N-myc downstream regulated gene
Developmental expression of the N myc downstream regulated gene (Ndrg) family during Xenopus tropicalis embryogenesis
... The N-myc downstream regulated gene (Ndrg) family consists of four main members Ndrg1, 2, 3, and ...this gene family during vertebrate embryogenesis remain largely ...
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N-myc downstream-regulated gene 1 inhibits the proliferation of colorectal cancer through emulative antagonizing NEDD4-mediated ubiquitylation of p21
... N-myc downstream regulated gene-1 (NDRG1), a mem- ber of the NDRG gene family, is pervasively expressed in epithelial tissues and is a cytoplasmic and nuclear protein ...
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Potential role of the N-MYC downstream-regulated gene family in reprogramming cancer metabolism under hypoxia
... oncogene MYC contributes to such aerobic metabolism by activating the expression of numerous genes essential for glycolysis and mitochondrial ...revise MYC-driven metabolism because the mitochondrial ...
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N myc Downstream Regulated Gene 1 Increases Differentiation Factors Level in Human Prostate Cancer Cells without Affecting Cell Proliferation and Cell Cycle Profiles
... N-myc downstream regulated gene 1 (NDRG1), also known as differentiation related gene 1, was previously identified as an up-regulated gene upon cellular ...up ...
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N-Myc Downstream-Regulated Gene 1 Restricts Hepatitis C Virus Propagation by Regulating Lipid Droplet Biogenesis and Viral Assembly
... identified N-Myc downstream- regulated gene 1 (NDRG1) as a potential antiviral gene since silencing of its expression increased HCV ...
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Original Article N-myc downstream-regulated gene 2 is related to insulin resistance through IL-6/STAT3 pathways in type 2 diabetic mice
... N-myc downstream regulated gene 2 (Ndrg2), a member of the Ndrg gene family, is related to stress response, cellular development, and dif- ferentiation ...
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N-myc downstream-regulated gene 2 (NDRG2) promoter methylation and expression in pituitary adenoma
... Associations between tumors (including glioblastoma, gastric cancer, colorectal cancer, breast and liver cancers, meningioma, bladder and thyroid cancers) and N-myc downstream-regulated ...
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Combined aberrant expression of N-Myc downstream-regulated gene 2 and CD24 is associated with disease-free survival and overall survival in patients with hepatocellular carcinoma
... N-myc downstream-regulated gene 2 (NDRG2) belongs to the NDRG family containing four members, NDRG1, NDRG2, NDRG3 and NDRG4, the amino acid sequence homology among which is 57-65%, ...
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N myc downstream regulated gene 2 expression is associated with glucose transport and correlated with prognosis in breast carcinoma
... are regulated by NDRG2, GLUT1/2/3/4 protein levels were measured in SK-BR-3 cells infected with Ad-NDRG2 or T-47D cells transfected with NDRG2 siRNA in a high-glucose ...
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The expression of the developmentally regulated proto oncogene Pax 3 is modulated by N Myc
... The Myc-Max-Mad network of transcriptional regulators has been shown to modulate gene expression through a subset of E box motifs, which have the core consensus sequence CACGTG (9, ...the Myc ...
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Pharmacological targeting of MYC regulated IRE1/XBP1 pathway suppresses MYC driven breast cancer
... IHC: MYC (1:300, catalog ab32072, Abcam), IRE1 (1:200, catalog 3294, Cell Signaling Technology), BrdU (1:250, catalog ab6326, Abcam), CD31 (1:50, catalog ab28364, Abcam), and cleaved caspase-3 (1:200, catalog ...
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MicroRNAs in the Occurrence and Development of Primary Hepatocellular Carcinoma
... Hepatocellular carcinoma is one of the deadliest types of cancer. Despite improvements in treatment over the past few decades, patient survival remains poor and there is an urgent need for development of targeted ...
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POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia
... The principal analysis was conducted with the murine 430 array, with selected results identified using the U74A+B array set added. All listed transcripts showed increased expression (change p < 0.005) in two ...
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High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N myc gene amplification
... the N-myc gene, tumors from patients with stages III and IV had statistically significantly higher levels of p19/nm23 than tumors from patients with stages I and ...
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Identification of Jun loss promotes resistance to histone deacetylase inhibitor entinostat through Myc signaling in luminal breast cancer
... two gene lists using 817 TCGA breast cancer samples, then defined “signatures” as any gene set that contained a minimum of 10 genes and a Pearson node correlation of greater than ...downregulated ...
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Bortezomib inhibits Burkitt’s lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression
... the transcriptional level, hnRNP K can bind to the poly(C) region of promoters of genes including c-Src, eIF4E, and c-Myc [37, 38]. In addition, hnRNP K can increase FLIP expression by binding to the poly(C) ...
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Deciphering c MYC regulated genes in two distinct tissues
... Igf1- regulated tumour survival through degradation of the Igf binding protein Igfbp3 in ...for MYC activation [90] was for the brain and skin protease gene Bssp1, also known as Kallikrein 6 ...This ...
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Identification of an Upstream Sequence Element Required for Vesicular Stomatitis Virus mRNA Transcription
... that annealed to mRNA2 and would detect initiation events at GS2 as well as those within the extended IGR that had read through the mutated gene end sequence present in the pU6(GE) replicon (Fig. 1B). The major ...
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Gene N Proximal and Distal RNA Motifs Regulate Coronavirus Nucleocapsid mRNA Transcription
... and N protein expression could be affected in these mutants, the analysis of N gene transcription was performed in BHK cells expressing the N protein in trans (BHK-N) (1), to exclude ...
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Roles of MYC-targeting long non-coding RNA MINCR in cell cycle regulation and apoptosis in non-small cell lung Cancer
... siRNA (si-NC) were purchased from Shanghai Gene Pharma Company (China). The siRNA sequences used were as follows: si-MINCR-01 (forward: 5′-GAGCCU UGUUUGCCAUUAATT-3′; reverse: 5′-UUAAUG GCAAACAAGGCUCTT-3′), ...
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