Nasal delivery
The nasal delivery of nanoencapsulated statins – an approach for brain delivery
... for nasal administration, while cytotoxicity of simvastatin-loaded nanoparticles (IC 50 ) was found to be three times lower than the drug solution ...after nasal delivery of simvastatin-loaded ...
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DEVELOPMENT OF FROVATRIPTAN SUCCINATE MICROEMULSION FOR NASAL DELIVERY: OPTIMIZATION, IN VITRO AND IN VIVO EVALUATION
... Microemulsion is a transparent looking product having a droplet size of 20–200 nm composing of oil, surfactant, cosurfactant, and water at suitable proportions. It has several specific physicochemical properties such as ...
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NASAL DELIVERY OF FELODOPINE USING HYDROGEL MATRIX
... the delivery of erythropoietin (Shimoda and Igusa 1987), Insulin (Zirinis 1995), Tamoxifen (Hussain and Dittert 2001), Oxybutynin (Sherrat and Houdi ...for nasal permeation of ...vitro nasal ...
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Preparation of mucoadhesive microspheres for nasal delivery by spray drying
... cromoglycate (DSCG) with either polyacrylic acid (Carbopol 934) or sodium carboxymethylcellulose (NaCMC) by the spray drying technique and evaluated for in vitro characteristics. The current study aimed to observe the ...
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Optimization of systemic nasal delivery of progesterone using polyacrylic acid based gels.
... powder nasal vaccine ...for nasal delivery were characterized for physico-chemical properties and ...on nasal residence time of vaccine powders in rats. Intramuscular delivery provided ...
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Mucoadhesive microspheres of propranolol hydrochloride for nasal delivery
... Rao PR, Reddy MN, Ramakrishna S, Prakash V. Comparative in vivo evaluation of propranolol hydrochloride after oral and transdermal administration in rabbits. Eur J Pharm Biopharm 2003;56:81-5. Ugwoke MI, Verbeke N, ...
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FORMULATION AND EVALUATION OF LEVOCETIRIZINE LOADED MUCOADHESIVE MICROSPHERES FOR NASAL DELIVERY
... for nasal delivery with the aim to enhance the residence time and improve therapeutic efficacy and at the same time increase the Local absorption of drug and reducing systemic side effects and also to ...
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PREPARATION AND CHARACTERIZATION OF CHITOSAN NANOPARTICLES OF INSULIN FOR NASAL DELIVERY
... due to the destruction of gastric pH and gastrointestinal enzymes, as well as its low permeability across the intestinal epithelium 4,5 . Currently new and potent Protein/Peptide drugs are generally administered ...
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Mucoadhesive chitosan microspheres for non-invasive and improved nasal delivery of insulin
... streptozotocine solution in citrate buffer pH 5.0 (65 mg/kg) for 4 to 5 days. The animals that showed fasting blood glucose level more than 300 mg/dl conÞ rmed induction of diabetes were taken for study. These rabbits ...
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Paracellular permeation-enhancing effect of AT1002 C-terminal amidation in nasal delivery
... the nasal administration of mannitol, whereas no significant difference in the mannitol concentration was observed for the formulations of mannitol/ AT1002 or mannitol/Pep2 compared to the control of man- nitol ...
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DEVELOPMENT OF METOCLOPRAMIDE HYDROCHLORIDE IN SITU GEL: NASAL DELIVERY AND PHARMACOKINETICS IN NEW ZEALAND RABBITS
... the nasal mucosa temperature lies between 32 and 35°C ...a nasal mucoadhesive thermoreversible gel with a phase transition temperature in the range 25–34°C, which would remain liquid at room temperature and ...
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Chitosan-Coated Nanoparticles: Effect of Chitosan Molecular Weight on Nasal Transmucosal Delivery
... nose-to-brain delivery has attracted much attention as a mean to deliver drugs more efficiently to the CNS bypassing the ...the nasal cavity is anatomically connected to the CNS via the olfactory system ...
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MODERN ENCROACHMENT AND PROVOCATION IN NASAL DRUG DELIVERY SYSTEM
... ABSTRACT: Nasal drug delivery has occupied an important place in the field of drug delivery ...Transmucosal nasal delivery is a promising drug delivery option where common drug ...
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Novel Delivery Systems for Nasal Adminstration of Anthrax Vaccine
... minutes. Delivery of insulin with this formulation decreased the blood glucose level for between 4-5 h after ...a nasal spray pump. Nasal spray droplets deposited in the nasal cavity will form ...
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NEW APPROCHES OF NASAL DRUD DELIVERY SYSTEM
... the nasal mucosa for drug ...systemic delivery. The anatomy and physiology of the nasal region have been discussed, followed by a discussion of the factors and barriers affecting the drug absorption, ...
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NOVEL DRUG DELIVERY SYSTEM THROUGH NASAL (NON INVASIVE)
... the nasal gel depends on vicious concentration and type of polymer for good results of biopharmaceutics bio-adhesive polymers plays a high role and these results a good improvement of patient complains ...for ...
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Smart polymers in nasal drug delivery
... drug delivery has now been recognized as a promising route for drug delivery due to its capability of transporting a drug to systemic circulation and central nervous ...Though nasal mucosa offers ...
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A review on factors affecting the design of nasal drug delivery system
... Existing nasal delivery devices such as spray pumps and pipettes cannot fully exploit the described potential advantages of nasal ...of nasal administration of drugs and ...most nasal ...
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A REVIEW ON NASAL DRUG DELIVERY SYSTEM AND ITS CONTRIBUTION IN THERAPEUTIC MANAGEMENT
... the nasal cavity and also the use of anesthetics or sedating procedures that can affect the mucociliary clearance mechanism ...the nasal delivery of insulin using the rat model with ...
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In situ gel for nasal drug delivery
... situ nasal gel of insulin using quaternized chitosan HTCC, PEG and ...the nasal cavity of rat from the in situ ...for nasal drug delivery to improve the absorption of hydrophilic ...
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