neuroblastoma cell line
Original Article Sorafenib downregulates ERK/Akt and STAT3 survival pathways and induces apoptosis in a human neuroblastoma cell line
... Abstract: Neuroblastoma is a common solid tumor in children and its tumorigenicity is enhanced by the expression of survival pathways such as Akt and signal transducer and activator of transcription 3 ...human ...
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Autonomous growth of a human neuroblastoma cell line is mediated by insulin like growth factor II
... Insulin-like growth factor II (IGF-II) mRNA was increased in two of eight neuroblastomas and in eight of eight pheochromocytomas, tumors of the adrenal medulla that occur in childhood and adulthood, respectively. RNA ...
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On the cytotoxicity of HCR NTPase in the neuroblastoma cell line SH SY5Y
... Analysing the phylogenetic distribution of COG1618 pro- teins by phylogenetic COG ranking [11,12] reveals that they are absent from almost all mesophiles and present in all thermophiles, most of them archeae. In ...
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Viologen-phosphorus dendrimers exhibit minor toxicity against a murine neuroblastoma cell line
... the cell via clathrin-dependent endocytosis and/or macropinocytosis [50-53] and the process of dendrimer uptake has been shown to reach completion within 4 h ...the cell within the first hours after ...
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Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression
... human neuroblastoma cells were treated with sev- eral of these same compounds and subjected to Western analysis, marked degradation of tau was observed and in some cases a high molecular weight (HMW) tau species ...
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The NRSF and USF transcription factor families regulate pro-convulsant neuropeptides and are targets for anti-convulsant drug treatment: implications for epilepsy
... Epilepsy is a chronic neurological disorder which can arise following an initial insult that over time, progresses into a condition characterised by recurrent spontaneous seizures. During a latent period between the ...
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SH-SY5Y-derived neurons: A neuronal model system for investigating TAU sorting mechanisms and neuronal subtype-specific TAU vulnerability
... SH-SY5Y neuroblastoma cell line is widely used for studying TAU physiology and TAU-related pathology in Alzheimer’s disease (AD) and related ...neuronal cell polarity, high TAU protein levels, ...
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Identification of alpha,beta-Hydrolase Domain Containing Protein 6 as a Diacylglycerol Lipase in Neuro-2a Cells
... murine neuroblastoma cell line Neuro-2a and found that RA elevated cellular 2-AG levels in Neuro-2a cells during differentiation and recombinant expression of DAGLα or DAGL β increased neurite ...
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Effect of papaverine treatment on replication of measles virus in human neural and nonneural cells.
... Subsequently we examined the mechanisms for the inhibition of MV replication in the human neuroblastoma cell line in which the most marked suppression was observed and found that viral R[r] ...
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Fluorescence of Senna simea Lam leaf extracts: A possible interference in a fluorescence based assay
... human neuroblastoma cell line, LAN-5, was selected as our in vitro model for this current study since it has been demonstrated to express multiple neurotransmitter transporter expression [15, ...
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Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury
... ALS is an ultimately lethal disease with a high inter-sub- ject variation of progression. It is characterized by the degeneration of cortical and spinal motor neurons. ALS appears to be a multifactorial disease, where ...
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Infection of peripheral blood mononuclear cells and cell lines by cell free human T cell lymphoma/leukemia virus type I
... The two glioma cell lines bound high levels of the virus and were susceptible to infection by HTLV-I, while the neuroblastoma cell line, SK-N-MC, although binding high levels of the viru[r] ...
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Effects of the Mortalin Inhibitor MKT-077 on the Tumor Suppressor p53 in Neuroblastoma IMR-32 Cells
... cancer cell lines (Walker et al., 2006). In cell lines where the complex is present, mortalin inhibitors, such as the chemical agent MKT-077, have been effective in freeing p53 by competitively binding to ...
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Antiproliferative and apoptosis inducing potential of whole plant extracts of Sesuvium portulacastrum against different cancer cell lines
... human neuroblastoma cell line (IMR-32), and human colon cancer cells (HCT-116) using the 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT) ...different cell lines ...
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CRISPR Cas9 screen reveals a MYCN amplified neuroblastoma dependency on EZH2
... MYCN-nonamplified neuroblastoma cell lines than in MYCN-amplified neuroblastoma cell lines (Figure ...MYCN-amplified neuroblastoma cell line SK-N-BE(2) and performed a ...
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Over-expression of AhR (aryl hydrocarbon receptor) induces neural differentiation of Neuro2a cells: neurotoxicology study
... neurogenesis, neuroblastoma is widely used as an experimental model. Neuroblastoma usually arises from the proliferation of neural crest-derived precursors resulting in defective differentiation in vivo ...
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Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells
... the neuroblastoma cell line IMR32 ...1b). Cell cycle analysis revealed a significant increase in the number of cells at the G2/M phase ...
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Upregulation of CRABP1 in human neuroblastoma cells overproducing the Alzheimer-typical Aβ42reduces their differentiation potential
... the cell shape and number of cells were eval- ...the cell confluency and duration of RA treatment (cells were checked daily by light microscopy for up to 10 ...
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<p>Potent in vitro and xenograft antitumor activity of a novel agent, PV-10, against relapsed and refractory neuroblastoma</p>
... ing cell cycle changes and initiating cell death by ...representative cell lines and in vivo in immuno- compromised mice, provide evidence for the direct cytotoxic potential of PV-10, as well as ...
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A Nucleotide based Drug Protects Against Glutamate and MPP+ Induced Neurotoxicity
... pyrimidine nucleotides, on human neuroblastoma SH- SY5Y cell line and a primary culture of cortical neurons. Pyrimidine nucleotides have long been known as inter- mediates in cell metabolism ...
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