neuroblastoma cell lines
High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL- 2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition
... ABT263, neuroblastoma cell lines expressing high BCL-2 mRNA levels responded more potently to ABT199 than low BCL- 2-expressing cell lines, with an over 90-fold difference in average LC ...
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Successful Transmission of Three Mouse-Adapted Scrapie Strains to Murine Neuroblastoma Cell Lines Overexpressing Wild-Type Mouse Prion Protein
... Preparation of brain homogenates. Brains infected with Chandler strain were obtained from terminal stage CD-1 mice that had been inoculated with cell lysates of ScN2a (30), which were kindly donated by B. Caughey ...
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Identification of different ALK mutations in a pair of neuroblastoma cell lines established at diagnosis and relapse
... in neuroblastoma, designed in collaboration with the SIOPEN Biology Group:- NRAS, MDM4, MYCN, ALK, IDH1, PIK3CA, PDGFRA, TERT, FGFR4, CDK6, BRAF, FGFR1, MYC, CDKN2A, CDKN2B, PTCH1, TSC1, PTPRD, PTEN, HRAS, CCND1, ...
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IN VITRO CYTOTOXICITY EVALUATION OF ESCITALOPRAM LOADED NANOPARTICLES AFTER EXPOSURE TO NEUROBLASTOMA CELL LINES
... of cell morphology (microscopic and DAPI staining evaluation) and quantitative colorimetric assays like - neutral red (NRU), MTT and ...in cell count whereas; ETP NP’s showed lesser ...of cell ...
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Insights into Neuroblastoma Initiation and Disease Progression Through integrative Genomics and Epigenomics
... four neuroblastoma cell lines (SNP rs2168101: SHSY5Y = G/G; NLF = G/T; NGP = G/G; NB1643 = ...each cell line, indexed, pooled and sequenced using an Ion 318 Chip on a Personal Genome Machine ...
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Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma
... non-amplified cell lines was not statistically significant, in contrast to our previous study with Nutlin-3 and MI-63 [18] but consistent with another ...non-amplified neuroblastoma cell ...
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Estimating transfection efficiency in differentiated and undifferentiated neural cells
... or neuroblastoma cells (B35 and B104) were transiently transfected using Lipo- fectamine 2000 (Invitrogen) and pEGFP-N3 (Clenotech) fol- lowing a previously described protocol ...and neuroblastoma ...
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Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth
... Schwann cell marker S100 ...in neuroblastoma cell lines, along with SHEP and S16 cells used here as in vitro models of Schwannian stromal cells (5, 6, ...Schwann cell line S16 (Figure ...
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LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation
... of neuroblastoma cells to LIMK inhibitors, we tested 6 neuroblastoma cell lines for their responses to LIMKi (Figure ...6 cell lines were compared to CRT0105950 and CRT0105446 EC ...
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Expression of a Cu,Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of neuroblastoma cells to infectious injury
... human neuroblastoma cell lines constitu- tively expressing either wild-type (Wt) human SOD1 or the G93A mutant of this enzyme associated with familial amyotrophic lateral sclerosis (FALS) were ...
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Emerging treatment options for the treatment of neuroblastoma: potential role of perifosine
... high-risk neuroblastoma, the most common extracranial solid tumor in children, remains a formidable task despite the recent addition of antibody-mediated anti-GD2 immunotherapy to established multimodality ...
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Human oligodendroglial cells express low levels of C1 inhibitor and membrane cofactor protein mRNAs
... droglial cell line produces MCP, DAF, CD59, C1-inh and S-protein, but not complement receptor 1 (CR1) ...and neuroblastoma cell lines C1-inh [18]. Astrocytoma cell lines have ...
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Immunoassays for the quantification of ALK and phosphorylated ALK support the evaluation of on-target ALK inhibitors in neuroblastoma.
... two neuroblastoma cell lines to compare crizotinib and ceritinib treatment in a dose-dependent and time-dependent manner using the total ALK, pY ALK, pY1278, pY1604 and pY1586 ALK immunoassays ...
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Inhibition of CDK4/6 as a novel therapeutic option for neuroblastoma
... 131 cell cycle regula- tors in two neuroblastoma cell lines (NGP and IMR-32) followed by monitoring of neuroblastoma cell growth in real ...in cell cycle regulation at ...
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Aurora B kinase is a potent and selective target in MYCN-driven neuroblastoma
... of neuroblastoma cell lines with a preference for the MYCN-amplified and TP53 wild-type ...small cell lung cancer cell lines and MYC-overexpressing RPE cells [30, ...
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The ATRA-induced differentiation of medulloblastoma cells is enhanced with LOX/COX inhibitors: an analysis of gene expression
... treated cell populations was isolated using the GenElute™ Mammalian Total RNA Miniprep Kit (Sigma), and its concentration and integrity were determined using a ...each cell line and inhibitor ...
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DNMT1 regulates expression of MHC class I in post-mitotic neurons
... conditions [13, 14]. However, during several pathological conditions MHC-I expression can be induced in neurons where they are believed to play an active role in the disease process. This is the case for both autoimmune ...
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Nerve growth factor: role in growth, differentiation and controlling cancer cell development
... tumor cell in- duction and/or progression ...tumor cell lines from neuroblastoma, lymphoma, glioma, medulloblastoma adrenal tumors and melanoma, suggesting that NGF administration on trkA NGFR ...
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Attenuating mutations in the poliovirus 5' untranslated region alter its interaction with polypyrimidine tract-binding protein.
... in neuroblastoma cells but not in HeLa ...in neuroblastoma cells but not in HeLa ...and neuroblastoma cells, and cross-linked poorly to pPTB from both cell ...SH-SY5Y cell lines ...
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Enhancement of ATRA-induced differentiation of neuroblastoma cells with LOX/COX inhibitors: an expression profiling study
... blastoma cell lines ...SH-SY5Y cell line and in the expression of the CDKN1A gene after combined treatment with ATRA and both inhibitors; the CDKN1B gene was overex- pressed in SH-SY5Y cells with a ...
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