N-acetylcysteine
N-acetylcysteine overdose after acetaminophen poisoning
... Abstract: N-acetylcysteine (NAC) is used widely and effectively in oral and intravenous forms as a specific antidote for acetaminophen poisoning. Here we report a rare case of iatrogenic NAC overdose ...
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Electrochemical Determination of N-acetylcysteine and Folic Acid in Pharmaceutical and Biological Samples Using a Modified Carbon Nanotube Paste Electrode
... The reliability of the proposed modified electrode was also evaluated by comparing the obtained results with those declared in the label of the pharmaceutical preparations (Table 3). The results in table 2 show the ...
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N-acetylcysteine attenuates cardiopulmonary bypass-induced lung injury in dogs
... N-acetylcysteine (NAC) is an antioxidant that could scavenge oxygen free radicals with protective effects on cells and microcirculation [17]. NAC is able to alleviate lung reperfusion injury induced by deep ...
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Effect of N-acetylcysteine on exacerbations of bronchiectasis (BENE): a randomized controlled trial
... of N-acetylcysteine for the treatment of bronchiectasis in ...of N-acetylcysteine on a Chinese population might differ from that in other ...compare N-acetylcysteine to a ...
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Dilution of Intravenous N -Acetylcysteine as a Cause of Hyponatremia
... accidentally ingested 240 mg/kg of acet- aminophen. She was brought to a local hos- pital where her blood work 4 hours after ingestion showed a serum sodium of 141 mmol/L and an acetaminophen level of 1701 mmol/L. A drug ...
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N-acetylcysteine improves established monocrotaline-induced pulmonary hypertension in rats
... Background: The outcome of patients suffering from pulmonary arterial hypertension (PAH) are predominantly determined by the response of the right ventricle to the increase afterload secondary to high vascular pulmonary ...
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The impact of N acetylcysteine and ascorbic acid in contrast induced nephropathy in critical care patients: an open label randomized controlled study
... (NacA, n = 60) received intravenously N-acetylcysteine (1200 mg) and ascorbic acid (2 g) dissolved separately in 100 ml of normal saline 2 hours before, and at 10 hours and 18 hours following the ...
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AVERTING CANCER EFFECT OF PARACETAMOL AND PHENACETIN BY N ACETYLCYSTEINE AND ITS ANALOGUES
... of N-acetylcysteine (NAC), N-acetylmethionine (NAM) or N-acetylglucoseamine (NAGA) prevents the formation of m-PA, ...of N- acetylcysteine, N-acetylmethionine or ...
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Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy
... Gastrointestinal malignancies account for more than one third of all deaths from cancer worldwide [1]. Repre- senting the most common gastrointestinal cancers [2], colorectal and gastric cancers have the potential to ...
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Effect of N-acetylcysteine in COPD patients with different microsomal epoxide hydrolase genotypes
... Background: The role of the antioxidant N-acetylcysteine (NAC) in the treatment of chronic obstructive pulmonary disease (COPD) has not been clarified as yet. In early studies, we found that the proportion ...
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Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive pulmonary disease
... Abstract: Chronic obstructive pulmonary disease (COPD) is a common and morbid disease characterized by high oxidative stress. Its pathogenesis is complex, and involves excessive oxi- dative stress (redox imbalance), ...
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N acetylcysteine as add on to antidepressant medication in therapy refractory major depressive disorder patients with increased inflammatory activity: study protocol of a double blind randomized placebo controlled trial
... A recent clinical study has shown beneficial effects of anti-inflammatory co-medication with antidepressants in depressed patients with increased levels of peripheral inflammation [16]. This is in line with a study by ...
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Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12 h regimen of N acetylcysteine for paracetamol overdose—the PP100–01 for Overdose of Paracetamol (POP) trial: study protocol for a randomised controlled trial
... death. Acetylcysteine (N-acetylcysteine (NAC)) was de- veloped as an antidote for APAP poisoning in the 1970s and remains the mainstay for the prevention of APAP-induced ...
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Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis
... of N-Acetylcysteine High Dose in Exacerbations of Chronic Obstructive Pulmonary Disease (PANTHEON study) [1] has documented that in patients with moderate-to-severe chronic obstructive pulmonary disease ...
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Prevention of doxorubicin cardiac toxicity in the mouse by N acetylcysteine
... This study was undertaken to investigate the effect of exogenous sulfhydryl compound administration on the toxicity of doxorubicin in mice. Pretreatment of CDF1 mice with a pharmacologic dose (2,000 mg/kg) of ...
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N-ACETYLCYSTEINE: POTENTIAL PHARMACOTHERAPY FOR WITHDRAWAL SYMPTOMS IN METHAMPHETAMINE USERS
... Administration of N-acetylcysteine more than 1.2 g/day might induce headache, tinnitus, urticaria, and skin rash. Additionally, this drug is prohibited for pregnant women and history of drug allergenicity. ...
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N -acetylcysteine negatively regulates Notch3 and its malignant signaling
... Notch3 receptor is expressed in a variety of cancers and the excised active intracellular domain (N3ICD) initiates its signaling cascade. N-acetylcysteine (NAC) as an antioxidant has been implicated in ...
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Therapeutic effects of N-acetylcysteine against malathion-induced hepatotoxicity
... NAC: N -Acetylcysteine; PCR: Polymerase chain reaction; RNA: Ribonucleic acid; ROS: Reactive oxygen species; RT-PCR: Reverse transcription polymerase chain ...
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N Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin
... and N-acetylcysteine 2 min before maximal inhibition of ADP- induced aggregation was achieved, while simultaneously measured cyclic AMP did not change relative to base-line ...of ...
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The neuroprotective effect of N-acetylcysteine in spinal cord-injured rats
... All the procedures were performed in accordance with EU animal protection laws and were approved by the Local Ani- mal Research Ethics Committee. Twenty adult male Wistar C rats (approximate body weight: 300 g) were ...
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