Na+/H+ exchange
Endothelin stimulates phospholipase C, Na+/H+ exchange, c fos expression, and mitogenesis in rat mesangial cells
... activated Na+/H+ exchange, causing cytosolic alkalinization, and enhanced transcription of the c-fos protooncogene, additional biochemical signals closely linked to ...
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H+/solute induced intracellular acidification leads to selective activation of apical Na+/H+ exchange in human intestinal epithelial cells
... uted throughout the human small intestine and colon (20). Immunohistochemical studies demonstrate that both human NHE2 and NHE3 are localized at the api- cal membrane of human intestinal tissues (28). Broad- ly speaking, ...
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Hyposmolality stimulates apical membrane Na+/H+ exchange and HCO3– absorption in renal thick ascending limb
... membrane Na + /H + exchange and provide the first evidence that NHE3 is regulated by hyposmotic ...apical Na + /H + exchange activity in renal cells by a decrease in osmolality ...
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Effect of acute changes in glomerular filtration rate on Na+/H+ exchange in rat renal cortex
... on Na+/H+ exchange activity in renal brush border membrane vesicles ...of H+ gradient-driven 22Na+ uptake in each animal ...three Na+ concentration gradients to allow calculation of ...
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Effect of in vitro metabolic acidosis on luminal Na+/H+ exchange and basolateral Na+:HCO3 cotransport in rabbit kidney proximal tubules
... The aim of this study was to evaluate the role of the kidney in mediating the signals involved in adaptive changes in luminal Na+/H+ exchange and basolateral Na+:HCO3- cotransport systems in ...
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Differences in proton pumping and Na/H exchange at the leaf cell tonoplast between a halophyte and a glycophyte
... investigated Na + /H + -exchange activity in tono- plast membrane vesicles derived from shoots of ...the Na + – H + exchange, as observed in ...tonoplast Na + /H + ...
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Na+/H+ exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis?
... Independent of phosphorylation by protein kinases and phos- phatases, NHE1 interaction with its cofactors and binding partners is also important in its regulation, particularly in response to cell stressors and external ...
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Ursodeoxycholate stimulates Na+ H+ exchange in rat liver basolateral plasma membrane vesicles
... chenodeoxycholate, or deoxycholate (200 microM) had no effect on pH-driven Na+ uptake. UDCA (200 microM) had no effect on either membrane lipid fluidity, assessed by steady- state fluorescence polarization using ...
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Sodium uptake across basolateral membrane of rat distal colon Evidence for Na H exchange and Na anion cotransport
... of Na transport across basolateral membrane vesicles of rat distal ...increasing Na concentration: the apparent kinetic constants (Km) for Na for the DIDS- insensitive component of proton ...
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Spontaneously hypertensive rat vascular smooth muscle cells in culture exhibit increased growth and Na+/H+ exchange
... Because Na+/H+ exchange, which we have previously demonstrated in cultured VSMC, plays an essential role in mediating growth factor responses, we hypothesized ...
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ACTIVATION AND PHYSIOLOGICAL ROLE OF Na+/H+ EXCHANGE IN LAMPREY (LAMPETRA FLUVIATILIS) ERYTHROCYTES
... In conclusion, although sodium transport across the lamprey red cell membrane is activated by various treatments, in physiological conditions large net sodium and proton movements only occur in response to internal acid ...
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RAPID RESPIRATORY CHANGES IN TROUT RED BLOOD CELLS DURING Na+/H+ EXCHANGE ACTIVATION
... These observations apply to blood flowing in a closed system. In vivo, the blood arriving at the gills is flowing in a closed system prior to entering the lamellar circuit and, indeed, catecholamine levels are initially ...
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Na+/H+ exchange and osmotic shrinkage in isolated trout hepatocytes
... In fish, changes in physiological state, levels of exercise and environment disturb the acid–base balance of the animal, affecting both extracellular and intracellular pH. Salmonids in particular (such as the rainbow ...
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Inhibition of Na/H exchange in avian intestine by atrial natriuretic factor
... with H-8, an inhibitor of cyclic nucleotide-dependent protein ...with H-8 or the calmodulin inhibitor, calmidazolium (CM), prevented the effects of 8-Br-cGMP and APIII on ...amiloride-sensitive ...
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Na+/H+ exchange in human lymphocytes and platelets in chronic and subacute metabolic acidosis
... (Na+/H+) exchange has been examined in animal models; however, few data are available from human ...on Na+/H+ exchange in man, as well as to examine the relationship between ...
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Signalling pathways involved in hypertonicity and acidification induced activation of Na+/H+ exchange in trout hepatocytes
... Experimental animal and hepatocytes isolation Rainbow trout (Oncorhynchus mykiss Walbaum) were obtained from a local hatchery and were acclimated in 200·l aquaria with running water at 15°C. Fish were fed daily with ...
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Adaptation of Na+ H+ exchange in renal microvillus membrane vesicles Role of dietary protein and uninephrectomy
... studied Na+ transport in rat microvillus membrane vesicles isolated from uninephrectomized or sham operated rats fed 6% (low), 24% (standard), or 40% (high) protein ...vesicular Na+ transport was greater in ...
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Adrenalin Induced Na+/H+ Exchange in' Trout Erythrocytes and its Effects Upon Oxygen Carrying Capacity
... Addition of adrenalin 10~ 4 moll~ 1 to trout erythrocytes in an unbuffered saline resulted in a rapid acidification of the extracellular medium.. This process was inhibited by amiloride[r] ...
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Potassium depletion increases luminal Na+/H+ exchange and basolateral Na+:CO3=:HCO3 cotransport in rat renal cortex
... in Na+ influx in the KD group was DIDS sensitive, suggesting that Na+:CO3=:HCO3- cotransport accounted for the observed ...of Na+ influx showed a Km of ...in Na+ influx in the KD ...
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Genetic and physiological association of diabetes susceptibility with raised Na+/H+ exchange activity
... To identify further susceptibility genes, diabetic backcross mice, produced after crossing NOD/Lt to the nondiabetic strains SJL and C57BL/6 B6, were examined for markers not previously [r] ...
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