N-Cadherin
Metformin represses cancer cells via alternate pathways in N-cadherin expressing vs. N-cadherin deficient cells
... in N-cadherin leads to up-regulation of NF-kappaB ...is N-cadherin dependent may also be linked to NF-kappaB ...regulated N-cadherin, p65 and its downstream molecules (c-FLIP and ...
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Original Article Evaluation of the correlativity of gender determining region Y-box 4, N-cadherin, CD44 and E-cadherin expression in the prognosis of esophageal squamous cell carcinoma
... SOX4, N-cadherin and CD44 in ...SOX4, N-cadherin and CD44 was significantly worse than that of ESCC patients with heterogeneous expression of these markers or co-expression of SOX4, ...
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Differential expression of E-cadherin, N-cadherin and beta-catenin in proximal and distal segments of the rat nephron.
... E-cadherin, N-cadherin and β-catenin labeling were captured using a gain setting of 16 for FITC and 8 for TRITC, and exposure times of 3 s for green and 1 s for red and ...of cadherin labeling ...
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Differential effects of N cadherin mediated adhesion on the development of myotomal waves
... endogenous cadherin by competing for interactions with cytoskeletal components, resulting in the abrogation of cadherin-mediated cell adhesion (Fujimori and Takeichi, ...that N- ...
12
Probing Cadherin Interactions in Zebrafish with E- and N-Cadherin Missense Mutants
... and N-cadherin are classically thought to be homophilic, forming only homodimers with ...of cadherin quickly aggregated with each other and could not aggregate with cells transfected with a differ- ...
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Original Article Clinical usefulness of immunohistochemistry for plakoglobin, N-cadherin, and connexin-43 in the diagnosis of arrhythmogenic right ventricular cardiomyopathy
... In conclusion, we identified that the immuno- histochemical analysis for plakoglobin had a relatively high sensitivity and specificity in ARVC. However, immunohistochemical analysis of plakoglobin was slightly ...
8
Replacement of E cadherin by N cadherin in the mammary gland leads to fibrocystic changes and tumor formation
... supported by the fact that the mesenchymal marker Vimentin was highly upregulated in the MG of these mice (Figure 6B). Transcription factors of the Snail family have been shown to be essential for the initiation of EMT. ...
16
N cadherin can structurally substitute for E cadherin during intestinal development but leads to polyp formation
... The observed phenotype, including the formation of polyps, can be predominantly attributed to an enhanced nuclear function of - cat, consistent with data from mice and humans (Augenlicht et al., 1997; Dalerba et al., ...
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Analysis of the promoter region of the Xenopus borealis N Cadherin gene
... their Cadherin-mediated cell-cell aggregation ability ...individual Cadherin molecule does not in itself have the ’strength' to mediate cell-cell binding: it needs to be attached to an underlying framework, ...
343
Matrix metalloproteinase activity stimulates N-cadherin shedding and the soluble N-cadherin ectodomain promotes classical microglial activation
... Soluble N-cdh-dependent microglial activation is of ...That N-cdh stimulated an increase in TNF- α release is of interest in that this cytokine is typically associated with classical or pro-inflammatory M1 ...
12
<p>12-lipoxygenase promotes tumor progress by TGF-β1-mediated epithelial to mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma</p>
... 1:1000), N-cadherin (Proteintech, USA, diluted 1:1000), E-cadherin (CST, USA, diluted 1:1000) and GAPDH (Santa Cruz Biotechnology, USA, diluted 1:2000) for 4°C ...
11
Interleukin-32α inactivates JAK2/STAT3 signaling and reverses interleukin-6-induced epithelial–mesenchymal transition, invasion, and metastasis in pancreatic cancer cells
... E-cadherin, N-cadherin, Vimentin, Snail, and Zeb1, as well as extracellular matrix metalloproteinases (MMPs), including MMP2, MMP7, and MMP9, were detected by immunofluorescence, Western blotting, ...
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TLX3 repressed SNAI1-induced epithelial-mesenchymal transition by directly constraining STAT3 phosphorylation and functionally sensitized 5-FU chemotherapy in hepatocellular carcinoma
... IL-6/STAT3 signaling has been implicated in the induction of EMT in a variety of cancers [40, 41]. However, the mechanism underlying the process is not completely understood. Kim et al. previously proposed that ...
16
miR-200c suppresses endometriosis by targeting MALAT1 in vitro and in vivo
... Results: Exogenous overexpression of miR-200c inhibited the proliferation and migration of HESCs, which were mainly regulated by metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). In contrast, inhibition of ...
11
Inhibition of ATM reverses EMT and decreases metastatic potential of cisplatin-resistant lung cancer cells through JAK/STAT3/PD-L1 pathway
... E-cadherin, N-cadherin, Vimentin, Snail (Cell Signaling, Danvers, MA), and ATM (Bethyl Laboratories, Montgomery, TX) (all antibodies at 1:250 dilution) were applied in ...
14
Lysophosphatidic acid stimulates epithelial to mesenchymal transition marker Slug/Snail2 in ovarian cancer cells via Gαi2, Src, and HIF1α signaling nexus
... HIF1α activation remain to be elucidated. Therefore, we set out to determine if LPA signaling could enhance the levels of HIF1α and subsequent EMT of ovarian cancer cells in a hypoxic environment. To test, ovarian cancer ...
16
Original Article GM130 regulates epithelial-to-mesenchymal transition and invasion of gastric cancer cells via snail
... may promote EMT in gastric cancer cells. High metastatic gastric cancer cell line (MKN-45) demonstrated elevated GM130 expression, were spindle shaped and exhibited reduced cell contact. GM130 knockdown resulted in a ...
8
<p>PNUTS mediates ionizing radiation-induced CNE-2 nasopharyngeal carcinoma cell migration, invasion, and epithelial–mesenchymal transition via the PI3K/AKT signaling pathway</p>
... Notes: (A, B) cne-2 cells were transfected with si-nc or si-PnUTs. Quantitative real-time Pcr and Western blotting were used to evaluate PnUTs mrna and protein expression levels, respectively. (C) after cne-2 cells were ...
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ERK5 negatively regulates tobacco smoke-induced pulmonary epithelial–mesenchymal transition
... To further determine the role of ERK5 in TS- triggered EMT, NHBE cells were transfected with lentiviral ERK5 expression vector at multiplicity of infection (MOI) of 2.5, 5, 10, 25 and 50 for 72 hours. Green fluorescent ...
14
Expression profiling of adhesion proteins during prenatal and postnatal liver development in rats
... E-cadherin, N-cadherin, epithelial CAM (EpCAM), intracellular CAM (ICAM), collagen 1α1, α-actinin, β-catenin and vimentin, in the liver tissue during prenatal and postnatal ...E-cadherin, ...
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