N-MYC
The expression of the developmentally regulated proto oncogene Pax 3 is modulated by N Myc
... full-length N-myc ...the N-myc expression vector (NM1–5), the level of N-Myc protein was 2–7-fold higher than that observed in control cells (V1), which were stably transfected ...
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Potential role of the N-MYC downstream-regulated gene family in reprogramming cancer metabolism under hypoxia
... oncogene MYC contributes to such aerobic metabolism by activating the expression of numerous genes essential for glycolysis and mitochondrial ...revise MYC-driven metabolism because the mitochondrial ...
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Inhibition of cathepsin proteases attenuates migration and sensitizes aggressive N-Myc amplified human neuroblastoma cells to doxorubicin
... oncogene N-Myc is reported to occur in more than 20% of patients. While N-Myc amplification status strongly correlates with higher tumour aggression and resistance to treatment, the role of ...
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Developmental expression of the N myc downstream regulated gene (Ndrg) family during Xenopus tropicalis embryogenesis
... ABSTRACT The N-myc downstream regulated gene (Ndrg) family consists of four main members Ndrg1, 2, 3, and 4. The Ndrg genes are involved in many vital biological events including development. However, ...
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Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.
... of N-Myc, includes the MB0 and MBI regions and is conserved in c-Myc ...of N-Myc, including MB0, binds independently to Aurora-A ...
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c- myc and N- myc promote active stem cell metabolism and cycling as architects of the developing brain
... of myc genes in normal cellular biology and their ability to cause cancer when in excess, cells have evolved systems to maintain normal total cumulative myc RNA and Myc protein ...main myc ...
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Nicotine exposure during differentiation causes inhibition of N-myc expression
... Proliferating cells at passage 8, 9, or 13 were scraped from flasks in ice cold PBS/Phosphatase Inhibitors. Cell pellets were lysed in RIPA Buffer supplemented with a Protease Inhibitor Cocktail (Roche). The lysate was ...
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Otx2 is a target of N myc and acts as a suppressor of sensory development in the mammalian cochlea
... of Myc-regulated processes has led to the discovery of a large number of genes controlled by the Myc gene family (Conacci-Sorrell et ...of N-myc remains scarce (Beltran, ...on ...
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N-Myc Interactor Inhibits Prototype Foamy Virus by Sequestering Viral Tas Protein in the Cytoplasm
... Foamy viruses (FVs) are complex retroviruses that establish lifelong persistent infection without evident pathology. However, the roles of cellular factors in FV latency are poorly understood. This study revealed that ...
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Wnt signaling and its downstream target N myc regulate basal progenitors in the developing neocortex
... that N-myc (Mycn – Mouse Genome Informatics) is a pivotal target for Wnt signaling in promoting the proliferation of neocortical ...that N-myc is also responsible for mediating the ability of ...
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N Myc Inhibition: Advances in Neuroblastoma Treatment
... with N-Myc amplification in NBL patients and cell lines. Moreover, N-Myc blockade causes suppression of PD-L1 expression in NBL; suggesting N-Myc-inhibition therapy could restore ...
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N-myc downstream-regulated gene 2 (NDRG2) promoter methylation and expression in pituitary adenoma
... Associations between tumors (including glioblastoma, gastric cancer, colorectal cancer, breast and liver cancers, meningioma, bladder and thyroid cancers) and N-myc downstream-regulated gene 2 (NDRG2) have ...
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INSM1 increases N-myc stability and oncogenesis via a positive- feedback loop in neuroblastoma
... by N-myc in N-myc amplified neuroblastoma ...increasing N-myc ...suppress N-myc phosphorylation (Thr-58) and inhibited degradation of ...Inversely, ...
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N Myc–mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer
... between N-Myc and transcriptional cofac- tors or pioneering factors could explain the observed dynamic binding ...of Myc binding sites on chromatin have consensus E-box motifs and many do not even ...
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Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2
... identified N-Myc as a novel activator selectively upregulating GLS2 (but not GLS1) ...Presumably, N-Myc dependent activation of mitochondrial GLS2 might provide for the increased metabolic and ...
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An Amino Acid of Human Parainfluenza Virus Type 3 Nucleoprotein Is Critical for Template Function and Cytoplasmic Inclusion Body Formation
... 1 N ⌬ C21-40 maintains N-N interaction but is defective in N-P ...of N of ...HPIV3 N and mutants ...tagged N and ...untagged N (D) or P (E) were defined as 100%. ...
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Neuroblastoma Represents Distinct Clinical-Biologic Entities: A Review and Perspective From the Quebec Neuroblastoma Screening Project
... Clinical relevance of tumor cell ploidy and N-myc gene amplification in childhood neuroblastoma: a. pediatric oncology group study[r] ...
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Identification of Two Functional Domains within the Arenavirus Nucleoprotein
... of N in N-Z interaction and VLP ...to N-N ...TCRV N protein, was predicted to form an ␣ -helical coiled-coil structure by using the algorithm of Lupas et ...TCRV N-myc and ...
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myc family oncogene amplification in tumor cell lines established from small cell lung cancer patients and its relationship to clinical status and course
... 3 N-myc, and 3 L-myc) cell lines (44%) established from relapsed patients' tumors (P = ...that myc family DNA amplification is more common in tumor cell lines established from treated than ...
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A moving target: structure and disorder in pursuit of Myc inhibitors
... While Myc polypeptides alone are intrinsically disordered, and are likely to exist in multiple conformation states simultaneously, there are transient secondary structure elements that, in some cases, become ...
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