N-acetylglucosamine
Structure-based drug design studies of UDP-N-acetylglucosamine pyrophosphosrylase, a key enzyme for the control of witches’ broom disease
... and N-acetylglucosaminyl ...and N-acetylglucosamine-1- phosphate ...Val260). N-acetylglucosamine is also recog- nized by hydrogen bonds, and it is possible to observe a hydrophobic ...
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Designing and Cloning Molecular Constructs to Knock Out N-Acetylglucosamine Phosphatidylinositol De-N-Acetylase (GPI12) Gene in Leishmania major (MRHO/IR/75/ER)
... Nevertheless, a controlled vaccination with living strains has met some success. One way to begin to create new vaccine and drugs is through the evaluation of important enzymes, proteins and macromolecules by reverse ge- ...
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The involvement of beta-1,4-galactosyltransferase and N-acetylglucosamine residues in fertilization has been lost in the horse
... recognizes N-Acetylglucosamine residues on a glycoprotein ...and N-Acetylglucosamine residues in sperm-zona pellucida binding in ...and N-Acetylglucosamine residues have been ...
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N-Acetylglucosamine Induces White-to-Opaque Switching and Mating in Candida tropicalis, Providing New Insights into Adaptation and Fungal Sexual Evolution
... Pathogenic fungi are capable of switching between different phenotypes, each of which has a different biological advantage. In the most prevalent human fungal pathogen, Candida albicans, phenotypic transitions not only ...
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Regulation of miR-483-3p by the O-linked N-acetylglucosamine transferase links chemosensitivity to glucose metabolism in liver cancer cells.
... a N-acetylglucosamine in O-glycosidic linkage (O-GlcNAcylation) to serine or threonine residues 16,17 and in fl uences several cellular processes, such as epigenetic control of RNA transcription, 18 insulin ...
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Production of poly-β-1, 6-N-acetylglucosamine by MatAB is required for hyphal aggregation and hydrophilic surface adhesion by Streptomyces
... Recently we discovered a novel locus encompassing the matA and matB genes, which likely encode biosynthetic enzymes for an extracellular polymeric substance (EPS) and are also required for pellet formation [29]. Deletion ...
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O-linked N-acetylglucosamine transferase promotes cervical cancer tumorigenesis through human papillomaviruses E6 and E7 oncogenes
... O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) increases O-GlcNAc modification (O-GlcNAcylation), and transcriptional co-regulator host cell factor 1 (HCF-1) is one of OGT ...
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UDP N Acetylglucosamine 4 Epimerase Activity Indicates the Presence of N Acetylgalactosamine in Exopolysaccharides of Streptococcus thermophilus Strains
... The biosynthesis of bacterial EPS is initiated by the synthesis of the repeating units of sugar nucleotides (9a). The incorpo- ration of the constituting activated monosaccharides into these EPS repeating units will ...
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Poly N Acetylglucosamine Expression by Wild Type Yersinia pestis Is Maximal at Mammalian, Not Flea, Temperatures
... IMPORTANCE Yersinia pestis transitions from low-temperature residence and replication in insect vectors to higher-temperature replication in mammalian hosts. Prior findings based primarily on an avirulent derivative of ...
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Combinatorial pathway enzyme engineering and host engineering overcomes pyruvate overflow and enhances overproduction of N-acetylglucosamine in Bacillus subtilis
... Background: Glucosamine-6-phosphate N-acetyltransferase (GNA1) is the key enzyme that causes overproduction of N-acetylglucosamine in Bacillus subtilis. Previously, we increased GlcNAc production by ...
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Inhibition of O-Linked N-Acetylglucosamine Transferase Reduces Replication of Herpes Simplex Virus and Human Cytomegalovirus
... O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) is an essential cellular enzyme that posttranslationally modifies nuclear and cytoplasmic proteins via O-linked addition of a single ...
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Two O-Linked N-Acetylglucosamine Transferase Genes of Arabidopsis thaliana L. Heynh. Have Overlapping Functions Necessary for Gamete and Seed Development
... The Arabidopsis SECRET AGENT (SEC) and SPINDLY (SPY) proteins are similar to animal O -linked N-acetylglucosamine transferases (OGTs). OGTs catalyze the transfer of N-acetylglucosamine ...
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N-Acetylglucosamine Metabolism Promotes Survival of Candida albicans in the Phagosome
... with N-acetylglucosamine induces rapid pH ...with N-acetylglucosamine (GlcNAc) as the sole carbon source can also promote neutralization of the ambient pH ...
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The Plant Pathogen Xanthomonas campestris pv campestris Exploits N Acetylglucosamine during Infection
... ABSTRACT N-Acetylglucosamine (GlcNAc), the main component of chitin and a major constituent of bacterial peptidoglycan, is present only in trace amounts in plants, in contrast to the huge amount of various ...
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Deficiency of UDP galactose:N acetylglucosamine β 1,4 galactosyltransferase I causes the congenital disorder of glycosylation type IId
... terminal N- acetylglucosamine residues of complex-type oligosac- charides in newly synthesized glycoproteins in the Golgi apparatus, is the cause of a new type of CDG-II, designated ...
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N Acetylglucosamine Induced Cell Death in Candida albicans and Its Implications for Adaptive Mechanisms of Nutrient Sensing in Yeasts
... as N-acetylglucosamine (GlcNAc) and other poly- saccharides broken down from the intestinal mucosa or bacterial cell wall components could be used as primary energy and carbon sources (12, ...
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A Poly N Acetylglucosamine−Shiga Toxin Broad Spectrum Conjugate Vaccine for Shiga Toxin Producing Escherichia coli
... -(1⫺6)-linked N-acetylglucosamine units, is a widely conserved carbohydrate that has been detected on the sur- face of a broad range of pathogens following its discovery in Staph- ylococcus epidermidis and ...
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Fibroblasts from patients with I cell disease and pseudo Hurler polydystrophy are deficient in uridine 5' diphosphate N acetylglucosamine: glycoprotein N acetylglucosaminylphosphotransferase activity
... acetylglucosamine:glycoprotein N-acetylglucosaminylphosphotransferase, the first enzyme of the ...The N-acetylglucosaminylphosphotransferase activity (assayed using endogenous acceptors) in cultures from ...
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N-Acetylglucosamine (GlcNAc)-Inducible Gene GIG2 Is a Novel Component of GlcNAc Metabolism in Candida albicans
... is N-acetylglucosamine (GlcNAc), which is now established as an important carbon source for many pathogens and can also act as a signaling ...of N-acetylneuraminate (sialic acid), a molecule equally ...
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Transmembrane Molecules for Phylogenetic Analyses of Pathogenic Protists: Leishmania-Specific Informative Sites in Hydrophilic Loops of Trans- Endoplasmic Reticulum N-Acetylglucosamine-1-Phosphate Transferase
... A sequence database was created for the Leishmania N-acetylglucosamine-1-phosphate transferase (nagt) gene from 193 independent isolates. PCR products of this single-copy gene were analyzed for restriction ...
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