Neural Stem Cell (NSC)
Neural stem cell sex dimorphism in aromatase (CYP19) expression: a basis for differential neural fate
... Purpose: Neural stem cell (NSC) transplantation and pharmacologic activation of endogenous neurogenesis are two approaches that trigger a great deal of interest as brain repair ...using stem ...
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Investigation of Sox9 Ablation on Neural Stem Cell Behaviour after Spinal Cord Injury
... activates neural stem cells and causes them to proliferate rapidly (Johansson, Momma et ...that neural stem cells and their progeny migrate to the lesion site and contribute to the glial scar ...
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Original Article Neural stem cell transplantation promotes behavioral recovery in a photothrombosis stroke model
... neural stem cells on lesion volume and behav- ioral outcomes after ischemic ...of neural stem cells degraded infarct volume and neuro- logical ...that neural stem cells derived ...
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Neural stem cell-derived exosomes mediate viral entry
... Results: Exosomes significantly enhanced Ad5 entry in Coxsackie virus and adenovirus receptor (CAR)-deficient cells, in which Ad5 only had very limited entry. The exosomes were shown to contain T-cell ...
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Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury
... Our data are consistent with a previous report demonstrating that SCF expression is induced by brain injury in neurons sur- rounding the injury, as assessed by in situ hybridization and immunohistochemistry (61). ...
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Neural stem cell like cells derived from autologous bone mesenchymal stem cells for the treatment of patients with cerebral palsy
... The main limitations of this study include the small sam- ple size and the lack of a randomised, double-blinded, placebo-controlled design. However, we employed an ob- server-blinded, controlled design to minimize ...
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Neural stem cell therapy for subacute and chronic ischemic stroke
... Our ability to address neurovascular diseases will require multifaceted solutions, including pharmacological, cell re- placement, genetic, and tissue engineering. The funda- mental biological attributes of NSCs ...
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Fluorescent polymeric nanovehicles for neural stem cell modulation
... For multipotency assessment, NSCs were allowed to differen- tiate for 5 days in vitro on matrigel coated glass cover slips. Cells were seeded in 24-well plates at a density of 80 000 cells per well in 500 μl cell ...
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Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors
... of neural progenitors from PSCs, our ability to address the dynamic changes in self-renewal and potency of distinct NSC types in vitro has remained ...neuronal cell type generation 4 ...RG cell types ...
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Biophysical characteristics reveal neural stem cell differentiation potential
... the stem cell populations, NSPCs were induced to differentiate and the generation of neurons and astrocytes ...each cell population and used nuclei stained by Hoechst 33342 (2 m g/ml in phosphate- ...
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Bioluminescence imaging of stroke induced endogenous neural stem cell response
... In 6 out of 8 Nestin-CreERT2/Fluc mice receiving stroke, a distinctive in vivo BLI signal originating from the stroke region could be detected, which could not be detected in sham or in [r] ...
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The Specificity Protein 2 (Sp2) in the Proliferation and Cell Cycle Progression of the Neural Progenitors.
... parent neural stem cell are amplified through IPCs and this process is proposed to largely determine the size of distinct neuronal populations, which ultimately impact cortical size and ...
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The promise of stem cells in the therapy of Alzheimer’s disease
... of stem cells as donor cells and investigated the effects of stem cell transplantation on relieving neuropathological symptoms and restoring cognitive function of transgenic AD animal ...Adult ...
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Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations
... iPS cell lines: 201B7 iPSCs purchased from RIKEN BRC and were kindly pro- vided by ...for cell differentiation and analysis were approved by the re- spective Ethics Committees of Keio University School of ...
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Comparing adult renal stem cell identification, characterization and applications
... that stem cells found in the papilla are involved in normal maintenance of the nearby tubules and collecting ducts, these cells also ap- pear to respond to renal ischemic injury ...Individual cell migration ...
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Drosophila neuroblasts: a model for stem cell biology
... asymmetric cell divisions along the apical-basal axis of the overlying epithelium (Yoshiura et ...the cell (Rebollo et ...the cell fate determinants Brain tumor (Brat), Prospero (Pros) and Numb to ...
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p57kip2 regulates glial fate decision in adult neural stem cells
... suppressed SGZ cells displayed raised transcript levels of the polycomb group protein EZH2 (Fig. 5A), which was shown to be expressed at high levels in NSCs that differentiate into OPCs (Sher et al., 2008). In addition, ...
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Advances in stem cell therapy for spinal cord injury
... of stem cell therapy for SCI still faces enor- mous challenges, although much has been learned from previ- ous SCI and other ...for cell transplanta- tion trials, the target SCI population has been ...
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Sox1 marks an activated neural stem/progenitor cell in the hippocampus
... Following the 12-week chase, most neuroblasts were not marked by lineage tracing and hence were not arising from the Sox1- labeled radial astrocytes (Fig. 5C). This finding may reflect a cyclic expression of Sox1. That ...
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Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation
... by cell membrane stretch ...in cell division and might perpetuate Panx1 mediated ATP release and downstream purinergic receptor signaling, resulting in continued ...including cell proliferation and ...
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