N-terminal heptad repeat
Mutations of Gln64 in the HIV-1 gp41 N-Terminal Heptad Repeat Render Viruses Resistant to Peptide HIV Fusion Inhibitors Targeting the gp41 Pocket
... gp41 N-terminal heptad repeat (NHR), we constructed pseudoviruses by replacement of Q64 in the gp41 pocket region with Ala (Q64A) or Leu ...
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Mutations of Glu560 within HIV 1 Envelope Glycoprotein N terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry
... to N‑ and C‑terminal heptad repeat regions (HR1 and HR2, respectively) of gp41 can inhibit HIV‑1 infection in a dominant negative manner by interfering with refolding of the viral HR1 and HR2 ...
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Conserved Leucines in N-Terminal Heptad Repeat HR1 of Envelope Fusion Protein F of Group II Nucleopolyhedroviruses Are Important for Correct Processing and Essential for Fusogenicity
... truncated N-linked glycosylation pathway and hence a paucimannose type of N-linked glycans, which are frequently identified in mature glycoprotein expressed in insect cells ...large N-linked glycans ...
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Inhibition of Murine Leukemia Virus Envelope Protein (Env) Processing by Intracellular Expression of the Env N-Terminal Heptad Repeat Region
... an N-terminal, alpha- helical, trimerization domain and a C-terminal region that refolds during fusion to bind the N-helix ...the N and C regions is believed to pull viral and target ...
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Conserved Salt Bridge between the N- and C-Terminal Heptad Repeat Regions of the Human Immunodeficiency Virus Type 1 gp41 Core Structure Is Critical for Virus Entry and Inhibition
... an N-terminal heptad repeat (NHR) (also called HR1), a C-terminal heptad repeat (CHR) (also called HR2), and a tryptophan-rich ...
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Heptad Repeat 2-Based Peptides Inhibit Avian Sarcoma and Leukosis Virus Subgroup A Infection and Identify a Fusion Intermediate
... distinct heptad repeat domains within the transmembrane ...two heptad repeat domains of the avian sarcoma and leukosis virus subgroup A (ASLV-A) TM subunit of the envelope protein were ...
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Nonneutralizing Antibodies Induced by the HIV-1 gp41 NHR Domain Gain Neutralizing Activity in the Presence of the HIV Fusion Inhibitor Enfuvirtide: a Potential Therapeutic Vaccine Strategy
... gp41 N-terminal heptad repeat (NHR) domain (N63) exhibit potent and broad neutralizing activity against laboratory-adapted HIV-1 strains, including the drug-resis- tant variants, and primary ...
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Common principles and intermediates of viral protein mediated fusion: the HIV 1 paradigm
... central N-terminal trimeric coiled coil (or heptad repeat 1, HR1 domain) and three peripheral C-terminal helices (HR2 domains), as depicted in ...C- terminal and ...
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Peptides Trap the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Fusion Intermediate at Two Sites
... two heptad repeat motifs (HR) in the ectodomain of gp41 self-assemble into a trimer-of-hairpins (3, 7, 17, 24, ...The N-terminal HR (N-HR) folds into a parallel, trimeric coiled-coil ...
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Oligomerization of the hydrophobic heptad repeat of gp41.
... hydrophobic heptad repeat of gp41 to direct protein oligomerization, we have cloned this region of HIV-1 gp41 into the bacterial expression vector pRIT2T, a plasmid which encodes the ...
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Six helix bundle completion in the distal C terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection
... Background: The native pre‑fusion structure of gp120/gp41 complex of human immunodeficiency virus type 1 was recently revealed. In the model, the helices of gp41 (α6, α7, α8, and α9) form a four‑helix collar underneath ...
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A hydrophobic heptad repeat of the core protein of woodchuck hepatitis virus is required for capsid assembly.
... The N terminus of the core protein is thought not to be exposed on the surface of the capsid particle and probably is buried within the structure to form a bond that promotes the protein-protein interaction (4, ...
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The C Terminus of the B5 Receptor for Herpes Simplex Virus Contains a Functional Region Important for Infection
... Sutter, N. McLaren, and A. Oveta Fuller, J. Virol. 79:7419–7430, 2005). Heptad repeats found in the B5 C terminus are predicted to form an ␣ -helix for coiled coil ...the heptad repeat motif ...
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Mutational Analysis of Residues in the Coiled-Coil Domain of Human Immunodeficiency Virus Type 1 Transmembrane Protein gp41
... the heptad repeat) near the fusion peptide of gp41 that potentially affect both the stability of the coiled- coil core itself and the interactions with the external antipar- allel helices (see ...the ...
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Bovine leukemia virus long terminal repeat variability: identification of single nucleotide polymorphisms in regulatory sequences
... Whole BLV genome is flanked at both 5′ and 3′ ends by long terminal repeat (LTR) sequences [4, 5]. Each LTR is composed of three regions called U3, R and U5. U3 plays a crucial role in the induction of BLV ...
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Model of trigger mechanisms of SARS CoV-2 infections
... contains the main protein segments that facilitate virus- cell fusion, including the fusion peptide (FP), two heptad- repeat regions (HR1 and HR2), transmembrane domain (TM[r] ...
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Structure of the reovirus cell-attachment protein: a model for the domain organization of sigma 1.
... A region in the middle of the T1L, T2J, and T3D oi amino acid sequences in which conserved apolar residues conform to alternating repeat patterns: heptad repeats followed by alternating [r] ...
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A Heptad Repeat in Herpes Simplex Virus 1 gH, Located Downstream of the α-Helix with Attributes of a Fusion Peptide, Is Critical for Virus Entry and Fusion
... (iii) A 25-residue peptide corresponding to HR-1 inhibited HSV-1 infection in a dose-dependent manner. The peptide was effective only if present at the time of virus entry into the cell; it was ineffective if present ...
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Residues in the Heptad Repeat A Region of the Fusion Protein Modulate the Virulence of Sendai Virus in Mice
... shorter N-P UTR has been shown to increase F protein ex- pression, virus replication, cell-cell fusion, and F protein in- corporation into virions while simultaneously decreasing pathogenicity in ferrets ...
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Spring-Loaded Heptad Repeat Residues Regulate the Expression and Activation of Paramyxovirus Fusion Protein
... three N-linked glycosylation sites that are utilized (N104, N245, and N449) ...cleaves N-linked oligosaccharides of the high-mannose form after they are synthesized in the endoplas- mic ...
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