N-end rule pathway
The N end rule pathway promotes seed germination and establishment through removal of ABA sensitivity in Arabidopsis
... the N-end rule pathway have been identified in Arabidopsis, including PRT1 (4, 6) and ATE ...this pathway acts through bulk degradation of proteins in imbibed seeds, since we did not ...
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Enhanced waterlogging tolerance in barley by manipulation of expression of the N end rule pathway E3 ligase PROTEOLYSIS6
... exposed N-terminal Cys residue is vulnerable to oxidation, which permits subsequent arginylation by Arg-tRNA protein transferases (ATEs; Figure 1a), followed by ubiquitination by N-recognins recognizing the ...
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The Cys Arg/N end rule pathway is a general sensor of abiotic stress in flowering plants
... Cys-Arg/N- end rule pathway controls homeostatic response of plants to low oxygen and nitric oxide (NO) through controlled degradation of group VII Ethylene Response Factor (ERFVII) ...
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The Cys Arg/N end rule pathway is a general sensor of abiotic stress in flowering plants
... the N-end rule ...from N-end rule regulation [1], enhances response to drought following flooding ...the N-end rule pathway plays an opposite role in ...
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Quantitative proteomics analysis of the Arg/N-end rule pathway of targeted degradation in Arabidopsis roots
... tein N-termini ...in N-end rule mutants, indicating that proteins initiating with destabilising residues are not necessarily targeted for ...secretory pathway, many neo-Nt peptides ...
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Ubiquitin conjugation by the N end rule pathway and mRNAs for its components increase in muscles of diabetic rats
... (Ub-proteasome) pathway, we investigated whether diabetes is associated with an increased rate of Ub conjugation to muscle ...the N-end rule pathway that involves E2 14k and ...this ...
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N terminomics reveals control of Arabidopsis seed storage proteins and proteases by the Arg/N end rule pathway
... The N-termini of several proteases were downregulated in the prt6 N-terminome, two of which, RD21A and SLP2, were also downregulated at the transcript level ...
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“The N-End Rule Pathway: Its Physiological Importance and Role in Disease Pathology” by Subrata Kumar Pore, Rajkumar Banerjee, India.
... their N-recognin binding efficacies have been examined ...inhibit N- end rule substrate (RGS4) degradation more efficiently in vitro mammalian ...inhibit N-end rule ...
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Genetic interactions between ABA signalling and the Arg/N-end rule pathway during Arabidopsis seedling establishment
... Arg/N-end rule pathway in the seed to seedling transition: regulation of oil bodies and sensitivity to exogenous sugar (summarised in ...the N-end rule pathway and ...
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Biochemical and Genetic Studies of the N-End Rule Pathway in Yeast and Mammals
... made N-terminal cotranslationally, through the (usually) complete removal of the initially present Met residue by ribosome-associated MetAPs ...made N-terminal through a sequence-specific cleavage of a ...
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Studies of the N-end Rule Pathway in Bacteria and Mammals
... Arg/N-end rule pathway in ...of N-end rule substrates. The Arg/N-end rule pathway targets specific unacetylated N-terminal ...Ubr1 ...
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Studies of the N-End Rule Pathway in Saccharomyces cerevisiae
... E3 Ub ligase (Fig. 1A) may physically interact with Ygl081w, Pex7, Yak1, Mgt1, Ccr4, Gal80, and Srs2 [see supporting information (SI) Materials and Methods and the legend to Fig. S1]. We asked whether any of these ...
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Distinct branches of the N end rule pathway modulate the plant immune response
... NTAQ1 function influences defence gene expression and synthesis of camalexin.. demonstrate that downstream responses to NTAQ1, measured as responsive gene.[r] ...
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Development of N-end Rule Ubiquitin Pathway Inhibitors and Hsp-90 Targeted miRNA Delivery System As Novel Anticancer Therapeutics
... stabilizing N-terminal residues (e.g. Met, Val) are not degraded in this pathway and are ...basic N-terminal residues ...hydrophobic N-terminal residues (e.g. Phe, Leu, Ile) are type 2 ...
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Development of Novel Synthetic Bivalent Inhibitors of N-end Rule Ubiquitin Pathway and Sigma Receptor - targeted Anticancer Therapeutics
... Therefore, this study demonstrates the development of a novel synthetic heterovalent inhibitor of N-end rule pathway, which possesses significant antiangiogenic and antiproliferative property ...
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The N end rule and retroviral infection: no effect on integrase
... the N-end rule pathway we decided to examine the role of HIV-1 ...the N-end rule [18,20,21] and it has been a focus for the development of small molecule inhibitors in ...
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Discovery and implementation of a novel pathway for n-butanol production via 2-oxoglutarate
... 2OG pathway requires the carboxylation of one phosphoenolpyruvate molecule to oxaloacetate and the activation of 2-hydroxyglutarate to 2-hydroxyglutaryl- CoA using acetyl-CoA as a ...2OG pathway less ...
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Unique Microbial Catabolic Pathway for the Human Core N Glycan Constituent Fucosyl α 1,6 N Acetylglucosamine Asparagine
... 4-decarboxylase), alfR2 (transcriptional regulator), pepV (peptidase), asnA2 (glycosyl- asparaginase), and sugK (sugar kinase) genes. Knockout mutants showed that alfH, alfC, asdA, asnA2, and sugK are necessary for ...
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Removal of One Nonhomologous DNA End During Gene Conversion by a RAD1- and MSH2-Independent Pathway
... the end of the invading DNA is not homologous to the donor, the nonhomologous sequences must be removed before new synthesis can ...nonhomologous end, repair is reduced on average only ...second end ...
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Adeno-Associated Virus Site-Specific Integration Is Mediated by Proteins of the Nonhomologous End-Joining Pathway
... nonhomologous end joining (NHEJ) or homologous recombination ...likely pathway, because integration is into a region of very limited homology, the fact that there is some homology between the minimal ...
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