N-Terminal deletion
The Expression of N-Terminal Deletion DNA Pilot Proteins Inhibits the Early Stages of φX174 Replication
... The ⌬ H proteins inhibit early stages of DNA synthesis, which does not require de novo H protein synthesis. There are several mechanisms by which the H protein could lead to elevations in viral protein synthesis. It ...
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Antigenicity and Immunogenicity of RV144 Vaccine AIDSVAX Clade E Envelope Immunogen Is Enhanced by a gp120 N-Terminal Deletion
... and N-terminal 11-aa deletion (gD ⌬ 11 gp120), or with only the 11-aa deletion ( ⌬ 11 gp120) are ...without N-terminal deletion and included the clade B Env MN, 63521, and ...
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N-terminal deletion in the src gene of Rous sarcoma virus results in synthesis of a 45,000-Mr protein with mitogenic activity.
... 8 0022-538X/87/082523-07$02.00/0 Copyright © 1987, American Society for Microbiology N-Terminal Deletion in the src Gene of Rous Sarcoma Virus Results in Synthesis of a 45,000Mr Protein [r] ...
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Nuclear localized Influenza nucleoprotein N terminal deletion mutant is deficient in functional vRNP formation
... of N-terminal NP interactions inside the host cell, we set out to construct a plasmid encoding an N-terminal NP deletion mutant able to localize to the nucleus, where viral RNA ...
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Origin of Expression of the Herpes Simplex Virus Type 1 Protein US1.5
... N-terminal deletion mutants of ICP22 with those of bands detected in pAlter22-transfected, d22:GFP-infected ...of N-terminal ICP22 deletion mutants was constructed by PCR and ...
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Identification of Amino Acid Residues Critical for the Anti-Interferon Activity of the Nucleoprotein of the Prototypic Arenavirus Lymphocytic Choriomeningitis Virus
... The N-terminal 350 amino acid residues of LCMV NP are not required to counteract the IFN-I ...NP N-terminal deletion ...NP N-terminal ...⌬ N mutants containing a ...
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Dissecting the Role of the N-Terminal Domain of Human Immunodeficiency Virus Integrase bytrans-Complementation Analysis
... an N-terminal domain is mixed with an IN from which the com- plete N-terminal domain has been removed, since no oli- gomerization can happen between the two mutant ...the ...
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Rgc2 Regulator of Glycerol Channel Fps1 Functions as a Homo- and Heterodimer with Rgc1
... The N-terminal domain of Rgc2 is important for self-association and ...its N-terminal domain, a pleckstrin homology (PH) domain deletion and a C-terminal ...domain ...
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Divergent Subunit Interactions among Fungal mRNA 5′-Capping Machineries
... four N-terminal deletion mutants of CaCet1 for the ability to support viability of a ⌬ceg1 ⌬cet1 strain when combined with either Ceg1 or Cgt1 ...
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Apparent uncoupling of oncogenicity from fibroblast transformation and apoptosis in a mutant myc gene transduced by feline leukemia virus.
... large N-terminal deletion in T17 v-myc is the most likely source of its fibroblast transformation defect, since the dele- tion overlaps with a number of engineered deletion mutations which ...
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Identification of Sequences in Brome Mosaic Virus Replicase Protein 1a That Mediate Association with Endoplasmic Reticulum Membranes
... 1a deletion derivatives retaining region DE, including CDE-, DEF-, and DE-GFP ...their deletion derivatives in the absence of other viral proteins (46, 50, ...
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The transcriptional cofactor MIER1 beta negatively regulates histone acetyltransferase activity of the CREB binding protein
... Background: Mier1 encodes a novel transcriptional regulator and was originally isolated as a fibroblast growth factor early response gene. Two major protein isoforms have been identified, MIER1α and β, which differ in ...
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Investigating the functionality of a ribosome binding mutant of NAA15 using Saccharomyces cerevisiae
... Objective: N-terminal acetylation is a common protein modification that occurs preferentially co-translationally as the substrate N-terminus is emerging from the ...major N-terminal ...
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The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding.
... Deletion mutagenesis has shown that both the N- and C-terminal regions of the protein are required for 3' processing and DNA strand transfer 7, 29, 35, whereas a core domain that lacks t[r] ...
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Deletion of a 197-Amino-Acid Region in the N-Terminal Domain of Spike Protein Attenuates Porcine Epidemic Diarrhea Virus in Piglets
... the deletion of domain 0 may influence two nonneutralizing B cell epitopes, SS2 and SS6 (48), which may contribute to the conformational change of the S2 subunit during the virus-cell membrane fusion ...the ...
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A large deletion in the matrix domain of the human immunodeficiency virus gag gene redirects virus particle assembly from the plasma membrane to the endoplasmic reticulum.
... To analyze the importance of the N-terminal MA domain of the HIV-1 Gag and Gag-Pol polyproteins for protein transport, particle assembly, and release, we created an in-frame deletion mut[r] ...
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vRel is an inactive member of the Rel family of transcriptional activating proteins.
... Full-length chicken cRel, mouse cRel, and Dorsal fusion proteins all activated transcription weakly; however, deletion of N-terminal Rel sequences from each of these proto-oncogene encod[r] ...
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Positively Charged Termini of the L2 Minor Capsid Protein Are Necessary for Papillomavirus Infection
... two additional mutants were generated. One encoded the N- terminal amino acids in scrambled form (L2mix2–9, which replaces MSARKRVKR with MRVKSKRAR). The other en- coded the 9 C-terminal amino acids ...
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Functional Interaction between the pp71 Protein of Human Cytomegalovirus and the PML-Interacting Protein Human Daxx
... pp71 deletion mutants in the context of the GAL4 DNA-binding domain was constructed and tested for hDaxx binding by using the yeast two-hybrid system ...ultimate N- or C-terminal amino acids ...
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Golgi Network Targeting and Plasma Membrane Internalization Signals in Vaccinia Virus B5R Envelope Protein
... The outer membrane of extracellular vaccinia virus particles is derived from the TGN or endosomal cisternae that have been modified by the insertion of specific viral proteins. The type I integral membrane protein ...
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