Neuregulin 1
Association between Neuregulin-1 Gene Variant (rs2439272) and Schizophrenia and its Negative Symptoms in an Iranian Population
... Neuregulin-1 gene is involved in different neurodevelopmental processes (15). It was shown that mutations in NRG1 or ErbB (NRG1 receptor) genes induce a reduction in the number of interneurons in the ...
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Neuregulin 1 signaling is essential for nerve dependent axolotl limb regeneration
... The Mexican axolotl (Ambystoma mexicanum) is capable of fully regenerating amputated limbs, but denervation of the limb inhibits the formation of the post-injury proliferative mass called the blastema. The molecular ...
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Overexpression of Neuregulin 1 Type III Confers Hippocampal mRNA Alterations and Schizophrenia Like Behaviors in Mice
... Neuregulin 1 (NRG1) is a schizophrenia candidate gene whose protein product is involved in neuronal migration, survival, and synaptic plasticity via production of spe- cific ...
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Original Article The effect of neuregulin-1 on the survival of Schwann-like cells via the PI3K/Akt/Bad pathway
... of neuregulin-1 (NRG) on the differentiation of Schwann cells (SCs) and evaluated the role of NRG in the phosphoinositide-3-kinase (PI3K)/ protein kinase B (Akt)/Bad ...
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Original Article Neuregulin 1 is required for the development of enteric neurons and vagus in zebrafish
... Recently genome-wide association studies (GWAS) have identified that neuregulin 1 (nrg1) may be a susceptibility locus for HSCR [15-17]. Nrg1 and its receptors, the ErbB family of tyro- sine kinase ...
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Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy
... [6]. Neuregulin 1 (NRG1) is a growth fac- tor that interacts with Erb B receptors, which localize pri- marily to Schwann cells (SC), and is critical for both SC differentiation and ...
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Rabe, Linnea (2013): Regulierte intramembranäre Proteolyse von Typ I Neuregulin 1-β. Dissertation, LMU München: Medizinische Fakultät
... pathways. Neuregulin 1 (NRG1) type III is involved in myelination of the peripheral nervous system, for which it requires proteolytic activation by proteases of the ADAM family and ...
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Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons
... Neuregulin 1 (NRG1), is an epidermal growth factor (EGF)-like trophic factor implicated in neural develop- ment, synaptic transmission and plasticity, Schwann cell differentiation, and the regulation of ...
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SNP8NRG433E1006 NEUREGULIN-1 GENETIC VARIATION IN BATAKS ETHNIC WITH SCHIZOPHRENIA PARANOID AND HEALTHY CONTROL
... The neuregulin 1 (NRG1) gene which influences the development of white matter connectivity has been associated with ...SNP8NRG433E1006 neuregulin 1 between Bataks ethnic with schizophrenia ...
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Neuronal Neuregulin 1 type III directs Schwann cell migration
... Neuregulin 1 (Nrg1) signals through ErbB receptors and functions throughout Schwann cell development, influencing cell fate specification, motility, proliferation, survival and myelination (Garratt et ...
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Dysregulation of Neuregulin-1/ErbB signaling in the hippocampus of rats after administration of doxorubicin
... that Neuregulin-1 (NRG1) and its ErbB receptors play an essential role in neural function, much is still unknown concerning the biological link between the NRG1/ErbB pathway and the Dox-induced ...
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Neuregulin-1 attenuates mortality associated with experimental cerebral malaria
... survival. Neuregulin-1 (NRG-1) is a neurotrophic growth factor shown to protect against brain injury associated with acute ischemic stroke (AIS) and neurotoxin ...
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RESEARCH ARTICLE Association between a single nucleotide polymorphism in neuregulin-1 and schizophrenia in Pakistani patients
... human neuregulin-1-glial growth factor 2 gene sequence, which served as a reference ...the neuregulin-1 gene by aligning test and control sequences with the neuregulin-1-glial ...
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<p>Cornel Iridoid Glycoside Protects Against White Matter Lesions Induced by Cerebral Ischemia in Rats via Activation of the Brain-Derived Neurotrophic Factor/Neuregulin-1 Pathway</p>
... Methods: Adult male Sprague-Dawley rats underwent middle cerebral artery occlusion (MCAO) surgery for 2 h, followed by reperfusion. Rats were intragastrically administered CIG (60 mg/kg and 120 mg/kg) beginning 6 h ...
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Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin 1/ErbB signaling
... members, neuregulin-1β (NRG-1β, a paracrine factor produced from endothelium) induced remarkable tyrosine phosphorylation of Gab1 and Gab2 via erythroblastic leukemia viral oncogene (ErbB) ...angiopoietin ...
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Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury
... for 1 h at 4°C. Sections were then incubated for 1 h at 37°C with mouse monoclonal anti-ED1 (1:500, MAB1435, Millipore) and anti-CD11b (1:500, CBL1512, Millipore) ...for 1 h at room ...
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Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling
... mammary glands, and the nervous system [10]. In agree- ment with the known capacity of NRG-1 to attenuate neuronal apoptosis [17], we demonstrate that NRG-1 protects heme-induced endothelial and neuroglial ...
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Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway
... Microarray analysis was performed as we previously described [3, 48, 49]. Animals were sacrificed, and their brains removed 24 h following MCAO. Removed brains were sliced into 2-mm coronal sections (ap- proximately +3.0 ...
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Pharmacological postconditioning with Neuregulin-1 mimics the cardioprotective effects of ischaemic postconditioning via ErbB4-dependent activation of reperfusion injury salvage kinase pathway
... In the Langendorff experiments, AG1478 could effectively block the activation of NRG-1/ErbB4 pathway after IP treat- ment, and diminish the activation of the RISK pathway (Fig. 5). These findings suggested that ...
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Changes of neuregulin-1(NRG-1) expression in a rat model of overactive bladder induced by partial urethral obstruction: is NRG-1 a new biomarker of overactive bladder?
... In humans, NRG-1 protein is encoded by the NRG-1 gene [7,35] and is a member of the epidermal growth factor (EGF) family known to activate proliferation, dif- ferentiation, and survival of many tissue types ...
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