neuraminidase inhibitor
Evaluation of Neuraminidase Enzyme Assays Using Different Substrates To Measure Susceptibility of Influenza Virus Clinical Isolates to Neuraminidase Inhibitors: Report of the Neuraminidase Inhibitor Susceptibility Network
... J. L. McKimm-Breschkin, M. Zambon, and F. G. Hayden are mem- bers of the Neuraminidase Inhibitor Susceptibility Network. Other members include M. Aymard, Universite´ Claude Bernard, Lyon, France; A. ...
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Impact of outpatient neuraminidase inhibitor treatment in patients infected with influenza A(H1N1)pdm09 at high risk of hospitalization: an Individual Participant Data (IPD) meta analysis
... Impact of Outpatient Neuraminidase Inhibitor Treatment in Patients Infected With Influenza AH1N1pdm09 at High Risk of Hospitalization: An Individual Participant Data Metaanalysis Sudhir [r] ...
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Unique Determinants of Neuraminidase Inhibitor Resistance among N3, N7, and N9 Avian Influenza Viruses
... Neuraminidase inhibitor resistance screening in avian N7 NAs. The first report of human infection with low-pathogenicity avian influenza H7N7 virus was published in the United Kingdom in 1996 (52). However, ...
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Importance of Neuraminidase Active-Site Residues to the Neuraminidase Inhibitor Resistance of Influenza Viruses
... Neuraminidase inhibitors (NAIs) are antivirals designed to target conserved residues at the neuraminidase (NA) enzyme active site in influenza A and B viruses. The conserved residues that interact with NAIs ...
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Characterization of mutants of influenza A virus selected with the neuraminidase inhibitor 4-guanidino-Neu5Ac2en.
... Since the NA is an essential gene product for virus propa- gation and possesses an enzyme active site whose amino acid sequence is conserved among types and subtypes of influenza viruses, it has been considered a ...
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Influenza Virus Inactivation for Studies of Antigenicity and Phenotypic Neuraminidase Inhibitor Resistance Profiling
... and neuraminidase (NA) characteristics, and  -propiolactone inactivation reduced the hemagglutination titer and NA activity of the human influenza virus 10-fold or ...NA inhibitor susceptibility assays, ...
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Evidence of Synergistic Activity of Medicinal Plant Extracts against Neuraminidase Inhibitor Resistant Strains of Influenza Viruses
... The frequent emergence of drug resistant influenza viral strains emphasizes the urgent and con- tinual need to develop new antiviral drugs. Given the encouraging findings of previous studies on antiviral compounds from ...
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In Vitro Selection and Characterization of Influenza A (A/N9) Virus Variants Resistant to a Novel Neuraminidase Inhibitor, A-315675
... of neuraminidase (NA) inhibitors into clinical practice for the treatment of influenza virus infections, considerable attention has been focused on the potential for resistance development and cross-resistance ...
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Neuraminidase Inhibitor-Resistant Recombinant A/Vietnam/1203/04 (H5N1) Influenza Viruses Retain Their Replication Efficiency and Pathogenicity In Vitro and In Vivo
... Effective antiviral drugs are essential for early control of an influenza pandemic. It is therefore crucial to evaluate the possible threat posed by neuraminidase (NA) inhibitor-resistant influenza viruses ...
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Competitive Fitness of Influenza B Viruses with Neuraminidase Inhibitor-Resistant Substitutions in a Coinfection Model of the Human Airway Epithelium
... The addition of oseltamivir during coinfection of NHBE cells resulted in the superior fitness of influenza B viruses containing the E119A, H274Y, or N294S NA substitution compared to tha[r] ...
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Enhanced Expression of an α2,6 Linked Sialic Acid on MDCK Cells Improves Isolation of Human Influenza Viruses and Evaluation of Their Sensitivity to a Neuraminidase Inhibitor
... of neuraminidase (NA) inhibitors to treat influenza virus infections mandates close monitoring for resistant ...NA inhibitor (oseltamivir) in an MDCK cell line expressing the ST6Gal I ...NA ...
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Screening for Neuraminidase Inhibitor Resistance Markers among Avian Influenza Viruses of the N4, N5, N6, and N8 Neuraminidase Subtypes
... Although neuraminidase (NA) inhibitors (NAIs) are the only class of antiviral drugs available for therapeutic intervention for AIV-infected patients, studies on NAI resistance among AIVs have been limited, and ...
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Antivirals for influenza: where now for clinical practice and pandemic preparedness?
... neuraminidase inhibitors (F. Hoffmann-La Roche: oseltamivir (Tamiflu®) and GSK: zanamivir (Relenza®)) and received grant support for RCTs of both drugs (cited in the Cochrane review) more than 10 years ago. He was ...
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Impact of antiviral treatment and hospital admission delay on risk of death associated with 2009 A/H1N1 pandemic influenza in Mexico
... Several strengths and caveats of our study are worth noting. We used data on ILI and laboratory-confirmed influenza cases reported to the IMSS, where about one- third of all ILI cases were consistently tested for influ- ...
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Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta analysis of individual participant data
... (yes or no), early versus late neuraminidase inhibitor, early versus no neuraminidase inhibitor, and later (>2 days) versus no neuraminidase inhibitor. Covariates were then ...
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A Broadly Neutralizing Human Monoclonal Antibody Directed against a Novel Conserved Epitope on the Influenza Virus H3 Hemagglutinin Globular Head
... Recently, a few globular head-targeting MAbs have been discovered that exhibit activity against different subtypes of influenza subtypes, such as H1; however, none of the previously described MAbs showed broadly ...
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Disruption of Myxoviruses with Tween 20 and Isolation of Biologically Active Hemagglutinin and Neuraminidase Subunits
... Neuraminidase 0.499 0.341 0.276 Laver and Valentine 17 reported that copolymers of hemagglutinin and neuraminidase a Tween 20-treated virus was centrifuged at 60,000 X g for 30 min, and [r] ...
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A Novel Neuraminidase Dependent Hemagglutinin Cleavage Mechanism Enables the Systemic Spread of an H7N6 Avian Influenza Virus
... ABSTRACT In this study, we demonstrate a novel mechanism for hemagglutinin (HA) activation in a naturally occurring H7N6 avian influenza A virus strain, A/mallard duck/Korea/6L/2007 (A/Mdk/6L/07). This novel mechanism ...
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Intracellular Synthesis of Myxovirus Neuraminidase in Chick Embryo Cell Monolayer Culture I. Neuraminidase Activity, Hemagglutinin Synthesis, and Content of Cell-bound Sialic Acid in Newcastle Disease Virus-infected Cells
... Neuraminidase Activity, Hemagglutinin Synthesis, and Content of Cellbound Sialic Acid in Newcastle Disease Virus-infected Cells' Received for publication 5 December 1966 Neuraminidase Na[r] ...
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Novel antiviral activity of neuraminidase inhibitors against an avian influenza a virus
... NA inhibitor is known to affect viral infection efficiency at the initial stage of infection ...NA inhibitor, in order to adjust the concentration immediately before the infectivity ...NA inhibitor ...
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