N-acetylaspartate
Whole Brain N Acetylaspartate Concentration: Correlation with T2 Weighted Lesion Volume and Expanded Disability Status Scale Score in Cases of Relapsing Remitting Multiple Sclerosis
... To address these concerns, proton MR spectros- copy has been applied to augment T2-weighted MR imaging. In vivo proton MR spectroscopy can be used to noninvasively quantify brain metabolites, such as ...
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Cerebral N acetylaspartate is low in patients with multiple sclerosis and abnormal visual evoked potentials
... METHODS: Seventeen subjects with clinically definite MS were studied with VEPs and MR spectroscopic imaging. Proton MR metabolites were measured using a fast spectroscopic imaging technique called proton echo-planar ...
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The Molecular Mechanisms Affecting N-Acetylaspartate Homeostasis Following Experimental Graded Traumatic Brain Injury
... of N-acetylaspartate (NAA) metabolism following traumatic brain injury (TBI), we measured the NAA, adenosine triphosphate (ATP) and adenosine diphosphate (ADP) concentrations and calculated the ATP/ADP ...
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Reduced N Acetylaspartate Levels in the Frontal Cortex of 3,4 Methylenedioxymethamphetamine (Ecstasy) Users: Preliminary Results
... of N-acetyl groups (primarily N- acetylaspartate [NAA]), choline (Cho)-containing compounds, and creatine (Cr) plus phosphocreatine are present in the ...
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Redirecting N-acetylaspartate metabolism in the central nervous system normalizes myelination and rescues Canavan disease
... N-acetylaspartate (NAA) is one of the most abundant molecules in the mammalian CNS (1, 2). It is synthesized in neurons and hydrolyzed by oligodendroglial aspartoacylase (ASPA). Dysfunction or defi- ciency ...
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AGC1 Deficiency Causes Infantile Epilepsy, Abnormal Myelination, and Reduced N-Acetylaspartate.
... or be a nonspecific finding in epilepsy, although the Swedish AGC1 proband did not have elevated lactate signal on MRS at 2 years, 9 months (Wibom et al. 2009). The muscle biopsy performed after the time of symptomatic ...
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Abnormally High Levels of Brain N Acetylaspartate in Children with Sickle Cell Disease
... Proton MR spectroscopy (MRS) of the human brain makes it possible to measure metabolically important cellular components such as amino acids (including N-acetylaspartate [NAA]), amines, sugars, and bioen- ...
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Localized 1H NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N acetylaspartate
... expressed as arbitrary institutional units and are not cor- rected for contributions by CSF and a small reduction in the numeric values by residual T 1 and T 2 relaxation effects. The data evaluation comprised a ...
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Reproducibility of Three Whole Brain N Acetylaspartate Decline Cohorts in Relapsing Remitting Multiple Sclerosis
... Reproducibility of Three Whole-Brain N-Acetylaspartate Decline Cohorts in Relapsing-Remitting Multiple Sclerosis BACKGROUND AND PURPOSE: The cross-sectional rate of whole-brain N-acetyla[r] ...
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Whole Brain N Acetylaspartate Level and Cognitive Performance in HIV Infection
... of N-acetylaspartate (NAA), a metabolite al- most exclusive to neurons and their axonal and den- dritic extensions (8), and increased levels of choline (Cho) and myo-inositol ...
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Cerebral proton magnetic resonance spectroscopy demonstrates reversibility of N acetylaspartate/creatine in gray matter after delayed encephalopathy due to carbon monoxide intoxication: a case report
... Case presentation: We report the case of a 40-year-old Caucasian woman with severe carbon monoxide poisoning who was treated with five repetitive sessions of hyperbaric oxygen therapy in a multiplace chamber (100 percent ...
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Whole Brain N Acetylaspartate MR Spectroscopic Quantification: Performance Comparison of Metabolite versus Lipid Nulling
... The latter is due to contamination of the NAA peak with intense signals from the bone marrow and subcutaneous adipose tissue,14,15 as shown in Fig 1, thereby excluding most of the cortex[r] ...
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Proton MR Spectroscopy: Higher Right Anterior Cingulate N Acetylaspartate/Choline Ratio in Asperger Syndrome Compared with Healthy Controls
... On the other hand, a further study reported no differences in the NAA/Cho ratio.10 To date, neuroimaging data indicate that the anterior cingulate and dorsolateral prefrontal cortex may [r] ...
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Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice
... Mice were sacrificed after MRS scan. 1% Pentobarbital Sodium (701O031, Solarbio, China) was used to anesthe- tize animals (50 mg/kg) by intraperitoneal injection. The brain was removed and kept in 4 °C environment imme- ...
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Longitudinal Whole Brain N Acetylaspartate Concentration in Healthy Adults
... The individual distribution of WBNAA values at baseline was not significantly different from the follow-up points with respect to its mean (P ⬎ .6), as shown in Fig 2. The intrasubject WBNAA level did not change ...
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Whole Brain N Acetylaspartate as a Surrogate Marker of Neuronal Damage in Diffuse Neurologic Disorders
... For SPMS, the most convincing data favors mitoxantrone Novantrone as most likely to retard progression and delay disability.46-48 Extensive 1H-MR spectroscopy studies to characterize the[r] ...
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Global N Acetylaspartate Declines Even in Benign Multiple Sclerosis
... Discussion Despite the importance of prospective prognostic metrics for a benign MS course, the attempts to identify these have so far proved elusive, yielding no true consensus.9 Variou[r] ...
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Prefrontal N Acetylaspartate and Poststroke Recovery: A Longitudinal Proton Spectroscopy Study
... To assess the hypothesis that NAA/Cr increases in the contralesional hemisphere would be best associated with clinical improvement on the SSS, we used the general linear model/repeated-m[r] ...
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Whole Brain N Acetylaspartate Concentration Is Preserved during Mild Hypercapnia Challenge
... To test the hypothesis and to quantify the hereto unknown effects of hypercapnia on NAA, we used whole-brain NAA WBNAA nonlocalizing 1H-MR spectroscopy18,19 and compared its changes with[r] ...
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The effect of atypical antipsychotics on brain N-acetylaspartate levels in antipsychotic-naïve first-episode patients with schizophrenia: a preliminary study
... worth noting that the patients treated within the framework of the above study received olanzapine, which failed to yield a rise in NAA levels in the examinees (N = 10) despite the achieved therapeutic response. ...
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