N-linked glycosylation
Unconventional N Linked Glycosylation Promotes Trimeric Autotransporter Function in Kingella kingae and Aggregatibacter aphrophilus
... ABSTRACT Glycosylation is a widespread mechanism employed by both eukaryotes and bacteria to increase the functional diver- sity of their ...unconventional N-linked glycosylation of the ...
9
Molecular Determinants of Species Specificity in the Coronavirus Receptor Aminopeptidase N (CD13): Influence of N-Linked Glycosylation
... this N-linked glycosylation sequon converted hAPN into a functional receptor for porcine or feline coronaviruses, we used site-directed mutagenesis to remove this sequon from wild-type hAPN and ...
12
HIV 1 gp120 N linked glycosylation differs between plasma and leukocyte compartments
... of N-linked glycosylation sites in the HIV-1 envelope has been known to facilitate viral evasion from the host immune ...the N-linked glycosylation analysis yields interesting ...
10
Interactions between N linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum
... the N-linked glycosylation pattern of each site in NS beyond the human version of the protein, we reconstructed an evolutionary tree of NS-expressing ...of N- glycosylation patterns for ...
16
Role of N-Linked Glycosylation for Sindbis Virus Infection and Replication in Vertebrate and Invertebrate Systems
... for N-linked glycosylation (E1 positions 139 and 245 [E1-139 and E1-245] and E2 positions 196 and 318 [E2-196 and ...altered glycosylation on virion infectivity, growth in cells of vertebrates ...
8
Selection for Neutralization Resistance of the Simian/Human Immunodeficiency Virus SHIVSF33A Variant In Vivo by Virtue of Sequence Changes in the Extracellular Envelope Glycoprotein That Modify N-Linked Glycosylation
... V3 glycosylation mutations confer neutralization ...V1 N/H, V2 N/S, and V3 NR/YT N-linked glycosylation mutants were first examined to determine whether any of the changes ...
7
N-Linked Glycosylation Protects Gammaretroviruses against Deamination by APOBEC3 Proteins
... multiple N-linked glyco- sylated residues that could be packaged into virions and act as a functional surrogate to gPr80 ...whether N-linked glycosylation of virion-packaged proteins ...
16
Functional Role of N-Linked Glycosylation in Pseudorabies Virus Glycoprotein gH
... predicted N-glycosylation sites in PrV gH are modified by N-glycans, which play a modulating role in proper localization and function of PrV gH during membrane ...by N-glycans is not necessary ...
18
Mutational analysis of the N-linked glycosylation sites of the SU envelope protein of Moloney murine leukemia virus.
... Mutation of one N-linked glycosylation site was lethal to the virus and altered the processing and transport of the precursor protein to the cell surface and virus.. Recently, a similar [r] ...
7
Role of N-Linked Glycosylation of the 5-HT2A Receptor in JC Virus Infection
... five N-linked glycosylation sites ...whether N-linked glycosyla- tion of 5-HT 2A R is required for JCV infection, cells were treated with PNGase F to specifically remove ...
8
N linked glycosylation restricts the function of Short gastrulation to bind and shuttle BMPs
... putative glycosylation sites are conserved It has been known for a long time that Sog is a glycoprotein (Marqués et ...how glycosylation contributes to Sog function has not been ...putative ...
11
N-Linked Glycosylation of West Nile Virus Envelope Proteins Influences Particle Assembly and Infectivity
... the glycosylation sites on prM and E are utilized and suggest that the rate-limiting step of particle assembly is folding and association in the ER (39), while transport and processing through the Golgi network ...
13
The V1V2 Domain and an N-Linked Glycosylation Site in the V3 Loop of the HIV-1 Envelope Glycoprotein Modulate Neutralization Sensitivity to the Human Broadly Neutralizing Antibody 2G12
... The broadly neutralizing human monoclonal antibody 2G12 binds to a carbohydrate-dependent epitope involving three major potential N-linked glycosylation sites (PNGS) of gp120 (N295, N332, and N392). ...
7
N Linked Glycosylation in the Hemagglutinin of Influenza A Viruses
... Since the 1918 influenza A virus (IAV) pandemic, H1N1 viruses have circulated in human populations. The hemagglutinin (HA) of IAV determines viral antigenicity and often undergoes N-linked ...
8
Adaptive antibody diversification through N-linked glycosylation of the immunoglobulin variable region
... acquire N -linked gly- cans, a process conditional on the introduction of consensus amino acid motifs ( N -glycosylation sites) during somatic ...that N-glycosylation sites are ...
6
Role for Calnexin and N-Linked Glycosylation in the Assembly and Secretion of Hepatitis B Virus Middle Envelope Protein Particles
... for glycosylation has remained ...for N glycosylation as a folding device within the ...common N glycan proved to be essential for the secretion of M subviral particles from COS-7 cells and ...
5
DNA sequence of the gene for pseudorabies virus gp50, a glycoprotein without N-linked glycosylation.
... This open reading frame has several features of a glycoprotein sequence, although remarkably it does not contain any amino acid sequences necessary for N-linked carbohydrate addition.. I[r] ...
8
Anti-cancer activity of glucosamine through inhibition of N-linked glycosylation
... After removing the culture medium cells in 6-well plates were washed with 1× PBS and then lysed in the wells with 0.1 ml of RIPA lysis and extraction buffer (25 mM Tris-HCl, 150 mM NaCl, 1% NP-40, 1% Sodium deoxy- ...
10
N-Linked Glycosylation Attenuates H3N2 Influenza Viruses
... and glycosylation of the NA, viruses were created by reverse genetics to be iso- genic in all respects except the potential level of glycosyla- ...potential glycosylation (Table 1; ...potential ...
8
Mutational analysis of N-linked glycosylation sites of Friend murine leukemia virus envelope protein.
... The characterization of glycosylation signal mutations of Friend MuLV env proteins reported here provides a more precise picture of the role of N-linked glycans in envelope protein funct[r] ...
10