiomyopathy in homozygous myosin binding protein C mutant mice
... cardiac myosin-binding protein-C (MyBP-C) in myocardial structure and func- tion, we have produced mice expressing altered forms of this sarcomere ...cardiac myosin heavy ...
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The Mechanisms of the Frank-Starling Law and Familial Cardiomyopathy are Different. The Function of Myosin Binding Protein-C is Retained on Myocyte Length Increase and Force Generated is Kinase controlled
... the myosin-bound ATP or the myosin bound products MgADP and Pi or transient ...The Myosin binding Protein-C (MyBP-C) makes Ca 2+ -Mg 2+ exchange or a consequent step ...
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Calcium, Actomyosin Kinetics, Myosin Binding Protein-C and Hypertrophic Cardiomyopathy
... Calcium, Myosin Binding Protein-C and Hypertrophic Cardiomyopathy in the basic function of cardiac ...of myosin binding protein-C is described along with how this ...
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Novel splice donor site mutation in the cardiac myosin binding protein C gene in familial hypertrophic cardiomyopathy Characterization Of cardiac transcript and protein
... Additional protein interactions, localized in the region that binds to titin in vitro (27, 32), appear to be crucial for correct sarcomeric ...tated protein under control of strong viral promoters resulted ...
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A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy
... and myosin binding protein ...MyBP-C protein is completely benign: the cardiomyocyte is able to effectively regulate the overall stoi- chiometry of the MyBP-C ...mutated ...
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Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β cardiac myosin
... generating protein machinery of the cardiac muscle sarcomere, including human β -cardiac myosin, the motor protein that powers ventricular ...non-cardiac myosin, there is no clear consensus ...
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Genetic mutations and mechanisms in dilated cardiomyopathy
... components myosin heavy chain and myosin binding protein C (MYH7 and MYBPC3) together explain 75% of inherited HCMs, leading to the observation that HCM is a disease of the ...
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Interactions of actin, myosin, and an actin binding protein of chronic myelogenous leukemia leukocytes
... Actin, myosin, and a high molecular weight actin-binding protein were purified from chronic myelogenous leukemia (CML) ...muscle myosin. CML leukocyte myosin was similar to other ...
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Identification and characterisation of a type II myosin in the fission yeast <italic>Schizosaccharomyces pombe</italic>
... as myosin II in higher eukaiyotes, it might be expected that Myo2p would be a component of the actin ring and that deletion would have a sim ilar effect as the deletion of other actin ring components which are ...
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Comprehensive Mapping of Receptor-Functioning Domains in Feline Leukemia Virus Subgroup C Receptor FLVCR1
... Isolation of human FLVCR2 cDNA. Homologous sequences to human FLVCR1 cDNA were identified by BLAST (Basic Local Alignment Search Tool, available at http://www.ncbi.nlm.nih.gov/BLAST/) sequence comparison. A cDNA sequence ...
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The normal role of Activated Protein C in maintaining homeostasis and its relevance to critical illness
... The initiation of coagulation, especially in severe sepsis, is probably mediated by the induction of tissue factor (TF) expression by endotoxin. This leads to the activation of factor X, which then combines with factor ...
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Cryoprotective effect of trehalose and maltose on washed and frozen stored beef meat
... semi-purified protein fraction contain- ing a high concentration of myofibrillar ...myofibrillar protein solubility SEP (Salt extractable protein) (Sych et ...
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Role of Oxysterol Binding Protein in Hepatitis C Virus infection
... transfer protein inhibitor and ApoB silencing studies, both of which affect the VLDL particle assembly ...transfer protein in- hibitor and ApoB small interfering RNA affect the accumula- tion of ...
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The role of palladin in actin organization : implications for the glial scar
... F-actin binding in palladin’s relatives myotilin and kettin (von Nandelstadh et ...for binding to filamentous ...actin binding. The Ig4 and Ig5 domains showed no actin-binding activity, ...
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Understanding how ESOL Pre Services Teachers' Prior Experiences and Background Shape their Processes of becoming L2 (Reading) Teachers
... viral protein causing the difference in SG ...and C-terminal regions from Eg101 or a combination of the Eg101 NS1, NS3 and NS4a proteins produced low levels of early viral RNA synthesis support the ...
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Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts
... Interestingly, the β-gal activity in postnatal slow muscle was especially strong at neuromuscular junctions (dark dotted staining patterns in the mid-belly of the muscles; Figure 1G-H). To further examine this ...
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Intestinal epithelial restitution Characterization of a cell culture model and mapping of cytoskeletal elements in migrating cells
... cytoskeletal protein with both F actin bundling and severing capacities, was also expressed at the leading edge in a pattern consistent with a regulatory role in the dynamic restructuring of ...Lastly, ...
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