neurite outgrowth
FANCC localizes with UNC5A at neurite outgrowth and promotes neuritogenesis
... damage and oxidative stress. Fanconi anemia (FA) is a genetic disease associated with defective hematopoiesis, cancer proneness and developmental deficiencies [8, 9]. Although the primary role of FA proteins is ...
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Schwann cell-like differentiated adipose stem cells promote neurite outgrowth via secreted exosomes and RNA transfer
... in neurite outgrowth. To test if the effects of exosomes on neurite outgrowth could be mediated by RNA trans- fer, in some experiments we also first exposed exosomes to UV-light for 2 × 30 ...
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Neurite outgrowth stimulatory effects of culinary medicinal mushrooms and their toxicity assessment using differentiating Neuro 2a and embryonic fibroblast BALB/3T3
... for neurite outgrowth activity are triterpenoids, such as lucidenic acid [26], 7-oxo-ganoderic acid Z, ganolucidic acid A, methyl ganoderic acid A, ganoderic acid S1, and ...
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A Genetic Screen for Neurite Outgrowth Mutants in Caenorhabditis elegans Reveals a New Function for the F-box Ubiquitin Ligase Component LIN-23
... (ectopic/erratic neurite outgrowth) mutants, that display defects in axon outgrowth of specific neuron ...axon outgrowth in a subset of several distinct neuron classes, including ventral nerve ...
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Myocardin related transcription factors regulate the Cdk5/Pctaire1 kinase cascade to control neurite outgrowth, neuronal migration and brain development
... in neurite outgrowth and migration in MRTF bdKO mice, we performed microarray analysis on cortical samples from control and MRTF bdKO brains at P0 (GEO accession number ...
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Original Article miR-26b inhibits total neurite outgrowth, promotes cells apoptosis and downregulates neprilysin in Alzheimer’s disease
... After 24 h plasmids transfection, the expres- sion of miR-26b in each group was detected by qRT-PCR. Then, cells morphology was observed and total neurite outgrowth was quantified by inversion fluorescence ...
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Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin
... Abstract. Cdc42Hs is involved in cytoskeletal reorgani- zation and is required for neurite outgrowth in N1E-115 cells. To investigate the molecular mechanism by which Cdc42Hs regulates these processes, a ...
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The effect of glial fibrillary acidic protein expression on neurite outgrowth from retinal explants in a permissive environment
... Increased expression of GFAP is an important marker of glial activation after injury to the CNS [35]; however, what this increase means for the survival of surrounding neurons and the potential for axon regeneration from ...
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Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1
... of neurite outgrowth in culture have not directly tested whether APPs-α appli- cation can rescue the effects of APP ...increased neurite outgrowth ...inhibit neurite out- ...promotes ...
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HIV-1 Tat-shortened neurite outgrowth through regulation of microRNA-132 and its target gene expression
... ling neurite outgrowth: MecP2, which is a potentiating factor of neurite growth, and p250GAP, which inhibits the outgrowth of neurites [27, ...to neurite growth while this microRNA ...
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Enhancing Effect of Aged Garlic Extract on Induction of Morphological Differentiation with Neurite Outgrowth in NGF treated PC12 Cells
... with neurite outgrowth in nerve growth factor (NGF)-treated PC12 ...with neurite outgrowth in PC12 ...with neurite outgrowth in NGF-treated PC12 cell and SAMC was one of its ...
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DNA topoisomerase IIβ stimulates neurite outgrowth in neural differentiated human mesenchymal stem cells through regulation of Rho-GTPases (RhoA/Rock2 pathway) and Nurr1 expression
... section. Neurite outgrowth in topo IIβ- deficient cells decreased from 200 ± 15% to 155 ± 12% at day 1, and 195 ± 9% to 120 ± 18% at day 5 compared with untransfected cells (p < ...the neurite ...
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Original Article The protection of acetylcholinesterase inhibitor on β-amyloid-induced injury of neurite outgrowth via regulating axon guidance related genes expression in neuronal cells
... induced neurite outgrowth, the NGF receptor TrkA activates several small G pro- teins, including Ras, Rap1, and the Cdc42- Rac1-RhoA family ...of neurite-bearing cells with a significant ...
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Neurite outgrowth stimulatory effects of myco­synthesized AuNPs from <em>Hericium erinaceus</em> (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells
... Neurite outgrowth stimulation of AuNPs and aqueous extract of ...The neurite outgrowth stimulation in treated PC-12 cells was dose dependent (Figure ...of neurite-bearing cells of AuNPs ...
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Downstream of tyrosine kinase/docking protein 6, as a novel substrate of tropomyosin-related kinase C receptor, is involved in neurotrophin 3-mediated neurite outgrowth in mouse cortex neurons
... It has been reported that many adaptor proteins may bind to the NPQY motif in Trk receptor ICDs through the PTB domain, such as Shc, insulin receptor substrate (IRS) and fibroblast growth factor receptor substrate 2 ...
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Original Article rAAV-mediated delivery of brain-derived neurotrophic factor promotes neurite outgrowth and protects neurodegeneration in focal ischemic model
... Abstract: Stroke is one of the neurological diseases which lead to permanently neuronal damage after temporary or long-term occlusion of vessels or after heart attack. However, there are few efficient strategies to ...
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Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions.
... influence neurite outgrowth and cell survival of cerebellar granule ...stained. Neurite outgrowth was quantitated by measuring the ten longest neurites of ten aggregates in three independent ...
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A comparison of high-content screening versus manual analysis to assay the effects of mesenchymal stem cell-conditioned medium on neurite outgrowth in vitro.
... total neurite area coverage per DRG explant and in the total number of neurite branch points per DRG explant in MSC-CM compared to DRG explants in control medium ...entire neurite outgrowth ...
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Diabetes impairs an interleukin-1β-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons
... promote neurite outgrowth from DRG ...increased neurite outgrowth via p38 MAPK activation ...enhanced neurite outgrowth via direct effects on cultured ...
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Synergic interaction between amyloid precursor protein and neural cell adhesion molecule promotes neurite outgrowth
... that neurite outgrowth from various types of primary neurons was stimulated by homophilic NCAM ...that neurite outgrowth was promoted when hippocampal neurons and PC12E2 cells were co-cultured ...
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