neointimal hyperplasia
A mathematical model of venous neointimal hyperplasia formation
... and neointimal hyperplasia after injury to endothelial and smooth muscle cells ...a neointimal expansion that contributes to access stenosis ...of neointimal hyperplasia ...in ...
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Comparisons of the Effects of Stent Eccentricity on the Neointimal Hyperplasia between Sirolimus Eluting Stent versus Paclitaxel Eluting Stent
... Purpose: Previous studies suggested that asymmetric stent expansion did not affect suppression of neointimal hyperplasia (NIH) after sirolimus-eluting stents (SES) implantation. The aim of this study was to ...
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Neointimal hyperplasia persists at six months after sirolimus-eluting stent implantation in diabetic porcine
... Coronary angiography and stent implantation were per- formed after stabilizing blood glucose level in diabetic group (mean 12 ± 4 days after STZ administration). Aspi- rin (Bayer, 300 mg/d) and ticlopidine ...
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Oversizing of Self Expanding Stents: Influence on the Development of Neointimal Hyperplasia of the Carotid Artery in a Canine Model
... neointimal hyperplasia in human beings and in com- monly used animal models, such as those of pigs and dogs, have similarities. The number of cells, their composition, and the accompanying proteoglycan ma- ...
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Pretreatment with intraluminal rapamycin nanoparticle perfusion inhibits neointimal hyperplasia in a rabbit vein graft model
... an indicator to evaluate the antiproliferative efficacy of rapamycin. In preparation of the cell sample, the adventi- tia was removed to exclude interference from fibroblasts in the adventitia. This guarantees that the ...
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Adenovirus-Mediated Gene Transfer of microRNA-21 Sponge Inhibits Neointimal Hyperplasia in Rat Vein Grafts
... target genes PTEN and Bcl-2. In cultured cells, upregulation of miR-21 resulted in increased VSMC proliferation and decreased VSMC apoptosis. By contrast, inhibition of miR-21 decreases the proliferation of VSMCs, and ...
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Neuropilins 1 and 2 mediate neointimal hyperplasia and re-endothelialization following arterial injury
... In contrast, increased re-endothelialization is expected to reduce neointimal hyperplasia, but Ad.NRP1 WT did not have such an effect. We propose that this is because the enhancement of re- ...
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Exosomes derived from mesenchymal stem cells inhibit neointimal hyperplasia by activating the Erk1/2 signalling pathway in rats
... of neointimal hyperplasia, but the effects of endothelial cells have also been considered ...mal hyperplasia remains ...intimal hyperplasia and in a study by Kong et ...and neointimal ...
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Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia
... Citation Newman, K D, P F Dunn, J W Owens, A H Schulick, R Virmani, G Sukhova, P Libby, and D A Dichek. 1995. “Adenovirus-Mediated Gene Transfer into Normal Rabbit Arteries Results in Prolonged Vascular Cell Activation, ...
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Adenovirus mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia
... Adenovirus vectors are capable of high efficiency in vivo arterial gene transfer, and are currently in use as therapeutic agents in animal models of vascular disease. However, despite substantial data on the ability of ...
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Improving arteriovenous fistula patency : transdermal delivery of diclofenac reduces cannulation-dependent neointimal hyperplasia via AMPK activation
... However neointimal hyperplasia and loss of the luminal compartment result in AVF patency rates of ~60% at 12 ...of neointimal hyperplasia in the AVF is poorly ...cant neointimal ...
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Promoting endothelial recovery and reducing neointimal hyperplasia using sequential-like release of acetylsalicylic acid and paclitaxel-loaded biodegradable stents
... culture indicated that the eluted drug promoted endothelial cell proliferation on days 3 and 7, and reduced SMC prolifera- tion in weeks 2, 4, and 8, relative to the control groups. More- over, the stent significantly ...
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Effects of Combination Therapy with Celecoxib and Doxycycline on Neointimal Hyperplasia and Inflammatory Biomarkers in Coronary Artery Disease Patients Treated with Bare Metal Stents
... Purpose: Cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 play a key role in the pathogenesis of in-stent restenosis. We investigated the effect of a short-term therapy of celecoxib, a COX-2 inhibitor, with or ...
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Luseogliflozin attenuates neointimal hyperplasia after wire injury in high-fat diet-fed mice via inhibition of perivascular adipose tissue remodeling
... the neointimal hyperplasia after arterial injury in this animal model [10, ...to neointimal hyperplasia after wire injury in ...wire-injured neointimal hyperplasia in ...
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Patient specific, multi scale modeling of neointimal hyperplasia in vein grafts
... Neointimal hyperplasia is amongst the major causes of failure of bypass ...understand neointimal hyperplasia in individual patients, combining information from biological experiments and ...
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The effects of PPARγ agonist rosiglitazone on neointimal hyperplasia in rabbit carotid anastomosis model
... diminished neointimal hyperplasia and inflammatory events by reducing numbers and interac- tions of inflammatory cells and also negatively regulating the activations of inflammatory markers such as p38 ...
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Rapamycin-loaded nanoparticles for inhibition of neointimal hyperplasia in experimental vein grafts
... [2]. Neointimal hyperplasia, which develops immediately after grafting, is the most important early change of the grafted ...this neointimal process is to be regarded as the guiding track easing the ...
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Smooth muscle cell–specific fibronectin EDA mediates phenotypic switching and neointimal hyperplasia
... modulate neointimal hyperplasia in injured human vessels by promoting SMC pheno- typic modulation, proliferation, and migration via upregulation of the Akt1/mTOR signaling pathway (Figure ...
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Age-related changes in monocytes exacerbate neointimal hyperplasia after vascular injury
... In contrast to the high number of adhesion molecules, chemotactic factors and inflammatory mediators overexpressed in monocytes from aged rats, up-regulated genes in cells isolated from [r] ...
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Perivascular mast cells regulate vein graft neointimal formation and remodeling
... Results. Neointimal hyperplasia was induced by insertion of a vein graft into the right carotid artery in wild type and mast cell deficient Kit W - sh/W - sh ...graft neointimal lesion formation was ...
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