NAC, N-acetylcysteine
N acetylcysteine (NAC) in schizophrenia resistant to clozapine: a double blind randomised placebo controlled trial targeting negative symptoms
... Clozapine is the most effective antipsychotic drug for treatment–resistant SZ. Due to the significant adverse event profile, it is generally only prescribed to those who have not responded to other antipsychotics and is ...
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Protective role of N-acetylcysteine (NAC) on human sperm exposed to etoposide
... that NAC seems to be more efficient in attenuating sperm etoposide cytotoxic effects instead of being used as a chemoprophylactic agent, which reinforces the idea that there might be a new NAC mechanism ...
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Effects of N-acetylcysteine (NAC) supplementation in resuscitation fluids on renal microcirculatory oxygenation, inflammation, and function in a rat model of endotoxemia
... of NAC on regional blood flow and cardiac output [19, 33 – 37]. First, NAC administration was shown to improve survival in experimental models of peritonitis-induced sepsis [38, ...of NAC ...
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N-acetylcysteine in COPD: why, how, and when?
... of N-acetylcysTeine High dose in Exacerbations of chronic Obstructive pulmoNary disease [PANTHEON] study) [120], where high-dose NAC or placebo were administered for one year, in addition to existing ...
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Therapeutic effects of N-acetylcysteine against malathion-induced hepatotoxicity
... Myeloperoxidase; NAC: N -Acetylcysteine; PCR: Polymerase chain reaction; RNA: Ribonucleic acid; ROS: Reactive oxygen species; RT-PCR: Reverse transcription polymerase chain ...
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Advanced glycation end products increase retinal vascular endothelial growth factor expression
... Abbreviations used in this paper: AGE, advanced glycation end product; BCE, bovine capillary endothelial; DMTU, N,N9-dimethylthiourea; NAC, N-acetylcysteine; nt, nucleotides; ROI, reacti[r] ...
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Caffeic acid phenethyl ester modulates Helicobacter pylori induced nuclear factor kappa B and activator protein 1 expression in gastric epithelial cells
... pylori; NF-kB; AP-1; COX-2; gastric epithelial cells AP-1, activator protein-1; CAPE, caffeic acid phenethyl ester; NAC, N-acetylcysteine; NF-kB, nuclear factorkappa B; PMA, phorbol 12-m[r] ...
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N-acetylcysteine overdose after acetaminophen poisoning
... recognized in our patient, who presented to the emergency ward after taking 16.25 g of acetaminophen in an attempt to commit suicide. She was complaining of peptic stomach pain, dizziness, and headache. Her serum ...
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ANTI ATHEROSCLEROTIC POTENTIAL OF PIOGLITAZONE AND N ACETYLCYSTEINE
... plaque. N- acetylcysteine (NAC) stimulates GSH (glutathione) formation and thus helps in scavenging ...and N-acetylcysteine in ...pioglitazone, N-acetylcysteine and their ...
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ROLE OF N ACETYLCYSTEINE IN RESCUE OF MICE HEART
... patients. NAC treatment reduces oxidative damage and is favorable therapy to DMD patients with heart failure 26 ...4. NAC and cell signaling in heart cells: ROS ...
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N -acetylcysteine negatively regulates Notch3 and its malignant signaling
... of NAC may determine how it functions in ...that NAC at a concentration of ...because NAC has no impact on Notch3 levels at 2 mM but displays an inhibitory role in malignancy at 5-10 ...of NAC ...
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N-acetylcysteine as a chemoprotectant against ifosfamide nephrotoxicity; from mechanism to prevention
... of NAC for this population is imperative before its clinical use as a renal ...of NAC in renal protection during IFO ...of NAC in protecting against IFO-induced cytotoxicity and glutathione depletion ...
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AVERTING CANCER EFFECT OF PARACETAMOL AND PHENACETIN BY N ACETYLCYSTEINE AND ITS ANALOGUES
... From Table 10, it is obvious that the studied molecules (NAC, NAM, and NAGA) and their free radicals, Fig. 11, have small comparative Ea and Ip values with respect to those of nucleic acid bases, therefore, there ...
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N-acetylcysteine versus progesterone on the cisplatin-induced peripheral neurotoxicity
... the NAC and progesterone-treated groups were significantly ...the NAC seems to be supe- rior on that of the progesterone as the NF-kB in the progesterone-treated group was 62% higher than that of the ...
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The neuroprotective effect of N-acetylcysteine in spinal cord-injured rats
... of NAC application in SCI in an animal model were observed in the present ...the NAC group than in the control ...with NAC in comparison to the control ...
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Dilution of Intravenous N -Acetylcysteine as a Cause of Hyponatremia
... diluent for the initial infusion when the body weight is less than 40 kg. For example, a child weighing 10 to 15 kg would have a loading dose in 11.25 mL of 20% NAC in 40 mL of 5% dextrose. However, the diluent ...
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Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis
... of NAC, we were able to demonstrate that NAC is able to reduce the risk of exacerbations, although this protective effect was more apparent in patients without a diagnosis of COPD made using spirometric ...
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Low molecular weight S nitrosothiols and blood vessel injury
... antioxidant N-acetylcysteine (NAC) induces pulmonary arterial hypertension in ...chronic NAC therapy may induce similar vascular pathology in ...
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N acetylcysteine inhibits muscle fatigue in humans
... decreases contractile function of unfatigued muscle in a dose-dependent manner. The present experiments test the hypothesis that NAC pretreatment can inhibit acute muscular fatigue in humans. Healthy volunteers ...
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Reactive oxygen species mediate soft corals-derived sinuleptolide-induced antiproliferation and DNA damage in oral cancer cells
... Abstract: We previously reported that the soft coral-derived bioactive substance, sinuleptolide, can inhibit the proliferation of oral cancer cells in association with oxidative stress. The functional role of oxidative ...
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