NALP3 inflammasome
The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation
... of inflammasome activation is the efflux of K + and the possible influx of small danger-associated or pathogen-associated molecular patterns ...for inflammasome activation stimulated by neurotoxic prion ...
10
A role for uric acid and the nalp3 inflammasome in antiphospholipid antibody induced IL 1β production by human first trimester trophoblast
... the Nalp3 inflammasome which, in addition to the Nod-like receptor, Nalp3 (Nlrp3), contains apoptosis-associated speck-like protein containing a CARD (ASC) and caspase-1 ...the inflammasome ...
9
Mice with miR 146a deficiency develop severe gouty arthritis via dysregulation of TRAF 6, IRAK 1 and NALP3 inflammasome
... the NALP3 inflammasome, culminating in the production of ...of NALP3 inflammasome components in macrophages of miR-146a KO mice, as there are no reports indicating that miR-146a directly ...
9
Original Article Resveratrol pretreatment protects rat hearts from ischemia/reperfusion injury partly via a NALP3 inflammasome pathway
... with NALP3 inflam- ...the NALP3 inflammasome signaling pathway still needs to be further ...of NALP3 in MI/RI can be explained in a future study using gene silencing or the application of ...
11
Rhein attenuates inflammation through inhibition of NF-κB and NALP3 inflammasome in vivo and in vitro
... In summary, treatment with rhein significantly decreased the levels of IL-6, IL-1 β , and TNF- α , and reduced the inflammation-associated migration of immune cells. In addition, rhein reduced NO production via ...
9
Acetaminophen induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome
... the inflammasome components Nalp3 (NACHT, LRR, and pyrin domain–containing protein 3), ASC (apoptosis-associated speck- like protein containing a CARD), and caspase-1, we have identified a nonredundant role ...
11
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
... NALP2/ NALP3 inflammasome contains NALP2 or NALP3, the adaptor proteins CARDINAL and ASC, and caspase 1 ...(19). NALP3 is present in the cytoplasm of DCs (20) and associates with ASC, leading ...
6
NOD like receptors and inflammation
... in NALP3 (NLRP3, CIAS1) increase production of these proinflam- matory ...of NALP3 (NLRP3, CIAS1) enhanced monocytic cell death in peripheral blood mononuclear cells of a patient with a mild phenotype of ...
14
Original Article Inhibitory effect of protectin D1 on NALP3 inflammasomes
... on NALP3 inflammsomes in inflammatory res- ponse in sepsis and their mechanisms remain ...lowered NALP3 ASC and Caspase-1 levels in cells, and suppressed the serum of IL-1β and IL-18 concentrations in the ...
7
Gout: will the “King of Diseases” be the first rheumatic disease to be cured?
... of NALP3 inflammasome-induced inflammation in acute gout, the characterization of diagnostic signs on ultrasound and dual-energy computed tomography imaging modalities, the recognition of target serum urate ...
5
Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation
... both NALP3 and IL-1β expression in LPS- stimulated human monocytes in a dose-dependent fash- ...that NALP3 protein expression is decreased by an azithromycin ef- fect at the mRNA level, wherein transcript ...
8
Knockdown of MVK does not lead to changes in NALP3 expression or activation
... lines, NALP3 inflammasome activation is responsible for ini- tiating inflammation ...by NALP3, ASC and Caspase-1, cleaves pro- IL-1β to release its active form, starting inflammation ...Accordingly, ...
5
Toll like receptors and NOD like receptors in rheumatic diseases
... the NALP3 inflammasome [63]. The role of the NALP3 inflammasome was confirmed in a monosodium-urate-induced peritonitis mouse model that mimics an acute gout ...
8
Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii
... 1E). Inflammasome activation is often divided into a signal 1, which is the signal that leads to transcription of Il-1  , and signal 2, which is the signal that leads to the actual activation of ...
12
ADP Ribosylation of NLRP3 by Mycoplasma pneumoniae CARDS Toxin Regulates Inflammasome Activity
... aberrant inflammasome activation can accompany infection-associated disease leading to “hyperinflammation” and exaggerated histopathology and tissue ...NLRP3 inflammasome speck (white ...
11
Original Article Inhibition of ER stress by 4-PBA protects MCT-induced pulmonary arterial hypertension via reducing NLRP3 inflammasome activation
... 4169 Int J Clin Exp Pathol 2017;10(4):4162-4172 shown that NLRP3 was significantly up-regulat- ed in the lung of MCT-treated rats compared with the control group [26]. Wu et al. suggested that the alveolar macrophage ...
11
Original Article Obeticholic acid improves hepatic steatosis and inflammation by inhibiting NLRP3 inflammasome activation
... and inflammation was likely attributed to its inhibiting effect on NLRP3 inflammasome acti- vation which had been proved to be necessary for hepatic inflammation. We also examined whether short-term OCA treatment ...
11
Zebrafish in Inflammasome Research
... study inflammasome function in vivo have started to ...discuss inflammasome research in zebrafish in light of current knowledge about mammalian ...of inflammasome components between zebrafish and ...
14
Contribution of the inflammasome to inflammaging
... chronic inflammation. Inflammaging, or aging-related inflammation, is a risk factor for morbidity and mortality in the elderly population, and it is regulated in part by the innate immune response. Therefore, targeting ...
10
Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins
... Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins Ryan F[.] ...
11