Neuregulin-1 (NRG1)
Association between Neuregulin-1 Gene Variant (rs2439272) and Schizophrenia and its Negative Symptoms in an Iranian Population
... Objective: Although the etiology of schizophrenia is unknown, it has a significant genetic component. A number of studies have indicated that neuregulin-1 (NRG1) gene may play a role in the pathogenesis ...
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Original Article Neuregulin 1 is required for the development of enteric neurons and vagus in zebrafish
... Abstract: Hirschsprung’s disease (HSCR) is a congenital malformation of the colon characterised by the absence of enteric ganglion in the submucosal and myenteric plexuses. Recently genome-wide association studies have ...
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Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons
... Neuregulin 1 (NRG1), is an epidermal growth factor (EGF)-like trophic factor implicated in neural develop- ment, synaptic transmission and plasticity, Schwann cell differentiation, and the regulation of ...
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Neuronal Neuregulin 1 type III directs Schwann cell migration
... Neuregulin 1 (Nrg1) signals through ErbB receptors and functions throughout Schwann cell development, influencing cell fate specification, motility, proliferation, survival and myelination (Garratt et ...
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Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy
... [6]. Neuregulin 1 (NRG1) is a growth fac- tor that interacts with Erb B receptors, which localize pri- marily to Schwann cells (SC), and is critical for both SC differentiation and ...
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Rabe, Linnea (2013): Regulierte intramembranäre Proteolyse von Typ I Neuregulin 1-β. Dissertation, LMU München: Medizinische Fakultät
... pathways. Neuregulin 1 (NRG1) type III is involved in myelination of the peripheral nervous system, for which it requires proteolytic activation by proteases of the ADAM family and ...
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Overexpression of Neuregulin 1 Type III Confers Hippocampal mRNA Alterations and Schizophrenia Like Behaviors in Mice
... Neuregulin 1 (NRG1) is a schizophrenia candidate gene whose protein product is involved in neuronal migration, survival, and synaptic plasticity via production of spe- cific ...
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Neuregulin 1 signaling is essential for nerve dependent axolotl limb regeneration
... protein, Neuregulin-1, is capable of supporting blastemal growth and tissue regeneration up to the point of digit formation in the denervated axolotl ...
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Original Article The effect of neuregulin-1 on the survival of Schwann-like cells via the PI3K/Akt/Bad pathway
... of neuregulin-1 (NRG) on the differentiation of Schwann cells (SCs) and evaluated the role of NRG in the phosphoinositide-3-kinase (PI3K)/ protein kinase B (Akt)/Bad ...
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SNP8NRG433E1006 NEUREGULIN-1 GENETIC VARIATION IN BATAKS ETHNIC WITH SCHIZOPHRENIA PARANOID AND HEALTHY CONTROL
... The neuregulin 1 (NRG1) gene which influences the development of white matter connectivity has been associated with ...SNP8NRG433E1006 neuregulin 1 between Bataks ethnic with schizophrenia ...
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Dysregulation of Neuregulin-1/ErbB signaling in the hippocampus of rats after administration of doxorubicin
... that Neuregulin-1 (NRG1) and its ErbB receptors play an essential role in neural function, much is still unknown concerning the biological link between the NRG1/ErbB pathway and the Dox-induced ...
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<p>Cornel Iridoid Glycoside Protects Against White Matter Lesions Induced by Cerebral Ischemia in Rats via Activation of the Brain-Derived Neurotrophic Factor/Neuregulin-1 Pathway</p>
... Methods: Adult male Sprague-Dawley rats underwent middle cerebral artery occlusion (MCAO) surgery for 2 h, followed by reperfusion. Rats were intragastrically administered CIG (60 mg/kg and 120 mg/kg) beginning 6 h ...
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Neuregulin-1 attenuates mortality associated with experimental cerebral malaria
... survival. Neuregulin-1 (NRG-1) is a neurotrophic growth factor shown to protect against brain injury associated with acute ischemic stroke (AIS) and neurotoxin ...
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RESEARCH ARTICLE Association between a single nucleotide polymorphism in neuregulin-1 and schizophrenia in Pakistani patients
... human neuregulin-1-glial growth factor 2 gene sequence, which served as a reference ...the neuregulin-1 gene by aligning test and control sequences with the neuregulin-1-glial ...
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Increased expression of neuregulin 1 in the urothelium of rat bladder with partial bladder outlet obstruction
... Neuregulin (NRG) 1 is a trophic factor in the family of growth factors, and it contains an epidermal growth factor (EGF)-like domain. The roles of NRG1 in synaptic plasticity, neuronal and glial development ...
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Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway
... Microarray analysis was performed as we previously described [3, 48, 49]. Animals were sacrificed, and their brains removed 24 h following MCAO. Removed brains were sliced into 2-mm coronal sections (ap- proximately +3.0 ...
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Cognitive outcome and gamma noise power unrelated to neuregulin 1 and 3 variation in schizophrenia
... The analysis of NRG1 rs6994992, NRG1 rs3924999 and NRG3 rs10748842 promoter polymorphisms was carried out using allelic discrimination with real-time polymerase chain reaction (PCR). The final volume of the reaction con- ...
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Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling
... The neuregulin family of ligands consist of four mem- bers, neuregulin 1β (NRG-1), NRG-2, NRG-3, and NRG- ...the neuregulin/NRG-1 gene located on the short arm of chromosome 8 [17, ...
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Type III neuregulin 1 regulates pathfinding of sensory axons in the developing spinal cord and periphery
... were immunolabeled for surface Nrp1. (C) Quantification of surface Nrp1 in WT and mutant growth cones. Results are measures of the average fluorescence intensity (AFI) per unit area to normalize for differences in ...
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Pharmacological postconditioning with Neuregulin-1 mimics the cardioprotective effects of ischaemic postconditioning via ErbB4-dependent activation of reperfusion injury salvage kinase pathway
... (Gu et al., 2010). A phase II clinical trial demonstrated that NRG-1 significantly enhanced cardiac function in pa- tients with chronic heart failure (Gao, 2010). NRG-1 also suppressed apoptosis in injured ...
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