Netrin-1
Ultrasound molecular imaging as a non-invasive companion diagnostic for netrin-1 interference therapy in breast cancer
... For netrin-1 immunostaining, a previously described IgG localization technique, here called IVIL, was applied, as standard ex vivo immunofluorescence staining was prevented by the specificity of NET1-H-mAb ...
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Egr-1 increases angiogenesis in cartilage via binding Netrin-1 receptor DCC promoter
... Lewis rats (260–280 g) were purchased from Chengdu Da Shuo Biotech Co. Ltd. (Chengdu, China) and ran- domized to the sham group and OA group, n = 8 per group. The rat OA model was performed as anterior cruciate ligament ...
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Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability
... The netrin-1 receptor, DCC, was discovered as a puta- tive tumor suppressor gene in colorectal cancer ...for netrin-1 have renewed the hypothesis that DCC functions as a pro- apoptotic growth ...
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Subrepellent doses of Slit1 promote Netrin-1 chemotactic responses in subsets of axons
... of Netrin-1/ Slit1 trigger this combinatorial activity on rostral thal- amic axons and whether it is specific to this axonal population remain to be ...
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Determination of Netrin-1 Levels in Patients that Applied to Emergency Department with Stroke and Its Effects on Survival for 6 Months
... of netrin, although there is no statistically significan correlation between NIHSS level of netrin at the admission of case group (p=0,705), which can be monitored in patients with increased levels of NIHSS ...
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Expression of netrin-1 receptors in retina of oxygen-induced retinopathy in mice
... of netrin-1 in OIR mice on P17, so there was also a positive correlation between netrin-1 overexpression and UNC5B overexpression in OIR mice on P17, suggesting that UNC5B mediated ...
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Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer
... that netrin-1 was expressed in the acini of normal pancreatic tissue and that this expression was significantly reduced in early- stage PDAC ...samples. Netrin-1 over-expression notably ...
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Distinct functions for netrin 1 in chicken and murine semicircular canal morphogenesis
... The vestibular system of the inner ear detects head position using three orthogonally oriented semicircular canals; even slight changes in their shape and orientation can cause debilitating behavioral defects. During ...
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Hypoxia inducible factor 1 controls the expression of the uncoordinated 5 B receptor, but not of Netrin 1, in first trimester human placenta
... homologs 1-4 (UNC5H1-4) transmembrane netrin receptors are re- ported to control a number of cellular processes, including axonal guidance, angiogenesis and cell ...ligand, netrin. We have recently ...
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Truncated netrin 1 contributes to pathological vascular permeability in diabetic retinopathy
... Truncated netrin-1 isoforms are present in the vitreous humor of patients with ...of netrin-1 in DR, we first investigated protein levels in vitreous humor from patients with DME, selected ...
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The level of netrin-1 is decreased in newly diagnosed type 2 diabetes mellitus patients
... First, netrin-1 has a role in inflammation, which is impli- cated in the pathogenic mechanism of ...that netrin-1 could regulate inflammation, which might negatively regulate insulin secretion ...
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Netrin 1 regulates ventral tangential migration of guidepost neurons in the lateral olfactory tract
... expressing netrin 1 (A,B) and the mock control cells ...anti-reticulon 1 antibody (green in ...the netrin 1-secreting cells, but not the control ...expressing netrin 1 ...
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Cross repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear
... Fig. 1. Patterning and morphogenesis of the inner ear. Diagrams of the transformation of the otic vesicle into the mature structure of the inner ear. Early in development (left), the axes of the otic vesicle are ...
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MUC4-promoted neural invasion is mediated by the axon guidance factor netrin-1 in PDAC
... NI is a special pattern of invasion and a characteristic pathological feature of PDAC, which correlates with the progression and prognosis in PDAC [23]. Different from conventional invasion, NI of PDAC includes two ...
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Dorsally derived netrin 1 provides an inhibitory cue and elaborates the `waiting period' for primary sensory axons in the developing spinal cord
... days. Netrin 1 is a long-range diffusible factor expressed in the ventral midline of the developing neural tube, and has chemoattractive and chemorepulsive effects on growing ...axons. Netrin ...
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Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1
... 2002), netrin 1 also inhibits ...to netrin 1-mediated ...to netrin 1. (A) SCN adherence to netrin 1 is increased by 79% (n = 12, ...either: netrin function ...
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Netrin 1 controls sympathetic arterial innervation
... of netrin-1 expression and absence of one copy of the Ntn1 gene, was sufficient to severely impair arterial innervation in small- diameter resistance arteries branching off the iliac and femoral artery as ...
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Netrin-1 directs dendritic growth and connectivity of vertebrate central neurons in vivo
... of netrin on tectal neurons since neurons responded to acute changes in netrin-1 levels and to altered DCC signaling by effect- ively remodeling and reorienting their ...DCC-mediated netrin ...
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Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA
... of netrin 1, an increased amount of Fyn co-immunoprecipitated with Dcc ...of netrin 1 to oligodendrocytes recruits Fyn into a complex with FAK that is bound to the intracellular domain of Dcc, ...
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Netrin-1 overexpression is predictive of ovarian malignancies
... Netrin-1 (NTN1) is functionally important for the development of the nervous system. Interestingly, few recent studies showed that NTN1 may also promote cancer by increasing survival and resistance of lung ...
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