NCI-60
A map of mobile DNA insertions in the NCI-60 human cancer cell panel
... A total of 749 and 2,100 peaks corresponding to candi- date LINE-1 and Alu insertion sites respectively were recognized across the NCI-60 cell panel. These locations were cross-referenced to previously ...
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Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI 60 screening, mitochondrial targeting, and apoptosis
... (NCI) NCI-60 cell-line screen. Use of the NCI COMPARE algorithm (which predicts mechanisms of action (MoAs) for emerging anticancer compounds by correlating NCI-60 patterns of ...
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Concerted changes in transcriptional regulation of genes involved in DNA methylation, demethylation, and folate-mediated one-carbon metabolism pathways in the NCI-60 cancer cell line panel in response to cancer drug treatment
... When NCI-60 cell lines were treated with 5-azacytidine or vorinostat, the correlation between chemosensitivity, measured as log(GI50), and expression changes of any of the 56 candidate genes involved in DNA ...
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The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel
... the NCI, we ranked the tumor cell lines of the NCI-60 panel by their susceptibility to arsenic trioxide-induced ...the NCI-60 human tumor cell panel with the arsenic trioxide-speci- fic ...
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Concentration of endogenous estrogens and estrogen metabolites in the NCI-60 human tumor cell lines
... using NCI-60 human tumor cell lines, including human breast, central nervous system (CNS), colon, ovarian, prostate, kidney, melanoma, leukemia, and non-small cell lung ...in NCI-60 human ...
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Mirror image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity
... the NCI 60-cell-line screen using the COMPARE algorithm showed that the two potent iodido complexes have surpris- ingly similar selectivity patterns to one another and to an anti-microtubule drug, ...
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Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cells
... While an association between Sox2 and ST6Gal-I mRNA levels has been noted previously [38–40], results herein show that Sox2 and ST6Gal-I expression at the protein level is correlated across multiple ovarian cancer cell ...
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Integrated metabolome and transcriptome analysis of the NCI60 dataset
... with EHMN reaction ID R01758 and R01759, is asso- ciated with L-Arabitol with PQC of 0.69 and PCC of 0.36, which implies strong association between metabo- lite level and gene activity. However, it is surprising that ...
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Extracellular Vesicle Integrins Distinguish Unique Cancers
... Figure 3. Breast cancer EV integrin profiles differ from benign breast cell-derived vesicles. (a) Coommassie-stained gel purification of MCF10a EV proteins. (b) Overlap of total vesicle proteins identified by mass ...
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Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity
... 53 NCI-60 solid tumor cell lines shows a great variation between differ- ent cell lines, with the invaded cell counts (ICC) ranging from 129 to 5,514 (Figure ...
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Newcastle Disease Virus Exerts Oncolysis by both Intrinsic and Extrinsic Caspase-Dependent Pathways of Cell Death
... To assess the oncolytic properties of the rNDV strains, representative cell lines from the NCI-60 human tumor cell panel and other tumor cell lines 14 cell lines from a spectrum of malig[r] ...
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Clickable prodrugs bearing potent and hydrolytically cleavable nicotinamide phosphoribosyltransferase inhibitors
... (DTP) NCI-60 and our molecule 1-(4 ′ -(trans-3 ″ - (3 ‴ -pyridyl)acrylamido)butyl)-1,7-dicarbadodecaborane (MC4-PPEA) was the most potent Nampt inhibitor tested, to date, exhibiting low growth inhibition of ...
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Expression of sulfotransferase SULT1A1 in cancer cells predicts susceptibility to the novel anticancer agent NSC-743380
... the NCI-60 cell line ...in NCI-60 cell lines and characterized the functions of the top associated genes in NSC-743380–mediated anticancer ...
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Identification of potential synthetic lethal genes to p53 using a computational biology approach
... between NCI-60 cell lines with functional p53 mutations and NCI-60 cell lines without functional p53 mutations for the compounds that target the kinases encoded by the genes ...
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PubMedCentral-PMC5154168.pdf
... This study was supported by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology (MEXT KAKENHI, Japan), awarded to K.N.G. (Grant Number 25293024). This work was also supported by NIH ...
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Using titanium complexes to defeat cancer: the view from the shoulders of titans
... Cisplatin (and its derivatives) are archetypal DNA interfering drugs, often used as reference compounds in anticancer research. The limitations of such platinum-based drugs include: efficacy against only a narrow range ...
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NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment
... cell lines (NCI-H345, DMS-53, DMS-146, and NCI-H82). Total RNA was first extracted from cell culture using TRIzol reagent (Invitrogen, Carlsbad, CA, USA) following the manufacturer recommended protocol. The ...
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Effect of Mutations in the Human Immunodeficiency Virus Type 1 Protease on Cleavage of the gp41 Cytoplasmic Tail
... Identification of the cleavage site in the CT of R236L gp41. To identify the site of PR-mediated cleavage in the CT of R236L gp41, we concentrated the virions after transfecting HeLa or 293T cells and purified them by ...
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CD47 blocking immunotherapies stimulate macrophage mediated destruction of small cell lung cancer
... Figure 1. CD47 is a therapeutic target for SCLC. (A) Histological analysis of macrophage infiltration in SCLC patient samples (n = 79). Specimens were stained for the macrophage markers CD68 and CD163. Samples were ...
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Activated Raf 1 causes growth arrest in human small cell lung cancer cells
... cells, NCI- H209 cells and NCI-H510 cells both lack a functional retino- blastoma susceptibility gene (Rb) (19, 20); p53 is mutated in NCI-H510 cells, and is wild-type in NCI-H209 cells ...
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