N-terminal kinase
Varicella-Zoster Virus Infection of Human Fibroblast Cells Activates the c-Jun N-Terminal Kinase Pathway
... (MAP kinase kinase kinase; usually a serine/threonine-specific kinase), which next activate MAP2Ks (S/T and tyrosine dual specific kinase), which then activate MAPKs by phosphoryla- ...
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Activation of cJUN N-Terminal Kinase by Herpes Simplex Virus Type 1 Enhances Viral Replication
... two terminal kinases, cJUN N-terminal kinase (JNK) and p38, of stress-activated signal transduction kinase ...solid-phase kinase assay, a phospho- specific antibody, and extracts ...
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Anti-high mobility group box-1 (HMGB1) antibody attenuates kidney damage following experimental crush injury and the possible role of the tumor necrosis factor-α and c-Jun N-terminal kinase pathway
... Previous studies have demonstrated that HMGB1 could increase the production of TNF-α indirectly [13] and also increase the level of c-Jun N-terminal kinase (JNK), known as stress-activated protein ...
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c Jun N terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
... protein kinase (MAPK) likely plays a critical role in the pathogenesis of rheumatoid arthritis (RA), which is a chronic inflammatory dis- ease marked by cytokine production, synovial lining hyperplasia, and joint ...
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Human Endotoxemia Activates p38 MAP Kinase and p42/44 MAP Kinase, But Not c-Jun N-terminal Kinase
... Protein Kinase (MAPK) family are critically involved in intracellular signal trans- duction, mediating cell responses to a variety of dif- ferent infectious and inflammatory ...c-jun N-terminal ...
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Original Article The C-jun N-terminal kinase signaling pathway regulates cyclin D1 and cell cycle progression in airway smooth muscle cell proliferation
... C-jun N-terminal kinase; NF-κB, Nuclear factor-kappa B; PI3K, Phosphoinosi- tide 3 kinase; ERK, Extracellular signal-regulat- ed kinase; MAPK, Mitogen activated protein kinase; ...
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Inhibition of c Jun N terminal kinase (JNK) suppresses porcine oocyte ageing in vitro
... ABSTRACT: Oocyte ageing is a complex of processes that occur when matured in vitro oocytes are, after rea- ching the metaphase II stage, exposed to further in vitro culture. Aged oocytes remaining at the metaphase II ...
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Genetic Analysis of Slipper/Mixed Lineage Kinase Reveals Requirements in Multiple Jun-N-Terminal Kinase-Dependent Morphogenetic Events During Drosophila Development
... Jun-N-terminal kinase ( JNK) kinase kinases to transduce ex- tracellular signals during development and homeostasis in ...JNK kinase ( JNKK/MKK7) substrate for SLPR, suggesting that the ...
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c Jun N terminal kinase activation by nitrobenzoxadiazoles leads to late stage autophagy inhibition
... c-Jun N-terminal kinase (JNK) [2, 3, 13, ...signal-regulating kinase (ASK1), which in turn activates both p38 and JNK mito- gen-activated protein kinase (MAPK) signaling pathways [3, ...
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In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells
... Background: The c-Jun N-terminal kinase (JNK) signaling pathway plays an important role in neuronal pathophysiology. Using JNK inhibitors, we examined involvement of the JNK pathway in cultured rat ...
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The Influenza A Virus NS1 Protein Inhibits Activation of Jun N-Terminal Kinase and AP-1 Transcription Factors
... Jun N- terminal kinase (JNK) (also termed stress-activated protein kinase [SAPK]), which in turn phosphorylates and thereby upregulates the activity of transcription factors of the AP-1 family ...
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Jun N terminal kinase maintains tissue integrity during cell rearrangement in the gut
... Jun N-terminal kinase (JNK) is also required for tissue elongation, but the precise cellular role of JNK in this context has remained ...Rho kinase is necessary to induce cell intercalation ...
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Role of Jun N terminal Kinase (JNK) signaling in the wound healing and regeneration of a Drosophila melanogaster wing imaginal disc
... ABSTRACT When a fragment of a Drosophila imaginal disc is cultured in growth permissive conditions, it either regenerates the missing structures or duplicates the pattern present in the fragment. This kind of pattern ...
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c Jun N terminal kinase activity supports multiple phases of 3D mammary epithelial acinus formation
... c-Jun N-terminal kinase (JNK) activity for acinus ...regulated kinase (ERK) phosphorylation, cell proliferation, adhesion-independent cell survival and expression of epithelial-mesenchymal ...
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Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
... Figure 7 Inhibition of pJNK improves the structural and functional deficits caused by inhibition of USP14 ’ s DUB activity. (A) Representative immunoblots of pJNK1/2 and JNK1/2 in spinal cords from 5-week-old wild type ...
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Knockout of the c-Jun N-terminal Kinase 2 aggravates the development of mild chronic dextran sulfate sodium colitis independently of expression of intestinal cytokines TNFα, TGFB1, and IL-6
... The DSS concentration of 1% for induction of mild chronic colitis was determined in previous studies (data not shown) and is suitable for experimental protocols. The JNK1 knock- out mice (Mapk8–/–) and JNK2 knockout mice ...
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Protective effect of DA-9401 in finasteride-induced apoptosis in rat testis: inositol requiring kinase 1 and c-Jun N-terminal kinase pathway
... transmembrane kinase/endoribonuclease 1 (p-IRE1), p-JNK, procaspase-3 and cleaved caspase-3 measurements in testis tissue were conducted with tissue that had been washed with cold phosphate-buffered saline ...
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Regulation of inflammatory arthritis by the upstream kinase mitogen activated protein kinase kinase 7 in the c Jun N Terminal kinase pathway
... Cytokine-induced JNK activation is dependent on MKK7 in cultured FLS and does not require MKK4. To determine the effect of selective MKK7 deficiency on JNK signaling in vivo , the ankle joints were evaluated by Western ...
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C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
... While some recent studies have reported a possible association between TDP-43 and TIA-1 [16,17], these have been demonstrated with transfected cells and no clear evidence of endogenous TDP-43-TIA-1 interaction was ...
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MEKK1, JNK, and SMAD3 mediate CXCL12-stimulated connective tissue growth factor expression in human lung fibroblasts
... protein kinase (MAPK), which subsequently induce sev- eral cellular responses including gene expression and pulmonary fibrosis [14, ...c-Jun N-terminal kinase (JNK) signaling pathway ...
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