ncRNAs, miRNAs
Decoding Noncoding RNAs: Role of MicroRNAs and Long Noncoding RNAs in Ocular Neovascularization
... the miRNAs, lncRNAs are longer ncRNAs located in the nucleus and ...the miRNAs [26], nonetheless, they may be 5ʹ ‑ capped, spliced, and 3’-polyadenylated in unconventional ...hosting miRNAs ...
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The emerging world of microRNAs
... were miRNAs (7). miRNAs are approximately 22 nucleotide long, non-coding RNAs (ncRNAs) that bind to partially complementary sequences within the 3’-untranslated region (UTR) of target mRNAs and ...
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Measuring disease similarity and predicting disease-related ncRNAs by a novel method
... Based on our method, researchers can predict novel lncRNA-disease and miRNA-disease associations based on RWR. Firstly, a LSN (MSN) could be constructed for RWR. A lncRNA (miRNA) has associations with a set of diseases. ...
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Dysregulation of ncRNAs located at the DLK1-DIO3 imprinted domain: involvement in urological cancers
... Thus, miRNAs/c-MET/SNAIL negative feedback loop maybe involved in the DLK1-DIO3 imprinted domain of urological cancers; however, above concepts may need more studies to ...the miRNAs in this region of PCa ...
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Noncoding RNAs in cancer therapy resistance and targeted drug development
... of ncRNAs, such as miRNA [1, 2, 5], short hairpin RNA (shRNA) and siRNA [11], lncRNA [4], and circRNA [8–10], is summa- rized in ...that ncRNAs are dysregulated and implicated in various cancer processes, ...
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<p>Long Noncoding RNAs in Diffuse Large B-Cell Lymphoma: Current Advances and Perspectives</p>
... research. ncRNAs, including long noncoding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs, are RNA transcripts of variable length that are not translated into ...as ncRNAs containing more than ...
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Structure of noncoding RNA is a determinant of function of RNA binding proteins in transcriptional regulation
... small ncRNAs, siRNAs and miRNAs, participate in RNAi pathway involved in gene silencing, mRNA stability and transla- tion arrest have been extensively studied ...of ncRNAs are much less well ...of ...
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Noncoding RNAs as novel biomarkers in pancreatic cancer: what do we know?
... of ncRNAs in PDAC we have gained an insight into the pathogenetic mechanisms underlying PDAC, opening the way to improved strategies for the clinical management of PDAC ...of ncRNAs as prognostic and ...
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The function of non coding RNAs in genomic imprinting
... macro ncRNAs can host short ncRNAs The length of the macroRNAs of the imprinted clusters, ...2006), miRNAs, which function as translational gene repressors (reviewed by Cannell et ...two ...
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<p>LncRNA MIR100HG promotes cancer cell proliferation, migration and invasion in laryngeal squamous cell carcinoma through the downregulation of miR-204-5p</p>
... physiological and pathological processes in the form of RNA. 7 Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) with different lengths are two major subgroups of ncRNAs. A growing body of literatures ...
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Hepatitis C virus core impacts expression of miR122 and miR204 involved in carcinogenic progression via regulation of TGFBRAP1 and HOTTIP expression
... of ncRNAs in HCC progression due to HCV chronic infec- tion, we investigated the global and dynamic gene expres- sion profiling of lncRNAs, miRNAs, and circRNAs in the Huh7 cells transfected with HCV ...
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Expression profiles of pivotal microRNAs and targets in thyroid papillary carcinoma: an analysis of The Cancer Genome Atlas
... Upregulated miRNAs (miR-222, miR-221, miR-146b, miR-181a/b/d, miR-34a, and miR-424) and downregulated miRNAs (miR-9-1, miR-138, miR-363, miR-20b, miR-195, and miR-152) were ...several miRNAs ...
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Biogenesis and function of extracellular miRNAs
... Extracellular miRNAs are involved in tumor progression Many tumors can proactively manipulate their sur- rounding microenvironment, thus promoting their survival, growth and ...extracellular miRNAs from ...
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An integrative framework to identify cell death-related microRNAs in esophageal squamous cell carcinoma
... via miRNAs- targets and knowledge database based ...candidate miRNAs may function under certain ...these miRNAs affect autophagy process, we use protein markers, LC3 and P62, to monitor the autophagy ...
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Extracellular vesicle-packaged miRNA release after short-term exposure to particulate matter is associated with increased coagulation
... Although normalization is often advocated as a critical step in miRNA analysis, especially when a fixed volume of sample rather than a fixed quantity of RNA is man- aged, there is no general consensus for the best method ...
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Repertoire of bovine miRNA and miRNA-Like small regulatory RNAs expressed upon viral infection
... We aimed to extend the known repertoire of small regulatory RNAs expressed in bovine tissues and identify miRNA that could be disregulated upon viral infection. We used a cell line derived from the adult bovine kidney ...
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An in silicoanalysis of dynamic changes in microRNA expression profiles in stepwise development of nasopharyngeal carcinoma
... The goal of profiling miRNA expression in this study is to discover the specific miRNAs in which influence the development of NPC. We found that miR-29a/c, miR- 34b, miR-34c-3p, miR-34c-5p, miR-429, miR-203, miR- ...
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Exosomes in Mesenchymal Stem Cells, a New Therapeutic Strategy for Cardiovascular Diseases?
... vivo following internalization by human microvascu- lar endothelial cells (HMECs), while platelet-derived growth factor (PDGF) strengthens this positive influ- ence by means of irritating ASCs to release exosomes and ...
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Changes in cellular microRNA expression induced by porcine circovirus type 2-encoded proteins
... cellular miRNAs mediate the coordinated re- pression of genes in a shared pathway ...several miRNAs whose abundance is affected by PCV2 ORFs may converge to coordinate regulation of compo- nents in the MAPK ...
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Identification of reference miRNAs in plasma useful for the study of oestrogen responsive miRNAs associated with acquired Protein S deficiency in pregnancy
... hormone-responsive miRNAs in human serum and plasma ...oestrogen-responsive miRNAs have pre- dominantly been performed in human breast cancer cell lines [22, 23, 60, 61]; whereas, hormone induced miR- NAs ...
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