myxoma virus
Myxoma virus induces extensive CD4 downregulation and dissociation of p56lck in infected rabbit CD4+ T lymphocytes.
... of myxoma virus strain Lausanne containing the Escherichia coli lacZ gene inserted at an innocuous site between the myxoma virus growth factor and M9 genes, and its construction has been ...
9
Infection of Nonhost Species Dendritic Cells In Vitro with an Attenuated Myxoma Virus Induces Gene Expression That Predicts Its Efficacy as a Vaccine Vector
... Recombinant myxoma virus (MYXV) can be produced without a loss of infectivity, and its highly specific host range makes it an ideal vaccine vector candidate, although careful examination of its interaction ...
13
Decrease in C reactive protein levels in rabbits after vaccination with a live attenuated myxoma virus vaccine
... Myxoma virus, a member of the Poxviridae family, is the agent responsible for myxomatosis, a highly lethal disease of the European rabbit (Oryctolagus ...this virus is not a natural pathogen of ...
6
Structural studies of myxoma virus antagonists of innate immunity
... Vaccinia virus protein C7 and its homologues function as determinants of host range by antagonising the immune response via interaction with its poorly understood target ...SAMD9. Myxoma virus (MYXV) ...
229
Myxoma Virus M141R Expresses a Viral CD200 (vOX-2) That Is Responsible for Down-Regulation of Macrophage and T-Cell Activation In Vivo
... CD200, myxoma virus M141R, and HHV-8 ...disease virus of the genus Capripoxvirus (LSDV), leporipoxviruses Shope fibroma virus (SFV) and Myxoma virus (MV), and yatapoxviruses ...
16
Myxoma Virus Induces Type I Interferon Production in Murine Plasmacytoid Dendritic Cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-Dependent Pathway
... Myxoma virus but not vaccinia virus infection of Flt3L- BMDCs induces type I IFN ...to myxoma versus vaccinia virus infection, we generated Flt3L-BMDCs by culturing bone mar- row cells ...
13
Early infections by myxoma virus of young rabbits (Oryctolagus cuniculus) protected by maternal antibodies activate their immune system and enhance herd immunity in wild populations
... of myxoma virus (MYXV) were observed shortly after the introductions of the virus [36,37], with multiples genes being involved in changes in virulence ...
9
Myxoma Virus Encodes an α2,3-Sialyltransferase That Enhances Virulence
... the myxoma virus EcoRI-G2 fragment located 24 kb from the right end of the 163-kb genome has been ...the myxoma virus genome encodes homologs of the vaccinia virus genes A51R, A52R, ...
9
Myxoma virus therapy of human embryonal rhabdomyosarcoma in a nude mouse model
... oncolytic virus therapy can improve outcomes in individuals with RMS, myxoma virus expressing a red fluorescent protein (MYXV-red) was evaluated for antitumoral effects using a murine model of ...
13
M135R Is a Novel Cell Surface Virulence Factor of Myxoma Virus
... Myxoma virus (MV) encodes a cell surface protein (M135R) that is predicted to mimic the host alpha/beta interferon receptor (IFN- ␣ /  -R) and thus prevent IFN- ␣ /  from triggering a host antiviral ...
9
Development of a poxvirus vaccine : the myxoma virus/European rabbit model
... Myxoma virus is the prototype member of the Leporipoxvirus genus, which also includes the antigenically related rabbit (or Shope) fibroma virus (RFV), squirrel fibroma virus and hare fibroma ...
472
Role of the Serine-Threonine Kinase PAK-1 in Myxoma Virus Replication
... support myxoma virus (MV) replication, we investigated the role of host serine-threonine kinases (STKs) as potential mediators of the permissive ...early virus gene expression, indicating that MV ...
12
Molecular characterisation of virulence graded field isolates of myxoma virus
... Myxoma virus (MV) causes myxomatosis in the Eur- opean rabbit (Oryctolagus ...a virus and its host. The complex virus/host relationship has been shown to lead to the emergence of more ...
12
Myxoma Virus M083 Is a Virulence Factor Which Mediates Systemic Dissemination
... leporipoxvirus myxoma virus is a significant virulence factor during infection of sus- ceptible Oryctolagus ...of virus to spread beyond the regional lymph nodes and completely eliminates infection- ...
15
Pathogenesis of myxoma virus
... 24hpi, myxoma virus was present in two cell ...that myxoma virus localised to (Figures ...containing virus costained for MHC class II, sections of 4 to 7 o ft were cut sequentially from ...
403
Induction of Alpha/Beta Interferon by Myxoma Virus Is Selectively Abrogated When Primary Mouse Embryo Fibroblasts Become Immortalized
... in myxoma virus-infected ...with myxoma virus for various amounts of ...top, myxoma virus infection did not initiate any observable change in IRF3 band migration patterns, as re- ...
5
Disruption of M-T5, a novel myxoma virus gene member of poxvirus host range superfamily, results in dramatic attenuation of myxomatosis in infected European rabbits.
... Myxoma virus is a pathogenic poxvirus that induces a lethal myxomatosis disease profile in European rab- bits, which is characterized by fulminating lesions at the primary site of inoculation, rapid ...
17
Genetic Variability of Myxoma Virus Genomes
... 6 myxoma virus (MYXV) strains were sequenced: German field isolates Munich-1, FLI-H, 2604, and 3207; vaccine strain MAV; and chal- lenge strain ...vaccinia virus (VACV) were investigated in the ...
19
In vitro permissivity of bovine cells for wild type and vaccinal myxoma virus strains
... Myxoma virus (MYXV), a leporide-specific poxvirus, represents an attractive candidate for the generation of safe, non-replicative vaccine vector for non-host ...
5
Modulation of the Myxoma Virus Plaque Phenotype by Vaccinia Virus Protein F11
... Vaccinia virus (VACV) produces large plaques consisting of a rapidly expanding ring of infected cells surrounding a lytic core, whereas myxoma virus (MYXV) produces small plaques that resemble a ...
13